Effects of insulin treatment on the response to oleate and octanoate of food intake and fatty acid–sensing systems in rainbow trout

Librán-Pérez, Marta; Velasco, Cristina; Otero-Rodiño, Cristina; López‐Patiño, Marcos A.; Míguez, Jesús M.; Soengas, José L.

doi:10.1016/j.domaniend.2015.06.004

Cited by 19 publications

(14 citation statements)

References 47 publications

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“…Therefore, not surprisingly, many studies evaluated the effects of different dietary lipids in fish metabolism (Morash et al, 2009; Torstensen et al, 2009; Sánchez-Gurmaches et al, 2010; Figueiredo-Silva et al, 2012a,b,c; Martinez-Rubio et al, 2013). However, only recent studies provide evidence for the presence of fatty acid sensing systems in central areas of rainbow trout (Librán-Pérez et al, 2012, 2013a, 2014a,b, 2015a,b) and Senegalese sole (Conde-Sieira et al, 2015a) as well as in peripheral areas of rainbow trout (Librán-Pérez et al, 2012, 2013a,b,c, 2015c). …”

Section: Nutrient Sensing Mechanisms In Fishmentioning

confidence: 99%

“…Insulin treatment resulted in contradictory effects in food intake in fish. In rainbow trout IP administration of insulin inhibited (Librán-Pérez et al, 2015a) or activated (Polakof et al, 2008a; Conde-Sieira et al, 2010b) food intake whereas ICV treatment with insulin inhibited food intake in rainbow trout (Soengas and Aldegunde, 2004) but not in catfish (Silverstein and Plisetskaya, 2000). The putative anorectic effects of insulin would be in agreement with the increased anorexigenic potential elicited by insulin treatment as demonstrated increased mRNA abundance of CART in rainbow trout (Librán-Pérez et al, 2015a) and catfish (Subhedar et al, 2011) as well as decreased NPY mRNA abundance in rainbow trout (Librán-Pérez et al, 2015a).…”

Section: Endocrine Modulation Of Nutrient Sensingmentioning

confidence: 99%

“…In rainbow trout IP administration of insulin inhibited (Librán-Pérez et al, 2015a) or activated (Polakof et al, 2008a; Conde-Sieira et al, 2010b) food intake whereas ICV treatment with insulin inhibited food intake in rainbow trout (Soengas and Aldegunde, 2004) but not in catfish (Silverstein and Plisetskaya, 2000). The putative anorectic effects of insulin would be in agreement with the increased anorexigenic potential elicited by insulin treatment as demonstrated increased mRNA abundance of CART in rainbow trout (Librán-Pérez et al, 2015a) and catfish (Subhedar et al, 2011) as well as decreased NPY mRNA abundance in rainbow trout (Librán-Pérez et al, 2015a). As for insulin capacity to modulate the activity of nutrient sensing systems, its administration in rainbow trout inhibits glucosensing response in hypothalamus, hindbrain, BB, and intestine (Polakof et al, 2007a, 2008a, 2010b; Conde-Sieira et al, 2010b).…”

Section: Endocrine Modulation Of Nutrient Sensingmentioning

confidence: 99%

“…As for insulin capacity to modulate the activity of nutrient sensing systems, its administration in rainbow trout inhibits glucosensing response in hypothalamus, hindbrain, BB, and intestine (Polakof et al, 2007a, 2008a, 2010b; Conde-Sieira et al, 2010b). As for fatty acid sensing systems, no clear effects of insulin treatment were observed in rainbow trout hypothalamus (Librán-Pérez et al, 2015a), in contrast to mammals (Duca and Yue, 2014). However, in liver and BB insulin treatment potentiates the effect of oleate and octanoate on fatty acid sensing systems (Librán-Pérez et al, 2015a).…”

Section: Endocrine Modulation Of Nutrient Sensingmentioning

confidence: 99%

See 3 more Smart Citations

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

2017

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Evidence obtained in recent years in a few species, especially rainbow trout, supports the presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central (hypothalamus and hindbrain) and peripheral [liver, Brockmann bodies (BB, main accumulation of pancreatic endocrine cells in several fish species), and intestine] locations whereas fatty acid sensors seem to be present in hypothalamus, liver and BB. Glucose and fatty acid sensing capacities relate to food intake regulation and metabolism in fish. Hypothalamus is as a signaling integratory center in a way that detection of increased levels of nutrients result in food intake inhibition through changes in the expression of anorexigenic and orexigenic neuropeptides. Moreover, central nutrient sensing modulates functions in the periphery since they elicit changes in hepatic metabolism as well as in hormone secretion to counter-regulate changes in nutrient levels detected in the CNS. At peripheral level, the direct nutrient detection in liver has a crucial role in homeostatic control of glucose and fatty acid whereas in BB and intestine nutrient sensing is probably involved in regulation of hormone secretion from endocrine cells.

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Section: Nutrient Sensing Mechanisms In Fishmentioning

confidence: 99%

Section: Endocrine Modulation Of Nutrient Sensingmentioning

confidence: 99%

Section: Endocrine Modulation Of Nutrient Sensingmentioning

confidence: 99%

Section: Endocrine Modulation Of Nutrient Sensingmentioning

confidence: 99%

See 2 more Smart Citations

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

2017

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“…In fish, it was reported that the glucosensor mechanism dependent on GCK-GLUT2-K ATP is modulated at the hypothalamic level by insulin (19), leptin (20), ghrelin (21), cholecystokinin (22), and glucagon-like peptide 1 (23). Insulin (24) and ghrelin (25) have been also found to modulate fatty acid sensing mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

et al. 2018

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Nesfatin-1 is an 82 amino acid peptide that has been involved in a wide variety of physiological functions in both mammals and fish. This study aimed to elucidate the role of nesfatin-1 on rainbow trout food intake, and its putative effects on glucose and fatty acid sensing systems. Intracerebroventricular administration of 25 ng/g nesfatin-1 resulted in a significant inhibition of appetite, likely mediated by the activation of central POMC and CART. Nesfatin-1 stimulated the glucosensing machinery (changes in sglt1, g6pase, gsase, and gnat3 mRNA expression) in the hindbrain and hypothalamus. Central fatty acid sensing mechanisms were unaltered by nesfatin-1, but this peptide altered the expression of mRNAs encoding factors regulating lipid metabolism (fat/cd36, acly, mcd, fas, lpl, pparα, and pparγ), suggesting that nesfatin-1 promotes lipid accumulation in neurons. In the liver, intracerebroventricular nesfatin-1 treatment resulted in decreased capacity for glucose use and lipogenesis, and increased the potential of fatty acid oxidation. Altogether, the present results demonstrate that nesfatin-1 is involved in the homeostatic regulation of food intake and metabolism in fish.

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Fatty acids of different nature differentially modulate feed intake in rainbow trout

Calo

Conde-Sieira²,

Comesaña³

et al. 2023

Aquaculture

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Effects of insulin treatment on the response to oleate and octanoate of food intake and fatty acid–sensing systems in rainbow trout

Cited by 19 publications

References 47 publications

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

Fatty acids of different nature differentially modulate feed intake in rainbow trout

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