Effects of intravenous and oral clonidine on hemodynamic and plasma-catecholamine response due to endotracheal intubation

Background: Laparoscopic surgeries, including cholecystectomy are being performed on a large scale owing to the improved tissue healing and minimal hospital stay. However the haemodynamic response to pneumoperitoneum could pose a problem in these patients. The primary objective of this study was to evaluate the effectiveness of 1µg/kg intravenous clonidine in suppression of this hemodynamic response. The secondary objective was to assess the postoperative analgesia and sedation.Methods: 60 patients posted for laparoscopic cholecystectomy were divided into two groups. 30 patients received intravenous midazolam 0.03mg/kg and pentazocine 0.3mg/kg and the other 30 received intravenous clonidine 1µg/kg 15 minutes prior induction.Results: Intraoperative mean pulse rate was 90.82±4.81 beats per minute in control group. In clonidine group it was 74.76±9.88 beats per minute (p<0.05 significant). Similarly the mean systolic blood pressure was 137.87±4.89 and 125.79±6.44 respectively (p<0.05-significant). The duration of postoperative analgesia was 334.83±24.65 and 116.05±19.17 minutes respectively (p<0.05).Conclusions: Premedication with intravenous clonidine, has been found to be relatively safe as well as an effective method that provides stable haemodynamics and protection against stress response induced by pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.

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“…12,13 We did not study this aspect in detail. The efficacy of the drug in a compromised cardiovascular system too was not studied.…”

Section: Discussionmentioning

confidence: 99%

Intravenous clonidine for suppression of haemodynamic response to laparoscopy- a prospective randomised, placebo controlled, single centre study

et al. 2017

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“…Zalunrdo et al has shown that intravenous clonidine was better than oral clonidine in attenuating the pressor response. 10 The effects of clonidine on the hemodynamic parameters are dose related. In the present study 1 g.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of dexmedetomidine with clonidine as premedication for attenuation of hemodynamic responses during laryngoscopy and endotracheal intubation under general anesthesia

et al. 2016

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“…During airway manipulation (Laryngoscopy, intubation, and extubation), there is stimulation of sympathetic nervous system especially under light anaesthesia. 2 Pneumoperitoneum itself and hypercarbia both stimulate the sympathetic nervous system and thereby increase blood pressure, heart rate, and the risk of arrhythmias. 3 Different medications like opioids, benzodiazepines, lignocaine, beta blockers, calcium channel blockers, nitroglycerine, etc.…”

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confidence: 99%

“…7 Intravenous clonidine (3 mcg/kg) administered just prior to intubation has been compared with oral clonidine (4 mcg/kg) given 90 min before induction where intravenous administration was found superior to oral clonidine and placebo for attenuation of stress response to intubation. 2 Clonidine premedication using oral route has been investigated for attenuation of HDR (adrenergic response) of airway instrumentation and pneumoperitoneum. Different doses have been compared in several studies such as 100 mcg vs 200 mcg.…”

mentioning

confidence: 99%

Study of the Role of Oral Clonidine Premedication on Haemodynamic Changes During Laparoscopic Cholecystectomy Under General Anaesthesia With Endotracheal Intubation

Chattopadhyay¹,

Pal²,

Mitra³

et al. 2016

jemds

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BACKGROUNDLaparoscopic cholecystectomy (LC) is known to produce Exaggerated Haemodynamic Responses (HDR) owing to pneumoperitoneum. Different pharmacological agents like opioids, benzodiazepines, lignocaine, beta blockers, nitroglycerine, etc. are being used to alleviate HDR. Clonidine at doses varying from 2 to 6 mcg per kg body weight or a fixed dose of 150 or 200 mcg have been tested either through intravenous or oral routes with varying results thus creating confusion. Hence, we have designed to observe the effect of oral premedication with 200 mcg clonidine in attenuating HDR in patients undergoing LC under GA.

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Effects of intravenous and oral clonidine on hemodynamic and plasma-catecholamine response due to endotracheal intubation

Cited by 40 publications

References 24 publications

Intravenous clonidine for suppression of haemodynamic response to laparoscopy- a prospective randomised, placebo controlled, single centre study

Intravenous clonidine for suppression of haemodynamic response to laparoscopy- a prospective randomised, placebo controlled, single centre study

Comparative evaluation of dexmedetomidine with clonidine as premedication for attenuation of hemodynamic responses during laryngoscopy and endotracheal intubation under general anesthesia

Study of the Role of Oral Clonidine Premedication on Haemodynamic Changes During Laparoscopic Cholecystectomy Under General Anaesthesia With Endotracheal Intubation

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