2003
DOI: 10.1016/s0278-2626(02)00530-4
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Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations

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Cited by 31 publications
(23 citation statements)
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“…On one hand, it is the severity of dopaminergic neurotransmission by the antagonistic effect of caffeine on the A 1 and A 2A receptors, on the other hand, the inhibition of neuronal DA reuptake by bupropion that potentiates the DA signaling in the CNS. At the same time, both substances also increase noradrenergic neurotransmission[47,60]. Kale and Addepalli[32] in their research on mice, where bupropion and caffeine at doses of 5 mg/kg each have been co-administered, also observed a statistically significant reduction in the immobility time of animals in the FST and in the tail suspension test.…”
mentioning
confidence: 94%
“…On one hand, it is the severity of dopaminergic neurotransmission by the antagonistic effect of caffeine on the A 1 and A 2A receptors, on the other hand, the inhibition of neuronal DA reuptake by bupropion that potentiates the DA signaling in the CNS. At the same time, both substances also increase noradrenergic neurotransmission[47,60]. Kale and Addepalli[32] in their research on mice, where bupropion and caffeine at doses of 5 mg/kg each have been co-administered, also observed a statistically significant reduction in the immobility time of animals in the FST and in the tail suspension test.…”
mentioning
confidence: 94%
“…The stimulant effects of caffeine are not due to direct actions on the central nervous system, but to indirect stimulation by inducing blockade of another neuromodulator, adenosine, which usually exerts a calming effect on brain and spinal cord neurons 22 . Caffeine increases the amount of adrenaline and noradrenaline secreted by the adrenal medulla 23 and increases central noradrenaline synthesis and turnover in the cerebral cortex, consequently exerting a stimulatory effect and boosting wakefulness 24 . In a U.S. study, 41% of school-aged children were found to consume at least one caffeinated beverage per day.…”
Section: Discussionmentioning
confidence: 99%
“…Caffeine is known to cause elevations in blood pressure (James & Gregg, 2004) and elevations in catecholamines (Papadelis et al, 2003), which could result in elevated blood pressure and HR. Since guaraná extract is always delivered in combination with caffeine, it is difficult to ascertain the unique contributions of guaraná to these physiological outcomes.…”
Section: Guaranámentioning
confidence: 99%