Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E

Kalender, Suna; Uzun, Fatma; Demir, Filiz; Uzunhisarcıklı, Meltem; Aslantürk, Ayşe

doi:10.1016/j.fct.2013.01.024

Cited by 85 publications

(72 citation statements)

References 63 publications

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“…The endogenous antioxidant enzymes such as SOD, CAT, GPx and GST present the first line of cellular antioxidative defense against free-radical damage (Hassani et al 2015). Inhibition in the activities of antioxidant enzymes like SOD, CAT, GPx and GST in various rat tissues mercuric chloride-treated was revealed in previously studies (Gado and Aldahmash 2103;Kalender et al 2013). Results showed that there was a statistically significant decrease in SOD, CAT, GPx and GST activities in the lung tissues of mercury chloride treated rats.…”

Section: Discussionmentioning

confidence: 86%

“…Previous studies have shown that heavy metals induced elevated MDA level in the lung tissue (Sener et al 2003;Sener et al 2007;Karaca and Eraslan 2013). Enhanced level of lipid peroxidation was also reported in mercuric chloride toxicity (Kalender et al 2013;Aslanturk et al 2014;Othman et al 2014;Agha et al 2014). The escalation of lung MDA level may be due to the adverse effect of mercuric chloride on cell membrane.…”

Section: Discussionmentioning

confidence: 90%

“…Selenium has the ability to reduce the toxicity of several xenobiotics, including heavy metals (Agha et al 2014). Many studies have reported that, when selenium in the form of sodium selenite is given in combination with mercury administration, it significantly alleviates the mercury-induced toxic effects (Kalender et al 2013;Agha et al 2014). Selenium possesses an affinity for mercury higher than that of sulfhydryl compounds and the protection offered by sodium selenite in mercury intoxication has been based on to the formation of Hg-Se-S complex to form a non-toxic complex (Perottoni et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Mercuric chloride is one of the most toxic forms of mercury and is primarily nephrotoxic (MoraesSilva 2014). It is well known as hematotoxic (Durak et al 2010), hepatotoxic (Joshi et al 2014;Othman et al 2014), neurotoxic (Moraes-Silva et al 2014), nephrotoxic (Aslanturk et al 2014) and genotoxic (Rozgaj et al 2005) and exerts negative effects on the reproductive system in male rat (Kalender et al 2013). …”

Section: Introductionmentioning

confidence: 99%

“…It protects the body's biological systems due to preventions of lipid peroxidation by scavenging free radicals ability in lipoprotein membranes (Al Attar 2011). Several studies have reported that vitamin E and selenium play beneficial role against adverse effects of toxic compounds in various organ (Kalender et al 2013;Dezfouli et al 2014;Ranjan et al 2014;Hassani et al 2015). However, vitamin E and selenium are not only effective against oxidative damage alone, but also have a synergistic effect when they are used together (Schwenke and Behr 1998).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Çelikoğlu

Aslantürk

Kalender

2015

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Çelikoğlu

Aslantürk

Kalender

2015

Braz. arch. biol. technol.

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Diphenyl diselenide protects against methylmercury‐induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen

Meinerz

Branco

Aschner

et al. 2017

J of Applied Toxicology

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Exposure to methylmercury (MeHg), an important environmental toxicant, may lead to serious health risks, damaging various organs and predominantly affecting the brain function. The toxicity of MeHg can be related to the inhibition of important selenoenzymes, such as glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). Experimental studies have shown that selenocompounds play an important role as cellular detoxifiers and protective agents against the harmful effects of mercury. The present study investigated the mechanisms by which diphenyl diselenide [(PhSe) ] and ebselen interfered with the interaction of mercury (MeHg) and selenoenzymes (TrxR and GPx) in an in vitro experimental model of cultured human neuroblastoma cells (SH-SY5Y). Our results established that (PhSe) and ebselen increased the activity and expression of TrxR. In contrast, MeHg inhibited TrxR activity even at low doses (0.5 μm). Coexposure to selenocompounds and MeHg showed a protective effect of (PhSe) on both the activity and expression of TrxR. When selenoenzyme GPx was evaluated, selenocompounds did not alter its activity or expression significantly, whereas MeHg inhibited the activity of GPx (from 1 μm). Among the selenocompounds only (PhSe) significantly protected against the effects of MeHg on GPx activity. Taken together, these results indicate a potential use for ebselen and (PhSe) against MeHg toxicity. Furthermore, for the first time, we have demonstrated that (PhSe) caused a more pronounced upregulation of TrxR than ebselen in neuroblastoma cells, likely reflecting an important molecular mechanism involved in the antioxidant properties of this compound. Copyright © 2017 John Wiley & Sons, Ltd.

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The human health risks assessment of mercury in soils and plantains from farms in selected artisanal and small‐scale gold mining communities around Obuasi, Ghana

Addai-Arhin

Novirsa

Jeong

et al. 2021

J of Applied Toxicology

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Food consumption remains the commonest pathway through which humans ingest higher levels of mercury (Hg). Long-term exposure to Hg through Hg-contaminated food may result in acute or chronic Hg toxicity. Incessant discharge of Hg waste from ASGM facilities into nearby farms contaminates food crops. Ingestion of such food crops by residents may lead to detrimental human health effects. The human health risks upon exposure to total mercury (THg) and methylmercury (MeHg) in farmland soils and plantains from farms sited near ASGM facilities were studied in four communities around Obuasi, Ghana. The human health risk assessment was evaluated using hazard quotient (HQ), estimated average daily intake ( e AvDI), hazard index (HI) and Hg elimination and retention kinetics. Tweapease, Nyamebekyere and Ahansonyewodea had HQ, e AvDI and HI for THg of plantains for both adults and children below the recommended USEPA limit of 1, 3 Â 10 À4 mg/kg/day and 1, respectively. Odumase had HQ, e AvDI and HI for THg of plantains for both adults and children, higher than the guideline values. This meant that only Odumase may cause non-carcinogenic human health effects upon repeated exposure. The HQ, e AvDI and HI values of MeHg for all the study areas were far below guideline values, hence may not pose any non-carcinogenic human health risks to residents even upon repeated exposure. Retention and elimination kinetics of Hg also showed that only plantains from Odumase may pose significant non-carcinogenic human health risks to residents because the final amount of inorganic mercury exceeded the extrapolated USEPA guideline value of 0.393 μg/kg/year.

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Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E

Cited by 85 publications

References 63 publications

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Diphenyl diselenide protects against methylmercury‐induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen

The human health risks assessment of mercury in soils and plantains from farms in selected artisanal and small‐scale gold mining communities around Obuasi, Ghana

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