Effects of intervals between jumps or bouts on osteogenic response to loading

Umemura, Yoshihisa; Sogo, Naota; Honda, Akira

doi:10.1152/japplphysiol.00358.2002

Cited by 69 publications

(87 citation statements)

References 23 publications

(30 reference statements)

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“…The surprising anabolic effect of inserting a brief zero load interval between each load cycle was subsequently confirmed by our group and others [36][37][38][39]. At the tissue level, we have found that low magnitude rest-inserted loading is even capable of stimulating periosteal bone formation in senescent animals [40].…”

Section: Introductionsupporting

confidence: 72%

32 wk old C3H/HeJ mice actively respond to mechanical loading

Poliachik

Threet

Srinivasan

et al. 2008

Bone

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Numerous studies indicate that C3H/HeJ (C3H) mice are mildly responsive to mechanical loading compared to C57BL/6J (C57) mice. Guided by data indicating high baseline periosteal osteoblast activity in 16 wk C3H mice, we speculated that simply allowing the C3H mice to age until basal periosteal bone formation was equivalent to that of 16 wk C57 mice would restore mechanoresponsiveness in C3H mice. We tested this hypothesis by subjecting the right tibiae of 32 wk old C3H mice and 16 wk old C57 mice to low magnitude rest-inserted loading (peak strain: 1235με) and then exposing the right tibiae of 32 wk C3H mice to low (1085με) or moderate (1875 με) magnitude cyclic loading. The osteoblastic response to loading on the endocortical and periosteal surfaces was evaluated via dynamic histomorphometry. At 32 wk of age, C3H mice responded to low magnitude rest-inserted loading with significantly elevated periosteal mineralizing surface, mineral apposition rate and bone formation compared to unloaded contralateral bones. Surprisingly, the periosteal bone formation induced by low magnitude rest-inserted loading in C3H mice exceeded that induced in 16 wk C57 mice. At 32 wk of age, C3H mice also demonstrated an elevated response to increased magnitudes of cyclic loading. We conclude that a high level of basal osteoblast function in 16 wk C3H mice appears to overwhelm the ability of the tissue to respond to an otherwise anabolic mechanical loading stimulus. However, when basal surface osteoblast activity is equivalent to that of 16 wk C57 mice, C3H mice demonstrate a clear ability to respond to either rest-inserted or cyclic loading.

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Section: Introductionsupporting

confidence: 72%

32 wk old C3H/HeJ mice actively respond to mechanical loading

Poliachik

Threet

Srinivasan

et al. 2008

Bone

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“…We have previously shown that an intermittent training stimulus consisting of 10 min of activity followed by 6 h of rest resulted in greater collagen synthesis than continuous activity in engineered ligaments (27). For bone, as few as 40 loads/d delivered in short bouts with 6-8 h of rest maximizes mineralization in rodents (37,(45)(46)(47)(48)(49)(50). In humans, as few as 10 maximal vertical jumps/d performed 3 d/wk is enough to increase bone mineral density in female college students (51).…”

Section: Figurementioning

confidence: 99%

Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis

Shaw¹,

Lee-Barthel

Ross

et al. 2017

The American Journal of Clinical Nutrition

137

178

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“…Studies of rats running on treadmills 18,19,50,78 and performing repetitive jumping 114 have shown that increasing the intensity of weight-bearing exercise is associated with diminishing returns in biomechanical competence, mass, and bone morphology of vertebral and limb bones. Periosteal and marrow edema as well as tibial stress fractures have been reported in runners with shin splints.…”

Section: Pathophysiology Of Wmsds Evidence Of Musculoskeletal Injury mentioning

confidence: 99%

Work-Related Musculoskeletal Disorders of the Hand and Wrist: Epidemiology, Pathophysiology, and Sensorimotor Changes

Barr

Barbe²,

Clark³

2004

J Orthop Sports Phys Ther

197

111

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The purpose of this commentary is to present recent epidemiological findings regarding work-related musculoskeletal disorders (WMSDs) of the hand and wrist, and to summarize experimental evidence of underlying tissue pathophysiology and sensorimotor changes in WMSDs. Sixty-five percent of the 333 800 newly reported cases of occupational illness in 2001 were attributed to repeated trauma. WMSDs of the hand and wrist are associated with the longest absences from work and are, therefore, associated with greater lost productivity and wages than those of other anatomical regions. Selected epidemiological studies of hand/wrist WMSDs published since 1998 are reviewed and summarized. Results from selected animal studies concerning underlying tissue pathophysiology in response to repetitive movement or tissue loading are reviewed and summarized. To the extent possible, corroborating evidence in human studies for various tissue pathomechanisms suggested in animal models is presented. Repetitive, handintensive movements, alone or in combination with other physical, nonphysical, and nonoccupational risk factors, contribute to the development of hand/wrist WMSDs. Possible pathophysiological mechanisms of tissue injury include inflammation followed by repair and/or fibrotic scarring, peripheral nerve injury, and central nervous system reorganization. Clinicians should consider all of these pathomechanisms when examining and treating patients with hand/wrist WMSDs.

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Effects of intervals between jumps or bouts on osteogenic response to loading

Cited by 69 publications

References 23 publications

32 wk old C3H/HeJ mice actively respond to mechanical loading

32 wk old C3H/HeJ mice actively respond to mechanical loading

Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis

Work-Related Musculoskeletal Disorders of the Hand and Wrist: Epidemiology, Pathophysiology, and Sensorimotor Changes

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