Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis

Shaw, Gregory; Lee-Barthel, Ann; Ross, Megan L.; Wang, Bing; Baar, Keith

doi:10.3945/ajcn.116.138594

Cited by 142 publications

(217 citation statements)

References 50 publications

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“…In humans, consuming gelatin 1 h before a short period of mechanical loading is able to double the amount of the amino-terminal propeptide (Procollagen I N-terminal Propeptide) of type I collagen in the blood [191]. This indicates that gelatin can improve the collagen synthesis response to loading.…”

Section: Gelatin/collagen and Vitamin Cmentioning

confidence: 99%

Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview

et al. 2017

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Team sport athletes face a variety of nutritional challenges related to recovery during the competitive season. The purpose of this article is to review nutrition strategies related to muscle regeneration, glycogen restoration, fatigue, physical and immune health, and preparation for subsequent training bouts and competitions. Given the limited opportunities to recover between training bouts and games throughout the competitive season, athletes must be deliberate in their recovery strategy. Foundational components of recovery related to protein, carbohydrates, and fluid have been extensively reviewed and accepted. Micronutrients and supplements that may be efficacious for promoting recovery include vitamin D, omega-3 polyunsaturated fatty acids, creatine, collagen/vitamin C, and antioxidants. Curcumin and bromelain may also provide a recovery benefit during the competitive season but future research is warranted prior to incorporating supplemental dosages into the athlete’s diet. Air travel poses nutritional challenges related to nutrient timing and quality. Incorporating strategies to consume efficacious micronutrients and ingredients is necessary to support athlete recovery in season.

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Section: Gelatin/collagen and Vitamin Cmentioning

confidence: 99%

Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview

et al. 2017

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“…We have now begun feeding gelatin to people and have seen extremely positive responses on collagen production and return to play in athletes after injury. In fact, in a randomized, double-blind crossover clinical trial, we found that ingestion of 15 g of gelatin 1 h before 6 min of jump rope is able to double collagen synthesis [46]. Further, serum taken before or 1 h after feeding a placebo or 5 or 15 g of vitamin C-enriched gelatin results in a dose-dependent increase in collagen in engineered ligaments [46].…”

Section: Nutritional Interventions To Improve Soft-tissue Functionmentioning

confidence: 99%

“…In fact, in a randomized, double-blind crossover clinical trial, we found that ingestion of 15 g of gelatin 1 h before 6 min of jump rope is able to double collagen synthesis [46]. Further, serum taken before or 1 h after feeding a placebo or 5 or 15 g of vitamin C-enriched gelatin results in a dose-dependent increase in collagen in engineered ligaments [46]. These data support the use of gelatin as a nutritional intervention to increase collagen synthesis in sinew and bone.…”

Section: Nutritional Interventions To Improve Soft-tissue Functionmentioning

confidence: 99%

“…However, because blood flow to inactive tendons is limited, nutrient delivery to tendons following exercise is believed to be relatively low. This suggests that any nutritional intervention that is designed to directly target a specific tendon/ligament needs to be in place prior to exercise.Thirty to sixty minutes before training, athletes should be encouraged to consume 15 g of gelatin in either a liquid or gel form [46]. The exact amount of gelatin and whether this will vary with body weight is currently being determined.…”

Section: Conclusion and Science-based Recommendations For Training Tmentioning

confidence: 99%

“…Thirty to sixty minutes before training, athletes should be encouraged to consume 15 g of gelatin in either a liquid or gel form [46]. The exact amount of gelatin and whether this will vary with body weight is currently being determined.…”

Section: Conclusion and Science-based Recommendations For Training Tmentioning

confidence: 99%

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Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments

Baar

2017

Sports Med

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Musculoskeletal injuries account for more than 70% of time away from sports. One of the reasons for the high number of injuries and long return to play is that we have only a very basic understanding of how our training alters tendon and ligament (sinew) structure and function. Sinews are highly dense tissues that are difficult to characterize both in vivo and in vitro. Recently, engineered ligaments have been developed in vitro using cells from human anterior cruciate ligaments or hamstring tendons. These three-dimensional tissues can be grown in a laboratory, treated with agents thought to affect sinew physiology, and then mechanically tested to determine their function. Using these tissues, we have learned that sinews, like bone, quickly become refractory to an exercise stimulus, suggesting that short (<10 min) periods of activity with relatively long (6 h) periods of rest are best to train these tissues. The engineered sinews have also shown how estrogen decreases sinew function and that a factor released following intense exercise increases sinew collagen synthesis and function. Last, engineered sinews are being used to screen possible nutritional interventions that may benefit tendon or ligament function. Using the data derived from these tissue-engineered sinews, new nutritional and training regimes are being designed and tested with the goal of minimizing injury and accelerating return to play.

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Metabolic Response Modulations by Zwitterionic Hydrogels for Achieving Promoted Bone Regeneration

Li,

Yue,

Peng

et al. 2023

Adv Funct Materials

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Zwitterionic materials containing both cationic and anionic ligands have been reported to promote hydroxyapaptite (HA)‐mineralization. However, how zwitterionic microenvironment regulates osteogenesis of bone marrow mesenchymal stem cells (BMSCs) and bone regeneration remains elusive. Here, a strategy using zwitterionic (2‐(N‐3‐sulfopropyl‐N, N‐dimethyl ammonium) ethyl methacrylate/ Methacrylated gelatin (DMAPS/GelMA) hydrogel to promote osteogenic differentiation of BMSCs in vitro and enhance bone defect repair in vivo is developed. This zwitterionic hydrogel exhibits high stereo‐affinity of fibronectin III7‐10 (FnIII7‐10) and accelerates endogenous stem cell recruitment during bone regeneration. Then, the metabolic architecture of zwitterion‐guided osteogenesis is explored by using precise untargeted metabolomics, and the metabolic profile is mapped in the zwitterionic microenvironment. The zwitterion‐dependent energetic metabolic profile reveals that amino acids capable of promoting osteogenesis, such as proline and hydroxyproline, are enriched in zwitterionic extracellular matrix (ECM); whereas, fatty acids suggestting the inflammatory response, such as dinoprostone and prostaglandin h2, are enriched in either positive‐charged ECM or negative‐charged ECM. This zwitterionic ECM‐dependent metabolic landscape is the underlying mechanism of zwitterionic hydrogel‐promoted osteogenic differentiation of BMSCs. Therefore, the study provides a deeper contextual understanding of zwitterionic‐directed bone regeneration, leading to stereochemical principles of valuable functionalized biomaterial design.

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Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis

Cited by 142 publications

References 50 publications

Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview

Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview

Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments

Metabolic Response Modulations by Zwitterionic Hydrogels for Achieving Promoted Bone Regeneration

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