Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

Conde-Sieira, Marta; Soengas, José L.

doi:10.3389/fnins.2016.00603

Cited by 101 publications

(68 citation statements)

References 279 publications

(539 reference statements)

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“…Our results show that nesfatin-1 mainly activates glucosensing mechanisms in the rainbow trout brain, as demonstrated by the enhanced expression of sglt1, g6pase , and gsase , and the reduced expression of gnat3 (only in hindbrain), results in general agreement with those observed in the same regions of rainbow trout subjected to glucose challenges (1, 3). This appears to be the first time in any vertebrates in which nesfatin-1 has been reported to modulate parameters involved in central glucosensing.…”

Section: Discussionsupporting

confidence: 89%

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

et al. 2018

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Nesfatin-1 is an 82 amino acid peptide that has been involved in a wide variety of physiological functions in both mammals and fish. This study aimed to elucidate the role of nesfatin-1 on rainbow trout food intake, and its putative effects on glucose and fatty acid sensing systems. Intracerebroventricular administration of 25 ng/g nesfatin-1 resulted in a significant inhibition of appetite, likely mediated by the activation of central POMC and CART. Nesfatin-1 stimulated the glucosensing machinery (changes in sglt1, g6pase, gsase, and gnat3 mRNA expression) in the hindbrain and hypothalamus. Central fatty acid sensing mechanisms were unaltered by nesfatin-1, but this peptide altered the expression of mRNAs encoding factors regulating lipid metabolism (fat/cd36, acly, mcd, fas, lpl, pparα, and pparγ), suggesting that nesfatin-1 promotes lipid accumulation in neurons. In the liver, intracerebroventricular nesfatin-1 treatment resulted in decreased capacity for glucose use and lipogenesis, and increased the potential of fatty acid oxidation. Altogether, the present results demonstrate that nesfatin-1 is involved in the homeostatic regulation of food intake and metabolism in fish.

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Section: Discussionsupporting

confidence: 89%

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

et al. 2018

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“…In a second experiment, we assessed whether the presence of ceramides might alter the effects of GHRL treatment, through joint treatment of GHRL with ceramide. In the different groups, we evaluated in the hypothalamus and hindbrain changes in parameters related to fatty acid sensing, neuropeptide mRNA abundance and cellular signalling pathways, all of which are involved in the control of food intake in fish (Conde-Sieira and Soengas, 2017). The results obtained suggest a differential pattern of response of these factors compared with the known mammalian models.…”

Section: Introductionmentioning

confidence: 96%

“…This is a conserved mechanism in vertebrates, as described in mammals (Blouet and Schwartz, 2010) and fish (Volkoff, 2016). The information provided by nutrient-sensing systems is one of the main processes involved in hypothalamic integration (Efeyan et al, 2015), and the mechanisms involved have been partially characterized in fish (Soengas, 2014;Conde-Sieira and Soengas, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…The function of nutrient-sensing systems and their impact on food intake regulation can be modulated by the action of peripheral hormones in mammals (Blouet and Schwartz, 2010;Morton et al, 2014) and fish (Soengas, 2014;Conde Sieira and Soengas, 2017). One of these hormones is the gastrointestinal peptide ghrelin (GHRL), which binds to mammalian hypothalamus, eliciting an orexigenic response.…”

Section: Introductionmentioning

confidence: 99%

“…A schematic drawing summarizing five main fatty acid-sensing systems in fish including the enzymes involved (Soengas, 2014;Conde-Sieira and Soengas, 2017) and their effects on food intake is shown in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

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Ceramide counteracts the effects of ghrelin on the metabolic control of food intake in rainbow trout

Velasco

Moreiras

Conde-Sieira

et al. 2017

Journal of Experimental Biology

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In mammals, ceramides are involved in the modulation of the orexigenic effects of ghrelin (GHRL). We previously demonstrated in rainbow trout that intracerebroventricular (ICV) treatment with ceramide (2.5 µg/100 g fish) resulted in an anorexigenic response, i.e. a response opposed to that described in mammals, where ceramide treatment is orexigenic. Therefore, we hypothesized that the putative interaction between GHRL and ceramide must be different in fish. Accordingly, in a first experiment, we observed that ceramide levels in the hypothalamus of rainbow trout did not change after ICV treatment with GHRL. In a second experiment, we assessed whether the effects of GHRL treatment on the regulation of food intake in rainbow trout changed in the presence of ceramide. Thus, we injected ICV GHRL and ceramide alone or in combination to evaluate in hypothalamus and hindbrain changes in parameters related to the metabolic control of food intake. The presence of ceramide generally counteracted the effects elicited by GHRL on fatty acid-sensing systems, the capacity of integrative sensors (AMPK, mTOR and SIRT-1), proteins involved in cellular signalling pathways (Akt and FoxO1) and neuropeptides involved in the regulation of food intake (AgRP, NPY, POMC and CART). The results are discussed in the context of regulation of food intake by metabolic and endocrine inputs.

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Premises for a digital twin of the Atlantic salmon in its world: Agency, robustness, subjectivity and prediction

Budaev,

Dumitru,

Enberg

et al. 2024

Aquaculture Fish & Fisheries

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Aquaculture of Atlantic salmon Salmo salar is in transition to precision fish farming and digitalization. As it is easier, cheaper and safer to study a digital replica than the system itself, a model of the fish can potentially improve monitoring and prediction of facilities and operations and replace live fish in many what‐if experiments. Regulators, consumers and voters also want insight into how it is like to be a salmon in aquaculture. However, such information is credible only if natural physiology and behaviour of the living fish is adequately represented. To be able to predict salmon behaviour in unfamiliar, confusing and stressful situations, the modeller must aim for a sufficiently realistic behavioural model based on the animal's proximate robustness mechanisms. We review the knowledge status and algorithms for how evolution has formed fish to control decisions and set priorities for behaviour and ontogeny. Teleost body control is through genes, hormones, nerves, muscles, sensing, cognition and behaviour, the latter being agentic, predictive and subjective, also in a man‐made environment. These are the challenges when constructing the digital salmon. This perspective is also useful for modelling other domesticated and wild animals in Anthropocene environments.

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Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

Cited by 101 publications

References 279 publications

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

Ceramide counteracts the effects of ghrelin on the metabolic control of food intake in rainbow trout

Premises for a digital twin of the Atlantic salmon in its world: Agency, robustness, subjectivity and prediction

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