Effects of low and moderate treadmill exercise on liver of<scp>d</scp>‐galactose‐exposed aging rat model

Wasityastuti, Widya; Habib, Nurfatma A.; Sari, Dwi Cahyani Ratna; Arfian, Nur

doi:10.14814/phy2.14279

Cited by 6 publications

(8 citation statements)

References 53 publications

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“…It was revealed that D-gal is able to trigger aging-like effects in experimental animals [54][55][56][57]. In fact, the use of D-gal for animal aging models has been intensively utilized for antiaging research worldwide since the early 1990s [58][59][60].…”

Section: Introductionmentioning

confidence: 99%

Galactose-Induced Skin Aging: The Role of Oxidative Stress

Umbayev

Askarova

Almabayeva

et al. 2020

Oxidative Medicine and Cellular Longevity

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Skin aging has been associated with a higher dietary intake of carbohydrates, particularly glucose and galactose. In fact, the carbohydrates are capable of damaging the skin’s vital components through nonenzymatic glycation, the covalent attachment of sugar to a protein, and subsequent production of advanced glycation end products (AGEs). This review is focused on the role of D-galactose in the development of skin aging and its relation to oxidative stress. The interest in this problem was dictated by recent findings that used in vitro and in vivo models. The review highlights the recent advances in the underlying molecular mechanisms of D-galactose-mediated cell senescence and cytotoxicity. We have also proposed the possible impact of galactosemia on skin aging and its clinical relevance. The understanding of molecular mechanisms of skin aging mediated by D-galactose can help dermatologists optimize methods for prevention and treatment of skin senescence and aging-related skin diseases.

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Section: Introductionmentioning

confidence: 99%

Galactose-Induced Skin Aging: The Role of Oxidative Stress

Umbayev

Askarova

Almabayeva

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Mice in the non-exercise group were not exposed to treadmill exercise, and instead performed routine daily activities in housing cages. The intensity of exercise performed was determined based on a percentage of maximal oxygen consumption (%VO2max) index published previously ( Wasityastuti et al, 2019 ). Exercise was performed at an intensity of 85% VO 2max .…”

Section: Methodsmentioning

confidence: 99%

Trabecular Bone Microarchitecture Improvement Is Associated With Skeletal Nerve Increase Following Aerobic Exercise Training in Middle-Aged Mice

et al. 2022

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Advancing age is associated with bone loss and an increased risk of osteoporosis. Exercise training improves bone metabolism and peripheral nerve regeneration, and may play a critical role in osteogenesis and increase in skeletal nerve fiber density. In this study, the potential positive role of aerobic exercise training in bone metabolism and skeletal nerve regeneration was comprehensively evaluated in 14-month-old male C57BL/6 mice. The mice were divided into two groups: no exercise (non-exercise group) and 8-weeks of aerobic exercise training (exercise group), with six mice in each group. Dual-energy X-ray absorptiometry and micro-computed tomography showed that femoral and tibial bone parameters improved after aerobic exercise training. Greater skeletal nerve fiber density was also observed in the distal femoral and proximal tibial periostea, measured and analyzed by immunofluorescence staining and confocal microscopy. Pearson correlation analysis revealed a significant association between skeletal nerve densities and trabecular bone volume/total volume ratios (distal femur; R2 = 0.82, p < 0.05, proximal tibia; R2 = 0.59, p = 0.07) in the exercise group; while in the non-exercise group no significant correlation was found (distal femur; R2 = 0.10, p = 0.54, proximal tibia; R2 = 0.12, p = 0.51). Analysis of archival microarray database confirmed that aerobic exercise training changed the microRNA profiles in the mice femora. The differentially expressed microRNAs reinforce the role of aerobic exercise training in the osteogenic and neurogenic potential of femora and tibiae. In conclusion, 8-weeks of aerobic exercise training positively regulate bone metabolism, an effect that paralleled a significant increase in skeletal nerve fiber density. These findings suggest that aerobic exercise training may have dual utility, both as a direct stimulator of bone remodeling and a positive regulator of skeletal nerve regeneration.

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“…It has been shown that exercise had a significant effect on DGelevated AST and ALT levels of DG-trained rats [36]. Exercise also lowered the degree of DG-exposed hepatic fibrosis, and restore the injured liver tissue back to the non-aging state in DG-exposed aging rats [37]. Exercise training restores Insulin-like growth factor-I receptor (IGFIR) survival signaling in DG-inducedaging rats to suppress cardiac apoptosis [38].…”

Section: Graphical Abstractmentioning

confidence: 99%

Effects of Endurance Training with or without Rosehip Fruits (Rosa canina L) Extraction and D-galactose Solution on Plasmatic Liver Enzymes, Lipid Profiles, Selected Biochemical Variables in Male Rats

Ghanbari–Niaki

Rahmati-Ahmadabad

Broom

et al. 2022

Braz. arch. biol. technol.

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The aims of the present study were to examine the effects of D-galactose (DG) supplementation on plasma aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, albumin, urea, bilirubin, cholesterol, and triglyceride. We also investigated the effects of Rosehip (Rosa canina L) fruit extraction and endurance exercise training on DG-induced changes in the aforementioned variables in male rats. Eighty-six male rats were randomly assigned to 8 groups 1) Control Saline 2) Training Saline 3) Control D-galactose 4) Training D-galactose 5) Control Rosehip 6) Training Rosehip 7) Control combined group and 8) Training combined group. Animals received experiments on the base of groups' names (eight weeks and five times per week). Seventy-two hours after the last training or control session plasma was collected. The results showed that endurance training significantly increased plasma albumin while reducing ALT and creatinine. Rosehip significantly reduced plasma AST, creatinine, urea, cholesterol, and triglyceride, and increased bilirubin. A combination of training and Rosehip causes an additive effect HIGHLIGHTS • Exercise increases plasma albumin, while reducing ALT and creatinine.• Rosehip reduces AST, creatinine, urea, cholesterol, and triglyceride.• D-galactose increases ALT, AST, ALP, creatinine, urea, cholesterol, and triglyceride.• Rosehip adjusts the changes induced by D-galactose on some variables.

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Effects of low and moderate treadmill exercise on liver ofd‐galactose‐exposed aging rat model

Cited by 6 publications

References 53 publications

Galactose-Induced Skin Aging: The Role of Oxidative Stress

Galactose-Induced Skin Aging: The Role of Oxidative Stress

Trabecular Bone Microarchitecture Improvement Is Associated With Skeletal Nerve Increase Following Aerobic Exercise Training in Middle-Aged Mice

Effects of Endurance Training with or without Rosehip Fruits (Rosa canina L) Extraction and D-galactose Solution on Plasmatic Liver Enzymes, Lipid Profiles, Selected Biochemical Variables in Male Rats

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