Effects of mechanical injury on the tribological rehydration and lubrication of articular cartilage

Farnham, Margot S.; Larson, Riley E.; Burris, David L.; Price, Christopher

doi:10.1016/j.jmbbm.2019.103422

Cited by 16 publications

(10 citation statements)

References 41 publications

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“…However, we received the impression that there is a lack of data in the literature regarding tribological examinations of regenerated AC tissue that was tribologically tested with AC as a counterpart. AC and regenerated AC were mostly tested against alloplastic materials such as glass [ 8 , 10 , 11 , 13 ]. By testing AC against AC, we hoped to get more specific CoF values, as the CoF curves in such examinations revealed a constant and lower CoF over an observation time of 1 h [ 4 , 37 ], 8 h [ 17 ], or even 15 h [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Many papers have been published, and several different tribological testing procedures and devices have been described where pin-on-plate apparatuses were frequently used [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, where pin-on-plate setups are concerned, fewer scientific reports dealing with cartilage on cartilage systems have been published than those dealing with cartilage against alloplastic materials, mainly glass [ 8 , 10 , 11 , 13 ]. We believe that there is a lack of data in the literature that focuses on the evaluation of the CoF when AC and regenerated AC are tribologically examined against cartilage.…”

Section: Introductionmentioning

confidence: 99%

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Coefficient of Friction and Height Loss: Two Criteria Used to Determine the Mechanical Property and Stability of Regenerated Versus Natural Articular Cartilage

et al. 2022

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Background: The coefficient of friction (CoF) serves as an indicator for the mechanical properties of natural and regenerated articular cartilage (AC). After tribological exposure, a height loss (HL) of the cartilage pair specimens can be measured. Our aim was to determine the CoF and HL of regenerated AC tissue and compare them with those of natural AC from non-operated joints and AC from joints where the regenerated tissues had been created after different treatments. Methods: In partial-thickness defects of the trochleae of the stifle joints of 60 Göttingen Minipigs, regenerated AC was created. In total, 40 animals received a Col I matrix, 20 laden with autologous chondrocytes, and 20 without. The defects of 20 animals were left empty. The healing periods were 24 and 48 weeks. A total of 10 not-operated animals, delivered the “external” control specimens. Osteochondral pins were harvested from defect and non-defect areas, the latter serving as “internal” controls. Using a pin-on-plate tribometer, we measured the CoF and the HL. Results: The CoF of the regenerated AC ranged from 0.0393 to 0.0688, and the HL, from 0.22 mm to 0.3 mm. The differences between the regenerated AC of the six groups and the “external” controls were significant. The comparison with the “internal” controls revealed four significant differences for the CoF and one for the HL in the operated groups. No differences were seen within the operated groups. Conclusions: The mechanical quality of the regenerated AC tissue showed inferior behavior with regard to the CoF and HL in comparison with natural AC. The comparison of regenerated AC tissue with AC from untreated joints was more promising than with AC from the treated joints.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Coefficient of Friction and Height Loss: Two Criteria Used to Determine the Mechanical Property and Stability of Regenerated Versus Natural Articular Cartilage

et al. 2022

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“…While fluid lubrication has been highlighted as a critical element of CoF variations in experimental studies [ 58 , 81 ], boundary lubrication shows a remarkable improvement since cartilage is biphasic and retains fluid in its superficial layer [ 82 ]. By lubricant depletion, the CoF is mostly altered as a function of surface chemistry [ 56 ].…”

Section: Tribological Properties Of Articular Cartilagementioning

confidence: 99%

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

2021

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The design and manufacture of artificial tissue for knee joints have been highlighted recently among researchers which necessitates an apt approach for its assessment. Even though most re-searches have focused on specific mechanical or tribological tests, other aspects have remained underexplored. In this review, elemental keys for design and testing artificial cartilage are dis-cussed and advanced methods addressed. Articular cartilage structure, its compositions in load-bearing and tribological properties of hydrogels, mechanical properties, test approaches and wear mechanisms are discussed. Bilayer hydrogels as a niche in tissue artificialization are presented, and recent gaps are assessed.

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“…Blunt trauma and its repetition over a period of time can cause changes in the cartilage matrix, including a reduction in the matrix proteoglycan and collagen disruptions [56,57]. In these cases, if the complication is not severe and chronic, the matrix is regenerated by chondrocytes [58,59].…”

Section: Articular Cartilage Injury and Response Of Damaged Tissuementioning

confidence: 99%

An overview of various treatment strategies, especially tissue engineering for damaged articular cartilage

Bakhshayesh

Babaie

Nasrabadi

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Many traditional procedures, including surgical methods such as microfracture of subchondral bone and soft tissue transplantation, have been widely used to treat damaged cartilage. However, there is still no definitive cure for cartilage defects. In recent decades, tissue engineering has raised hopes for the repair of defective cartilage. Different approaches are used for cartilage engineering, in which cells, scaffolds, and biological signals or growth factors may be used alone or in combination. Additionally, the imitation of the mechanical properties of the natural cartilage tissue by bioreactors is also helpful in this regard. It should be noted that in the transplantation of engineered cartilage tissue, there are challenges such as poor integration, inflammation and phenotypic instability that may lead to failure of neo-cartilage transplantation. Therefore, a comprehensive understanding of the multiple therapeutic approaches, including surgical procedures, cell-based methods and tissue engineering, should be obtained. The present review article provides this information, along with a variety of factors, including cells, materials, and biological/biomechanical factors required for the engineering of cartilage tissue, as well as the challenges ahead and their solutions.

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Effects of mechanical injury on the tribological rehydration and lubrication of articular cartilage

Cited by 16 publications

References 41 publications

Coefficient of Friction and Height Loss: Two Criteria Used to Determine the Mechanical Property and Stability of Regenerated Versus Natural Articular Cartilage

Coefficient of Friction and Height Loss: Two Criteria Used to Determine the Mechanical Property and Stability of Regenerated Versus Natural Articular Cartilage

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

An overview of various treatment strategies, especially tissue engineering for damaged articular cartilage

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