Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent, Anne-Simone; Franssen, Delphine; Fudvoye, Julie; Gérard, Arlette; Bourguignon, Jean-Pierre

doi:10.1016/j.yfrne.2014.12.004

Cited by 153 publications

(143 citation statements)

References 244 publications

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“…Animal studies indicate a plausible link between EDC and the timing of pubertal maturation, but epidemiologic evidence is scant and/or conflicting, as recently reviewed elsewhere (73). Polychlorinated biphenyls (PCBs) are found in fish from contaminated waters.…”

Section: Toxicants Present In Foodsmentioning

confidence: 99%

Nutritional Determinants of the Timing of Puberty

Villamor

Jansen

2016

Annu. Rev. Public Health

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The timing of puberty has important public health, clinical, and social implications. The plasticity of sexual development onset could be a mechanism that adapts to prevailing environmental conditions. Early-life nutrition may provide cues for the environment's suitability for reproduction. This review focuses on recent developments in our understanding of the role of diet in the timing of sexual maturation. Population-based observational studies consistently indicate that childhood obesity is related to the earlier onset of puberty in girls. Similarly, intake of animal foods has been associated with earlier sexual development, whereas vegetable protein intake is related to delayed maturation. Evidence for prenatal nutrition, infant feeding practices, and childhood intake of fat, carbohydrate, and micronutrients is inconsistent. Secondary analyses of prenatal and early-life randomized nutritional interventions with extended follow-up through peripubertal years would help clarify the role of nutrition in the timing of sexual maturation.

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Section: Toxicants Present In Foodsmentioning

confidence: 99%

Nutritional Determinants of the Timing of Puberty

Villamor

Jansen

2016

Annu. Rev. Public Health

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“…En los seres humanos pueden tener efectos como pubertad temprana, cáncer de seno, de próstata, entre otras anomalías genéticas (Parent et al 2015, Castro y Fontoura 2015, Burks et al 2016, por lo que están siendo considerados para regulación.…”

Section: Presencia Y Concentración De Grupos Seleccionados (I IV De)unclassified

Estudio Exploratorio De La Presencia De Microcontaminantes en El Ciclo Urbano Del Agua en Colombia: Caso De Estudio Santiago De Cali

Madera-Parra

Jiménez-Bambague

Toro-Vélez³

et al. 2018

Rev. Int. Contam. Ambie.

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Palabras clave: compuestos farmacéuticos, disruptores endocrinos, agua potable, agua residual, agua superficial RESUMEN Los microcontaminantes incluyen una amplia gama de compuestos presentes en el ambiente en concentraciones de µg/L o ng/L. En este estudio se analizó la presencia y concentración de microcontaminantes como compuestos farmacéuticos y disruptores endocrinos en el ciclo urbano del agua de la ciudad de Santiago de Cali, Colombia, donde se incluyeron cuatro puntos de monitoreo de agua superficial, tres de agua potable y uno de agua residual. Se realizaron cinco jornadas de muestreo: un muestreo preliminar en el cual se cuantificaron 92 compuestos clasificados en cinco grupos de compuestos farmacéuticos (I, II, III, IV y V) y un grupo de disruptores endocrinos (DE), a partir del cual se priorizaron tres grupos a ser determinados en los cuatro muestreos siguientes. Los criterios de presencia, concentración, efectos sobre la biota acuática y financiamiento de la investigación, se emplearon para seleccionar los grupos I, IV y DE, los cuales tuvieron una presencia superior al 48 % y una concentración media de hasta 11 000 ng/L. Se encontró que los compuestos más relevantes, en términos de presencia y concentración en el ciclo urbano del agua fueron 10,11-dihydro-10,11-dihidroxicarbamazepina, ibuprofeno, naproxeno, gemfibrozilo, paracetamol, sulfametoxazol, estronas, 4-iso-nonilfenol y bisfenol A. La presencia en el ciclo urbano del agua de Cali genera una alerta por la potencial amenaza sobre los organismos acuáticos y la salud humana.Key words: pharmaceutical compounds, endocrine disruptors, drinking water, wastewater, superficial water ABSTRACT Micropollutants includes a wide variety of compounds in environmental concentrations of µg/L or ng/L. The presence and concentration of micropollutants, as pharmaceutical and endocrine disruptors compounds, were studied throughout the urban water cycle of Santiago de Cali city, Colombia. In order to do this, samples were collected in four points of surface water, three of drinking water and one of wastewater. Five samplings were carried out: one screening with 92 compounds measured, classified in five pharmaceutical compounds groups (I, II, III, IV and V) and one endocrine disruptors group Rev. Int.

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“…As mentioned earlier, the hypothalamic-pituitary gonadal axis is functional during fetal/perinatal period, leading to the sexualization of external genitalia and specific regions of the nervous system. This activation is limited in time but offers a window of sensitivity to external factors such as endocrine disruptors (Parent et al, 2015;Hines et al, 2016).…”

Section: Puberty: Endocrine or Brain Revolution?mentioning

confidence: 99%

“…In contrast, the poly-syalilated form of NCAM, PSA-NCAM, prevents hemophilic interactions between adjacent glial and GnRH neuronal cells. Heterophilic interactions also exist via the neuronal membrane protein contactin and the glial receptor like protein tyrosine phosphatase-b (Parent et al, 2007). These cellto-cell interactions can trigger intracellular signaling cascades that can affect both glial and neuronal activities (Viguie et al, 2001;Parkash and Kaur, 2007;Sharif et al, 2013).…”

Section: Glial Regulationmentioning

confidence: 99%

The timing of puberty (oocyte quality and management)

Duittoz¹,

Tillet²,

Bourhis³

et al. 2016

Anim Reprod

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This review aims at giving an overview on the physiological events leading to puberty onset in mammals and more specifically in cattle. Puberty is an important developmental milestone in mammals involving numerous changes in various physiological regulations and behaviors. It is a physiological unique event integrating several important central regulations at the crossroad of adaptation to environment: reproductive axis, feeding behavior and nutritional controls, growth, seasonal rhythm and stress. Puberty onset is also an important economic parameter in replacement heifer program and in genomic selection (genomic bulls). The quest for advanced puberty onset should be carefully balanced by its impact on physiological parameters of the animal and its offspring. Thus one has to carefully consider each step leading to puberty onset and set up a strategy that will lead to early puberty without being detrimental in the long term. In this review, major contributions in the understanding of puberty process obtained in rodents, primates and farm animals such as sheep and cattle are discussed. In the first part we will detail the endocrine events leading to puberty onset with a special focus on the regulation of GnRH secretion. In the second part we will describe the neural mechanisms involved in silencing and reactivating the GnRH neuronal network. These central mechanisms are at the crossroad of the integration of environmental factors such as the nutritional status, the stress and the photoperiod that will be discussed in the third part. In the fourth part, we will discuss the genetic determinants of puberty onset and more particularly in humans, where several pathologies are associated with puberty delay or advance and in cattle where several groups have now identified genomic regions or gene networks associated with puberty traits. Last but not least, in the last part we will focus on the embryologist point of view, how to get good oocytes for in vitro fertilization and embryo development from younger animals.

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Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Cited by 153 publications

References 244 publications

Nutritional Determinants of the Timing of Puberty

Nutritional Determinants of the Timing of Puberty

Estudio Exploratorio De La Presencia De Microcontaminantes en El Ciclo Urbano Del Agua en Colombia: Caso De Estudio Santiago De Cali

The timing of puberty (oocyte quality and management)

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