Effects of inflammatory changes in the middle ear mucosa on middle ear total pressure

Uchimizu, Hirotaka

doi:10.1080/00016480701200228

Cited by 6 publications

(6 citation statements)

References 17 publications

(18 reference statements)

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“…The maximal total ME pressure observed by Aoki et al (1998) was the total pressure measured at the peak mentioned above. Uchimizu (2007) later found similar correlations between the level of the maximal total ME pressure and the condition of the ME using an animal model of otitis media. He found that the maximal total ME pressure was lower in inflamed MEs than in healthy MEs.…”

Section: Possible Clinical Applicationssupporting

confidence: 57%

“…Moreover, a higher grade of inflammation was correlated with a lower value of the same parameter. Thus, theoretically, after having a known ''normal range" (=non-inflamed) at hand, measuring rates of gas exchange using our system, could also help to discriminate (in a non-invasive way) between non-inflamed MEs (where the tympanic membrane was perforated due to trauma) and inflamed MEs and could perhaps give further information regarding the grade of inflammation, in a similar way to that mentioned by Uchimizu (2007).…”

Section: Possible Clinical Applicationsmentioning

confidence: 91%

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Perfusion and diffusion limitations in middle ear gas exchange: The exchange of CO2 as a test case

Marcusohn

Dirckx

2010

Hearing Research

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Section: Possible Clinical Applicationssupporting

confidence: 57%

Section: Possible Clinical Applicationsmentioning

confidence: 91%

Perfusion and diffusion limitations in middle ear gas exchange: The exchange of CO2 as a test case

Marcusohn

Dirckx

2010

Hearing Research

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“…In a study, 51 of 137 patients had mucosal swelling or granulation tissue in the middle ear cavity and the hearing results were poorer in these patients than those with normal middle ear mucosa [12]. Because transmucosal gas exchange is passive and is caused by a partial pressure gradient between the middle ear cavity and the mucosal capillaries, such mucosal exchange is impaired by inflammatory change in the middle ear mucosa and mastoid [13,14]. Furthermore, gas exchange via the mucosa seems to be less impaired than gas exchange via the Eustachian tube.…”

Section: Discussionmentioning

confidence: 98%

Influence of middle ear mucosal condition on post-tympanoplasty audiologic outcome

Song

Hong

Yoon

2015

Eur Arch Otorhinolaryngol

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In this study, the association between the middle ear mucosal condition and post-tympanoplasty audiologic outcome was investigated in patients with chronic otitis media without cholesteatoma. One hundred and forty-three patients with chronic otitis media were collected in the Department of Otorhinolaryngology-Head and Neck Surgery at Asan Medical Center between January, 2009 and December, 2011. In the course of tympanoplasty, the status of the middle ear mucosa was divided into normal or abnormal by one surgeon. Pure tone audiometry was performed preoperatively and postoperatively, and post-tympanoplasty tympanogram was also conducted to estimate the condition of middle ear cavity. Of the 143 patients, there were 73 patients with normal middle ear mucosa and 70 patients with abnormal middle ear mucosa around Eustachian tube opening. The mean ABG of subjects with normal middle ear mucosa was 20.1 dB preoperatively, and 9.7 dB postoperatively (p < 0.001). Preoperative mean ABG was 22.4 dB and postoperative mean ABG was 16.4 dB in abnormal middle ear mucosa group (p = 0.137). Postoperative ABGs for 500 and 1000 Hz (7.1, 7.7 dB) in normal middle ear mucosa patients were significantly lower than those (17.2, 19.4 dB) in abnormal middle ear mucosa patients (p < 0.001). There was statistically significant correlation between middle ear mucosa status and post-tympanoplasty audiologic outcomes. The better condition of middle ear ventilation, the better postoperative hearing thresholds revealed after tympanoplasty.

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“…The hearing results were poorer in these patients than they were in those with intact middle ear mucosa. Because transmucosal gas exchange is passive and is caused by a partial pressure gradient between the middle ear cavity and the mucosal capillaries, such mucosal exchange is impaired by inflammatory changes in the middle ear mucosa and mastoid (13, 14). Furthermore, gas exchange via the mucosa seems to be less impaired than is gas exchange via the ET (14).…”

Section: Discussionmentioning

confidence: 99%

Pre-operative Evaluation of Eustachian Tube Function Using a Modified Pressure Equilibration Test is Predictive of Good Postoperative Hearing and Middle Ear Aeration in Type 1 Tympanoplasty Patients

Choi

Han

Chung

2009

Clin Exp Otorhinolaryngol

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ObjectivesThe Eustachian tube (ET) plays an important role in maintaining a normally aerated middle ear. Inflammation in middle ear disease is related to ET dysfunction, and postoperative restoration of middle ear integrity and hearing are closely related to ET function in chronic ear disease patients. After successful tympanoplasty, restoration of a well-aerated middle ear with good ET function can permit better compliance of the tympanic membrane. In this study, we evaluated the predictive validity of preoperative ET function measurements.MethodsWe reviewed 137 patients who underwent type 1 tympanoplasty. All patients had non-cholesteatomatous chronic otitis media and received canal wall-up-type tympanomastoidectomies. Patients were categorized into four groups according to preoperative ET function measurements using a modified pressure inflation-deflation equilibration test. Group I patients had residual pressures less than 10 daPa, and Group IV patients showed no pressure change (poor results). Groups II and III were intermediate. Hearing levels were determined using pure tone averages at four frequencies. Postoperative tympanography was performed to determine middle ear aeration.ResultsThe preoperative air bone (AB) gap was 29.6±7.0 dB, and the postoperative gap was 16.5±5.7 dB; thus, there was significant overall improvement. In all groups, hearing was significantly better after surgery, but the worst postoperative hearing level was seen in Group IV patients. Type B tympanograms were more frequently recorded in Group IV patients than they were in Group I or II patients. Postoperative AB gaps were 9.2±3.8 dB in patients with type A tympanograms, 13.4±2.1 dB in those with type As, 24.1±2.5 dB in those with type C, and 18.5±2.8 dB in those with type B.ConclusionET function measured with a modified pressure equilibration test using an inflation-deflation manometric method is a good indicator of an aerated middle ear and is predictive of improved postoperative hearing.

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Effects of inflammatory changes in the middle ear mucosa on middle ear total pressure

Cited by 6 publications

References 17 publications

Perfusion and diffusion limitations in middle ear gas exchange: The exchange of CO2 as a test case

Perfusion and diffusion limitations in middle ear gas exchange: The exchange of CO2 as a test case

Influence of middle ear mucosal condition on post-tympanoplasty audiologic outcome

Pre-operative Evaluation of Eustachian Tube Function Using a Modified Pressure Equilibration Test is Predictive of Good Postoperative Hearing and Middle Ear Aeration in Type 1 Tympanoplasty Patients

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