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This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage for 4 weeks. HgCl2-treated groups had significantly higher white blood cell and thrombocyte counts than the control group. Serum activities of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl-transferase, and lactate dehydrogenase significantly increased and serum levels of total protein, albumin, triglyceride, total cholesterol, and low-density lipoprotein cholesterol significantly decreased in the HgCl2-treated groups compared with control group. Malondialdehyde level significantly increased and superoxide dismutase, catalase, and glutathione peroxidase activities decreased in liver tissue of HgCl2-treated rats. Also, HgCl2 exposure resulted in histopathological changes. Supplementation of Na2SeO3 and/or vitamin E provided partial protection in hematological and biochemical parameters that were altered by HgCl2 As a result, Na2SeO3 and/or vitamin E significantly reduced HgCl2-induced hepatotoxicity, but not protected completely.

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Bisphenol A (BPA) has endocrine-disrupting properties. The present study aimed to examine the possible protective roles of curcumin and taurine against BPA-induced small intestine toxicity in rats. For this purpose, forty-two adult albino male rats were divided seven equal groups: control, olive oil, curcumin (100 mg kg -1 daily), taurine (100 mg kg -1 daily), BPA (130 mg kg -1 daily), curcumin+BPA, taurine+BPA. After four weeks on treatment small intestine tissues were examined for histopathological examinations. BPA caused seriously toxicity on small intestine tissues, but curcumin and taurine did not have completely protective effects of this damage.