Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

Blanco, Ayelén Melisa; Velasco, Cristina; Bertucci, Juan Ignacio; Soengas, José L.; Unniappan, Suraj

doi:10.3389/fendo.2018.00484

Cited by 19 publications

(8 citation statements)

References 79 publications

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“…20 This, along with the fact that nesfatin-1 can cross the blood-brain barrier, 21,22 suggests that nesfatin-1 may have pleiotropic effects. In addition to maintaining the feeding balance, this peptide plays an important role in glucose homeostasis, 23 lipid metabolism, 24 modulation of gastrointestinal functions, 25 cardiovascular, 9 and reproductive functions. 26 It may also be involved in epilepsy, 27 psychological disorders, including stress, 28 sleep disorders, 29 anxiety, 30 and depression.…”

Section: Functions Of Nesfatin-1mentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, antiinflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

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Section: Functions Of Nesfatin-1mentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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“…Nesfatin-1 stimulates fatty-acid oxidation by activating AMP-activated protein kinase in diabetic rats [33], chronic subcutaneous infusion of nesfatin-1 reduced plasma cholesterol and triglyceride and elevate HDL-c levels in other animal models [21,34]. Central nesfatin-1 in the brain may reduce the lipogenic activity and enhance fatty acid oxidation in the rainbow trout liver [35]. Theoretically, anti-atherogenic effect of nesfatin-1 may be mediated via by its anti-oxidant and anti-inflammatory properties and its enhancing effect on insulin sensitivity [4,5,36].…”

Section: Discussionmentioning

confidence: 99%

Serum nesfatin-1 is a biomarker of pre-diabetes and interplays with cardiovascular risk factors

et al. 2022

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Background and objectives Nesfatin-1 as a potent anorexigenic peptide is secreted by pancreatic β cells. Conflicting data are available about its level among diabetic patients. Our study aimed to assess nesfatin-1 levels in newly diagnosed drug-naïve diabetic and pre-diabetic patients and its association with cardio-metabolic risk and insulin resistance (IR). This case-control study included drug-naive patients with DMT2 (group 1, n = 30) and pre-diabetes (group 2, n = 30) in addition to healthy subjects (group 3, n = 28). Anthropometric and routine biochemical assessments were performed. Serum nesfatin-1and plasma insulin levels were assessed by ELISA methods. Homeostatic model for assessment of IR (HOMA-IR) was calculated. Results Serum nesfatin-1 was significantly lower in diabetic and pre-diabetic compared to healthy subjects (3.89 ± 1.1 ng/dl and 7.47 ± 1.22 ng/dl versus 15.39 ± 3.53 respectively, p < 0.001). Also diabetic patients had statistically significant lower nesfatin-1 levels than pre-diabetic patients (p < 0.001) Roc curve analysis identified cut-off values of ≤ 9 ng/dl and ≤ 5.5 ng/dl with an AUC of 0.94 and 0.97, sensitivity of 96.7 and 100%, and specificity of 93.3% and 96.7% for diagnosis of pre-diabetes and diabetes respectively. Using bivariate analysis, nesfatin-1 was negatively correlated with glycemic parameters (fasting and 2 h postprandial blood sugar, HBA1c), IR parameters (fasting insulin and HOMA-IR) and atherogenic lipid profile (triglyceride, cholesterol, and LDL-c); and positively correlated to HDL-c in both diabetic and pre-diabetic but not in healthy. Conclusion Nesfatin-1 is an excellent predictor for pre-diabetes and DMT2. It is associated with favorable glucose and lipid metabolism probably via insulin signaling pathway.

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“…Over the last decade, significant information on the biological actions of nesfatin-1 has been reported in vertebrates, including fish. The main physiological roles of nesfatin-1 in fish include regulation of food intake [1,2], pituitary and gonadal hormone synthesis and/or secretion [3][4][5], cardiovascular functions [6], and oocyte maturation [5]. Research using zebrafish in our lab identified a nesfatin-1-like peptide (Nlp), which is processed from a precursor nucleobindin-1 (NUCB1) that has very high amino acid sequence similarity with NUCB2 [7].…”

Section: Introductionmentioning

confidence: 99%

Tissue-Specific Modulation of Gluco- and Growth-Regulatory Factor Abundance by Nesfatin-1 and Nesfatin-1-like Peptide in Goldfish

Rajeswari

Unniappan

2023

Animals

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Nesfatin-1 and nesfatin-1-like peptide (Nlp) are derived from precursors nucleobindin-2 and -1, two calcium and DNA binding proteins, respectively. Both peptides exhibit hormone-like actions in mammals and fish. These functions include insulinotropic effects of nesfatin-1 and Nlp seen in mice and their growth hormone suppressive actions reported in goldfish. We hypothesized that nesfatin-1 and Nlp are insulin stimulatory (in adipose tissue) and modulate growth hormone and insulin-like growth factors and glucose transporters in goldfish. To test this, goldfish were intraperitoneally injected with either nesfatin-1 or Nlp (50 ng/g BW) or saline alone (control) and sampled at one-hour post-injection (in vivo study). In a separate study, tissue samples were collected and were incubated with either nesfatin-1 or Nlp for one or six hours (in vitro study). Transcript (mRNA) abundance data from the adipose tissue suggest that both nesfatin-1 and Nlp significantly upregulate the abundance of preproinsulin, insulin receptors, and pcsk1 and pcsk2 mRNAs. Meanwhile, the abundance of preproglucagon mRNA in the adipose tissue was significantly downregulated in both in vivo and in vitro studies. These results agree with the insulinotropic and glucagonostatic roles for nesfatin-1 and Nlp reported in rodents. The transcript abundance of growth regulators (igf1, igf2a, and ghra) and glucose transporters (slc2a2 and slc5a1) were upregulated in the muscle, while an opposite effect on these mRNAs was found in the liver of goldfish following nesfatin-1 and Nlp administration. Our results suggest that both nesfatin-1 and Nlp have tissue-specific regulatory roles on growth and glucoregulatory elements in the liver and muscle of goldfish. This agrees with our previous studies that showed a suppressive action of nesfatin-1 on growth hormone in goldfish liver. The results presented here provide strong supportive/confirmatory evidence for tissue-specific insulinotropic and gluco- and growth-regulatory actions of nesfatin-1 and Nlp in goldfish.

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Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

Cited by 19 publications

References 79 publications

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Serum nesfatin-1 is a biomarker of pre-diabetes and interplays with cardiovascular risk factors

Tissue-Specific Modulation of Gluco- and Growth-Regulatory Factor Abundance by Nesfatin-1 and Nesfatin-1-like Peptide in Goldfish

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