Effects of maternal undernutrition during lactation on estrogen and androgen receptor expressions in rat ovary at puberty

Faria, T.; Brasil, Flávia de Bittencourt; Sampaio, Francisco J.B.; Ramos, Cristiane da Fonte

doi:10.1016/j.nut.2009.09.027

Cited by 32 publications

(18 citation statements)

References 38 publications

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“…Thus, prenatal undernutrition appears to disturb ovarian function, and may be a contributing factor in the delay of VO in IUGR pups. Additionally, postnatal nutrition (i.e., maternal protein-and energy-restricted diets during lactation) has been shown to also reduce the number of primordial follicles, Graafian follicles and the corpus luteum, as well as the number of ovarian estrogen and androgen receptors in rat offspring [40]. Furthermore,…”

Section: Discussionmentioning

confidence: 99%

Delay in the onset of puberty of intrauterine growth retarded female rats cannot be rescued with hypernutrition after birth

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Delay in the onset of puberty of intrauterine growth retarded female rats cannot be rescued with hypernutrition after birth

et al. 2012

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“…In mammals, primordial follicles begin to form before or during the first few days after birth ( Faria et al, 2010 ). Then the primordial follicles transit into primary follicles and initiate folliculogenesis ( Faria et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Maternal Low-protein Diet Alters Ovarian Expression of Folliculogenic and Steroidogenic Genes and Their Regulatory MicroRNAs in Neonatal Piglets

Sui

Jia

et al. 2014

Asian Australas. J. Anim. Sci

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Maternal malnutrition during pregnancy may give rise to female offspring with disrupted ovary functions in adult age. Neonatal ovary development predisposes adult ovary function, yet the effect of maternal nutrition on the neonatal ovary has not been described. Therefore, here we show the impact of maternal protein restriction on the expression of folliculogenic and steroidogenic genes, their regulatory microRNAs and promoter DNA methylation in the ovary of neonatal piglets. Sows were fed either standard-protein (SP, 15% crude protein) or low-protein (LP, 7.5% crude protein) diets throughout gestation. Female piglets born to LP sows showed significantly decreased ovary weight relative to body weight (p<0.05) at birth, which was accompanied with an increased serum estradiol level (p<0.05). The LP piglets demonstrated higher ratio of bcl-2 associated X protein/B cell lymphoma/leukemia-2 mRNA (p<0.01), which was associated with up-regulated mRNA expression of bone morphogenic protein 4 (BMP4) (p<0.05) and proliferating cell nuclear antigen (PCNA) (p<0.05). The steroidogenic gene, cytochrome P450 aromatase (CYP19A1) was significantly down-regulated (p<0.05) in LP piglets. The alterations in ovarian gene expression were associated with a significant down-regulation of follicle-stimulating hormone receptor mRNA expression (p<0.05) in LP piglets. Moreover, three microRNAs, including miR-423-5p targeting both CYP19A1 and PCNA, miR-378 targeting CYP19A1 and miR-210 targeting BMP4, were significantly down-regulated (p<0.05) in the ovary of LP piglets. These results suggest that microRNAs are involved in mediating the effect of maternal protein restriction on ovarian function through regulating the expression of folliculogenic and steroidogenic genes in newborn piglets.

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“…Calorie restriction (50%) in Wistar rats during pregnancy and lactation, but not either period alone, resulted in a significant 50% lower primordial follicle density in 150-day-old offspring (Bernal et al 2010). Conversely, in a separate study, protein restriction during lactation only in Wistar rats resulted in a significant 60% lower primordial follicle density at puberty in 40-day-old offspring (da Silva Faria et al 2010a), whilst only a 21% lower density was reported by the same authors in 90-day adult offspring (da Silva Faria et al 2010b).…”

Section: Introductionmentioning

confidence: 81%

“…restriction and technical differences in the methods used to analyse follicles. Unlike previous reports of maternal protein restriction on offspring ovarian reserve, which measured follicle density (Bernal et al 2010, da Silva Faria et al 2010a,b, Guzman et al 2014, we have estimated total follicle numbers as previously detailed (Tilly 2003). We recently reported that follicle density values do not correspond with total follicle estimates calculated in the same mouse ovary (Winship et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Oocytes are formed during in utero development and then assembled into primordial follicles before birth, or shortly after, depending on the species (reviewed Findlay et al 2015). Consequently, exposure to a suboptimal environment during foetal and early postnatal development, such as maternal undernutrition, has been shown to impair offspring ovarian reserve programming in animal models (Bernal et al 2010, da Silva Faria et al 2010a,b, Guzman et al 2014. Some evidence suggests that exposure to malnutrition during maternal oocyte maturation prior to pregnancy can also impact offspring phenotypes.…”

Section: Introductionmentioning

confidence: 99%

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Maternal low protein diet programmes low ovarian reserve in offspring

et al. 2018

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The ovarian reserve of primordial follicle oocytes is formed during in utero development and represents the entire supply of oocytes available to sustain female fertility. Maternal undernutrition during pregnancy and lactation diminishes offspring ovarian reserve in rats. In mice, maternal oocyte maturation is also susceptible to undernutrition, causing impaired offspring cardiovascular function. We aimed to determine whether programming of the ovarian reserve is impacted in offspring when maternal undernutrition extends from preconception oocyte development through to weaning. C57BL6/J female mice were fed normal protein (20%) or low protein (8%) diet during preconception, pregnancy and lactation periods. Maternal ovaries were harvested at weaning and offspring ovaries collected at postnatal day (PN)21 and 24 weeks of age. Total follicle estimates were obtained by histologically sampling one ovary per animal (n=5/group). There was no impact of diet on maternal follicle numbers. However, in offspring, maternal protein restriction significantly depleted primordial follicles by 37% at PN21 and 51% at 24 weeks (p<0.05). There were no effects of diet on other follicle classes. Histological analysis showed no differences in the proportion of proliferative follicles (pH3-positive), but increased atresia (cleaved caspase-3-positive, or TUNEL-positive) was detected in ovaries of protein-restricted offspring at both ages (p<0.05). Our data show that maternal diet during the preconception period, in utero development and early life has significant impacts on follicle endowment and markers of follicle health later in life. This highlights the need for further investigation into the importance of maternal preconception diet for offspring reproductive development and health.

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Effects of maternal undernutrition during lactation on estrogen and androgen receptor expressions in rat ovary at puberty

Abstract: Our results suggest that maternal protein- and energy-restricted diets during lactation can disturb the follicular development of the offspring, probably by reducing the number of androgen and estrogen receptors in the ovary.

Cited by 32 publications

References 38 publications

Delay in the onset of puberty of intrauterine growth retarded female rats cannot be rescued with hypernutrition after birth

Delay in the onset of puberty of intrauterine growth retarded female rats cannot be rescued with hypernutrition after birth

Maternal Low-protein Diet Alters Ovarian Expression of Folliculogenic and Steroidogenic Genes and Their Regulatory MicroRNAs in Neonatal Piglets

Maternal low protein diet programmes low ovarian reserve in offspring

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