BACKGROUNDLaparoscopic cholecystectomy (LC) is known to produce Exaggerated Haemodynamic Responses (HDR) owing to pneumoperitoneum. Different pharmacological agents like opioids, benzodiazepines, lignocaine, beta blockers, nitroglycerine, etc. are being used to alleviate HDR. Clonidine at doses varying from 2 to 6 mcg per kg body weight or a fixed dose of 150 or 200 mcg have been tested either through intravenous or oral routes with varying results thus creating confusion. Hence, we have designed to observe the effect of oral premedication with 200 mcg clonidine in attenuating HDR in patients undergoing LC under GA.
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