Delay in the onset of puberty of intrauterine growth retarded female rats cannot be rescued with hypernutrition after birth

Gereltsetseg, Ganbat; Matsuzaki, Takashi; Iwasa, Takeshi; Kinouchi, Riyo; Nakazawa, Hiroshi; Yamamoto, Shozo; Kuwahara, Akira; Irahara, Minoru

doi:10.1507/endocrj.ej11-0392

Cited by 14 publications

(6 citation statements)

References 55 publications

(42 reference statements)

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“…The authors have reported that the onset of puberty and vaginal opening of female rats were delayed by prenatal undernutrition in rats . In the present study, PS, which is a reliable finding of puberty, was significantly delayed in the mUN group, compared to the mNN group.…”

Section: Discussionsupporting

confidence: 48%

“…Prenatal undernutrition-induced pathogenesis of diseases, including hypertension, cardiovascular diseases, insulin resistance, and type 2 diabetes, in adulthood has been named as the origin of health and disease or metabolic programming. 2,3 It also has been reported that prenatal undernutrition has impaired the onset of puberty and the estrous cycle in male and female rats [4][5][6] and has induced metabolic disorders. 7,8 Furthermore, the exposure to lipopolysaccharide (LPS) in the early neonatal period has delayed vaginal opening and preputial separation (PS) and disrupted sexual behavior in male and female rats.…”

Section: Introductionmentioning

confidence: 99%

“…It also has been reported that prenatal undernutrition has impaired the onset of puberty and the estrous cycle in male and female rats and has induced metabolic disorders . Furthermore, the exposure to lipopolysaccharide (LPS) in the early neonatal period has delayed vaginal opening and preputial separation (PS) and disrupted sexual behavior in male and female rats .…”

Section: Introductionmentioning

confidence: 99%

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Prenatal undernutrition disrupted the sexual maturation, but not the sexual behavior, in male rats

Matsuzaki

Munkhzaya

Tungalagsuvd

et al. 2017

Reprod Medicine & Biology

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PurposeExposure to various stressors, including psychological, metabolic, and immune, in the perinatal period induces long‐lasting effects in physiological function and increase the risk of metabolic disorders in later life. In the present study, sexual maturation and sexual behavior were assessed in prenatally undernourished mature male rats.MethodsAll the pregnant rats were divided into the maternal normal nutrition (mNN) group and the maternal undernutrition (mUN) group. The mUN mothers received 50% of the amount of the daily food intake of the mNN mothers. Preputial separation and sexual behavior were observed in randomly selected pups of the mNN and mUN groups.ResultsThe body weight of the mothers was significantly lighter in the mUN group than in the mNN group. Similarly, the pups in the mUN group showed a significantly lower body weight than those in the mNN group from postnatal day (PND) 1 to PND 15. The preputial separation day was significantly delayed in the mUN group, compared to the mNN group. Sexual behavior did not show any significant difference between the two groups.ConclusionThese findings indicated that prenatal undernutrition delayed sexual maturation, but did not suppress sexual behavior, in mature male rats.

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Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prenatal undernutrition disrupted the sexual maturation, but not the sexual behavior, in male rats

Matsuzaki

Munkhzaya

Tungalagsuvd

et al. 2017

Reprod Medicine & Biology

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“…The brain integrates information about changes in the blood levels of energy substrates such as glucose, fatty acids, and ketone bodies through specific sensory systems (Shuichi and Koji, 2015). In addition, our previous studies demonstrated that FGR rats undergo rapid catch‐up growth in the developmental period, which can result in the delayed onset of puberty and lower hypothalamic kisspeptin mRNA expression levels due to accelerated leptin resistance in the prepubertal period (Iwasa et al, 2010; Gereltsetseg et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

The expression of orexigenic and anorexigenic factors in middle‐aged female rats that had been subjected to prenatal undernutrition

Tungalagsuvd

Matsuzaki

Iwasa

et al. 2015

Intl J of Devlp Neuroscience

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Fetal growth retardation, which affects short- and long-term fetal brain development, is associated with metabolic, hematological, and thermal disturbances, which can increase the risk of metabolic syndrome later in life. Orexigenic and anorexigenic factors regulate food intake and energy expenditure. We studied how the expression of these factors was affected by food deprivation (FD) in middle-aged female rats that had been subjected to prenatal undernutrition. Eight pregnant rats were divided into two groups, the normal nutrition (NN) (n=4) group and the undernutrition (UN) (n=4) group, which received 50% (approximately 11 g) of the daily food intake of the normal nutrition rats from day 13 of pregnancy to delivery. The pups from these dams were defined as the maternal NN (mNN) and maternal UN (mUN) groups, respectively. After weaning, all of the pups were housed and allowed ad libitum access to food and water. At the age of 6 months, both groups of pups were sub-divided into three groups. One group was allowed to consume normal amounts of food (Fed), and the other two groups were subjected to 24h or 48 h FD (n=7-8 per group). The rats' serum leptin levels and hypothalamic mRNA expression levels of various orexigenic or anorexigenic factors were measured. In both the mNN and mUN rats, the serum leptin levels of the 24h and 48 h FD groups tended to be lower than those of the Fed group, and the serum leptin levels of the 24h FD mUN rats and the Fed mUN rats differed significantly. The hypothalamic neuropeptide Y (NPY) mRNA expression levels of the 24h and 48 h FD groups were significantly higher in the mUN rats than in the mNN rats. In addition, among the mUN rats the hypothalamic NPY mRNA expression levels of the 48 h FD group were significantly higher than those of the Fed group. In both the mNN and mUN rats, prepro-orexin mRNA expression was lower in the 48 h FD group than in the corresponding Fed group. Among the mUN rats, the 48 h FD group exhibited significantly lower hypothalamic proopiomelanocortin (POMC) mRNA expression than the Fed group, and a similar tendency was seen among the mNN rats. Among the mNN rats, the 24h FD group displayed significantly higher hypothalamic leptin receptor (OBRb) mRNA levels than the Fed group. However, no such differences were seen among the mUN rats. As a result, the hypothalamic OBRb mRNA expression levels of the mUN rats in the 24h and 48 h FD groups were lower than those of the corresponding mNN rat groups. These findings indicate that rats that are subjected to prenatal undernutrition exhibit upregulated expression of orexigenic factors and are more sensitive to FD in middle age, which might increase their risk of developing metabolic disorders in later life.

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“…Studies addressing the impact of early postnatal overfeeding are scarce and report divergent observations depending on the species or strain as well as fat content of the diet. Using small litters (3-5 pups) in order to cause overnutri-tion, some authors did not observe any effect on pubertal onset in females (Gereltsetseg et al, 2012; while others have reported earlier puberty (Castellano et al, 2011;Smith and Spencer, 2012). In this case, earlier puberty is accompanied by an increase in serum leptin levels as well as increased expression of kiss1 mRNA expression in the whole hypothalamus.…”

Section: Peripubertal Food Restrictionmentioning

confidence: 97%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

157

140

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Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

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Delay in the onset of puberty of intrauterine growth retarded female rats cannot be rescued with hypernutrition after birth

Cited by 14 publications

References 55 publications

Prenatal undernutrition disrupted the sexual maturation, but not the sexual behavior, in male rats

Prenatal undernutrition disrupted the sexual maturation, but not the sexual behavior, in male rats

The expression of orexigenic and anorexigenic factors in middle‐aged female rats that had been subjected to prenatal undernutrition

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

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