Comparative evaluation of dexmedetomidine with clonidine as premedication for attenuation of hemodynamic responses during laryngoscopy and endotracheal intubation under general anesthesia

Agarwal, Salony; Gupta, Kumkum; Singh, Vijendra Pal; Sharma, Deepak Kumar; Pandey, MN

doi:10.18203/2320-6012.ijrms20162928

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Various studies have found that dexmedetomidine can decrease the hemodynamic response to laryngoscopy and intubation 16,17 and has shown better results than clonidine. 18,19 Dexmedetomidine has a reversal drug for its sedative effect ie atipamezole, making dexmedetomidine a superior drug compared to clonidine.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study between Two Different Doses of Dexmedetomidine for Attenuation of Hemodynamic Response to Laryngoscopy and Tracheal Intubation.

Thapa

Gauchan

2019

Nep. Med. Coll. J.

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Laryngoscopy and end tracheal intubation are stressful situation for the patients, as these procedures are capable of producing tachycardia, hypertension and arrhythmias. This study was conducted with the objective of arriving at an optimal dose of dexmedetomidine that can attenuate the hemodynamic response to laryngoscopy and intubation with minimal side effects. The current study was conducted in 60 patients, posted for elective surgery under general anesthesia withendotracheal intubation. The patients were divided into two groups: Group A and Group B. Group A received dexmedetomidine 0.5 μg/kg and group B received dexmedetomidine 1 μg/kg intravenously over 10 min prior to induction of anesthesia. The anesthesia technique was standardized in both the groups. Heart rate, systolic, diastolic and mean arterial pressure were monitored and recorded at 5min and 10 min of completion of infusion of study drug, after induction, and at 1 min, 2 min, 5 min after intubation. The baseline heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were statistically similar in both the groups. After the infusion of the study drug the mean heart rate, mean systolic blood pressure, mean diastolic blood pressure, mean arterial pressure at all times were comparable in both the groups. Episodes of hypotension and bradycardia were also statistically similar in both the groups. Attenuation of hemodynamic response to laryngoscopy and intubation by dexmedetomidine is similar with the two doses: 0.5 μg/kg and 1 μg/kg. Both the doses of dexmedetomidine were devoid of any significant adverse effects.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study between Two Different Doses of Dexmedetomidine for Attenuation of Hemodynamic Response to Laryngoscopy and Tracheal Intubation.

Thapa

Gauchan

2019

Nep. Med. Coll. J.

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“…Dexmedetomidine is e ective during intubation at the time of anaesthesia. 1 In addition, it maintained intraoperative cardiovascular stability.…”

Section: Introductionmentioning

confidence: 93%

Efficacy of Different Doses of Dexmedetomidine in Blood Pressure to Laryngoscopy in Controlled Hypertensive Patient: A Randomized Control Trial

Afroz¹,

Begum²,

Alam

et al. 2021

Bangladesh Med J

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Control of blood pressure during anesthesia is very crucial. Laryngoscopic manipulation and endotracheal intubation are always a matter of concern which capable of producing tachycardia, arrhythmias and hypertension which is generally well tolerated in healthy patient. In hypertensive patient cardiovascular response to laryngoscopy and intubation is exaggerated. This study was conducted to assess the efficacy of different doses of dexmedetomidine in reduction of blood pressure during laryngoscopy and intubation in controlled hypertensive patient. This prospective Randomized controlled trial was carried out among 60 patients belonging to American Society of Anesthesiologists (ASA) Physical Status II posted for elective general anesthesia. Patients were randomly divided into three groups where each groups contain twenty with fixed card sampling. Group A consisted of twenty (20) patients who were received IV dexmedetomidine 0.5 µg/kg diluted to 50 ml with normal saline. Group B consisted of twenty (20) patients who were received IV dexmedetomidine 0.75 µg/kg diluted to 50 ml with normal saline. Group C consisted of twenty (20) patients who were received IV dexmedetomidine 1 µg/kg diluted to 50 ml with normal saline. Each infusions were started 10 minutes prior induction of general anesthesia and were given over 10 minutes. Baseline systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) were measured by one volunteer anesthesiologists by non-invasive blood pressure monitor. Following laryngoscopy and endotracheal intubation, the parameters recorded were SBP, DBP and MAP at 1, 3 and 5 min after intubation by non-invasive blood pressure monitor. The primary outcome measures were blood pressure responses after intubation and secondary outcome measures were to note down any adverse effects associated with drugs. In this study baseline readings of SBP, DBP and MAP were almost similar in all three groups and statistically not significant. Maximum intubation response was seen at 1 min post intubation in all the three groups. The mean SBP of group A varied from 144.8±8.4 mmHg to 118.5±4.4 mmHg that of group B varied from 134.8±4.1 to 122.0±4.2 mmHg and then group C varied from 126.5±15.5 mmHg to 103.8±8.4 mmHg during different evaluation period (p<0.05). The mean DBP of group A varied from 91.8±7.6 mmHg to 72.4±5.8 mmHg that of group B varied from 81.3±5.2 to 70.3±2.5 mmHg and then group C varied from 80.9±6.7 mmHg to 63.4±2.4 mmHg during different evaluation period (p<0.05). The mean MAP of group A varied from 109.0±5.6 mmHg to 87.5±4.4 mmHg that of group B varied from 98.7±2.5 to 86.3±3.4 mmHg and then group C varied from 95.5±9.2 mmHg to 76.5±3.4 mmHg during different evaluation period (p<0.05). The mean SBP at 1st hour was found 127.9±6.5 in group A, 131.6±6.4 group B and 131.5±7.1 group C. The DBP at 1st hour was found 126.8±6.4 in Group A, 131.4±6.8 in Group B and 131.8±6.1 in Group C. The mean MAP at 1st hours was found 93.2±3.7 in group A, 95.4±3.4 in Group B and 96.2±4.9 in Group C(p>0.05). Dexmedetomidine in doses of 0.75 µg/kg was more effective compared to 0.05 µg/kg and 1µg/kg in attenuating blood pressure response to laryngoscopy and endotracheal intubation without producing adverse effects in control hypertensive patients. Bangladesh Med J. 2019 Sep; 48 (3): 1-8

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Comparative evaluation of dexmedetomidine with clonidine as premedication for attenuation of hemodynamic responses during laryngoscopy and endotracheal intubation under general anesthesia

Cited by 2 publications

References 8 publications

A Comparative Study between Two Different Doses of Dexmedetomidine for Attenuation of Hemodynamic Response to Laryngoscopy and Tracheal Intubation.

A Comparative Study between Two Different Doses of Dexmedetomidine for Attenuation of Hemodynamic Response to Laryngoscopy and Tracheal Intubation.

Efficacy of Different Doses of Dexmedetomidine in Blood Pressure to Laryngoscopy in Controlled Hypertensive Patient: A Randomized Control Trial

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