Effects of isoflavones on lipid and apolipoprotein levels in patients with type 2 diabetes in Heilongjiang Province in China

Abstract

In this study, we examined the association between soy isoflavones and lipid profiles, apolipoprotein levels in patients with type 2 diabetes in China. The study population was composed of 120 cases (80 women with type 2 diabetes and 40 healthy women). Objects in treatment group received isoflavones 435 mg/day for 2 months, then lipid profiles were analyzed by the colorimetry method and apolipoprotein levels were determined by immune turbidimetric method. And all the indexes were determined after oral glucose tolerance test. The levels of total cholesterol, triglyceride and LDL-C significantly reduced and the levels of HDL-C and apolipoprotein A1 significantly raised in the treatment group after intervention (p<0.05). After oral glucose tolerance test, the level of total cholesterol was lower at postprandial 6 h than at empty stomach in treatment group, it had significantly difference (p<0.05). LDL-C levels in the treatment group not only decreased after intervention, but also was significantly lower at postprandial 4, 6 h than in non-intervention group. The ratio of apolipoprotein A1/apolipoprotein B at postprandial 2 h was the highest after treatment in isoflavone group. Supplementation with 435 mg/day of isoflavones exerted favorable effect on the blood total cholesterol, LDL-C levels and the ratio of apolipoprotein A1/apolipoprotein B in Chinese type 2 diabetes women.

Combined effect of body mass index and waist-height ratio on incident diabetes; a population based cohort study

“…In fact, it has been reported that supplementation of soy isoflavones is effective for improving lipid profiles and apolipoprotein levels in patients with type 2 diabetes. ( 31 )…”

Metabolic Engineering of Isoflavones: An Updated Overview

“…In the last few decades, the consumption of isoflavone-rich functional foods is highly recommended owing to the potential health protection against some aging-associated diseases such as cardiovascular disease, osteoporosis, hormone-related cancer, and cognitive impairment ( Gilbert and Liu, 2013 ; Vitale et al, 2013 ; Chi et al, 2016 ) ( Figure 3 ). Even though isoflavones present in a variety of plant-derived products such as cereals, potatoes, vegetables, and fruits, the richest sources in the human diet are soy-derived foods ( Kraszewska et al, 2007 ).…”

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia

“…With regard to lipoproteins, a meta-analysis of 38 objects showed that soy supplementation results in an improvement in total and LDL-C [20], however, the benefit was mainly limited to subjects with very high pretreatment lipids. Furthermore, supplementation with 435 mg/day of isoflavone exerted a favorable effect on the total cholesterol, LDL-C levels and the ratio of apolipoprotein A1/apolipoprotein B in the blood of Chinese type 2 diabetic women [21]. On the basis of these studies, the regulatory effect and pathways of soybean bioactive substances on hyperlipidemic postmenopausal women were further investigated by measuring the protein and mRNA expression levels of LDLR, LXRα, and ABCG1 in hyperlipidemic postmenopausal women using western-blot and quantitative real-time polymerase chain reaction (qRT-PCR), respectively.…”