Influence of middle ear mucosal condition on post-tympanoplasty audiologic outcome

Song, Chan Il; Hong, Hye Ran; Yoon, Tae Hyun

doi:10.1007/s00405-015-3590-0

Cited by 10 publications

(4 citation statements)

References 14 publications

(14 reference statements)

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“…Since transmucosal gas exchange is caused by a localized pressure gradient between the middle ear cavity and the mucosal capillaries, this mucosal exchange can be impaired by inflammatory changes in the middle ear mucosa and mastoid process, resulting in hearing loss. The condition of the middle ear mucosa around the opening of the Eustachian tube is critical for maintaining gas exchange in the middle ear cavity, and edema and inflammatory granulation tissue changes in the middle ear mucosa may obstruct the opening of the Eustachian tube, which is detrimental to the maintenance of the pressure gradient in the middle ear [11]. During otitis media, the middle ear mucosa has the unique ability to grow and proliferate to several times its original thickness, forming highly structured, pseudocomplex, columnar epithelial complexes.…”

Section: Middle Ear Mucosamentioning

confidence: 99%

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Expression and Clinical Significance of Various Cytokines in Otitis Media

He,

Zhu,

Qiang

2024

IJOHNS

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The expression and clinical significance of relevant cytokines in otitis media (OM) are discussed, and the alterations to the pathological state of the otitis media mucosa are further understood through the study of cytokine transduction pathways. More and more studies have shown that relevant cell proliferation and inflammation progression pathways play a role in the development of otitis media, such as the Jun amino-terminal protein kinase (JNK) mitogen-activated protein kinase (MAPK) signaling pathway, the NF-κB signaling pathway, and the PI3K/AKT/PTEN pathway, which are involved in the proliferation of the middle ear mucosa during otitis media, which affects the mucosal cilia, motor function, Eustachian tube function, and the mucosal ciliary function. These studies provide new ideas for the treatment of otitis media and further explore the feasibility of immunotherapy in the future treatment of otitis media. In this paper, we present a review of the latest research progress on the expression of various cytokines in otitis media.

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Section: Middle Ear Mucosamentioning

confidence: 99%

“…Changes in the morphology of the middle ear mucosa indicate that the disease is in an active state. Therefore, if there is swelling or hyperplasia of the middle ear mucosa, it may mean poor ventilation in the middle ear, indicating that the disease is in an active stage [11].…”

Section: Middle Ear Mucosamentioning

confidence: 99%

Expression and Clinical Significance of Various Cytokines in Otitis Media

He,

Zhu,

Qiang

2024

IJOHNS

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“…The healthy middle ear mucosa optimizes the mobility of the tympanic membrane after surgery and maintains the normal amplification mechanism of the middle ear and hearing. 2 …”

Section: Introductionmentioning

confidence: 99%

Effect of Bioabsorbable Poly (dl-Lactide ε-Caprolactone) on Healing of Experimentally Injured Acute Traumatic Middle Ear Mucosa Damage

Ilhan¹,

Kara²,

Şahin³

et al. 2023

Int Adv Otol

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BACKGROUND: Postoperative adhesion is an important complication after middle-ear surgeries. Although many materials have been tried to prevent this complication, the use of Poly ( dl -lactide ε-caprolactone) as an anti-adhesive material after middle-ear surgery has not yet been reported. The aim of this study was to evaluate the anti-adhesive effect of poly ( dl -lactide ε-caprolactone) on the ears of rats with middle-ear mucosa damage. Methods: In our study, 14 Wistar albino rats and 28 ears in total were used. The rats were randomly divided into 4 groups. Middle ear mucosa damage was performed in all groups with a transcanal approach under otomicroscopy in sterile conditions. The effects of poly ( dl -lactide ε-caprolactone), silicone sheet, and absorbable gelatin sponge were compared histologically with the secondary healing group. In addition, hearing evaluation was performed before the procedure and on the 28th postoperative day. Results: No significant difference was observed in transient otoacoustic emission and distortion product otoacoustic emissions tests performed before and after the surgical procedure when the groups were compared. While adhesion was observed in the tympanic membrane in the absorbable gelatin sponge group, no adhesion was observed in the other groups. In the absorbable gelatin sponge group, increased fibroblastic activity, inflammation, and neovascularization were observed in the middle-ear mucosa. No significant difference was observed in silicone sheet, poly ( dl -lactide ε-caprolactone), and control groups in terms of fibroblastic activity, inflammation, and neovascularization. Conclusion: It can be concluded that absorbable poly ( dl -lactide ε-caprolactone) is nonototoxic and biocompatible with the rat's middle ear cavity by short-term evaluation.

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“…However, to accomplish this, the middle ear cavity must be aerated so that the tympanic membrane vibrates efficiently and sound can be transmitted to the cochlear via the ossicles. 8 In order for a normal middle ear cavity to form after surgery, regeneration of the middle ear mucosa, recovery of the physiological gas ventilation capacity, and prevention of tympanic membrane adhesion are essential. However, in the presence of otitis media, middle ear mucosal function is inherently damaged and complicates the creation of an effectively pneumatized cavity, because postoperative regeneration of the middle ear mucosal epithelium is delayed.…”

Section: Introductionmentioning

confidence: 99%

Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation

et al. 2017

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The recurrence of cholesteatoma after surgical treatment often occurs as a result of poor mucosal regeneration in the middle ear cavity and mastoid cavity and changes, such as granulation tissue formation, which impair gas exchange in the middle ear cavity. Conventional tympanoplasty often results in a lack of mucosal regeneration in the resected area of the mastoid cavity. In particular, mucosal regeneration in a poorly pneumatized mastoid cavity is extremely difficult. If the middle ear mucosa can be preserved or rapid postoperative regeneration of mucosa on the exposed bone surface can be achieved after middle ear surgery, the results of surgical treatment for otitis media, including cholesteatoma, can potentially be improved and the physiological function of the middle ear can be recovered. To overcome these limitations, we developed a novel treatment method combining tympanoplasty and autologous nasal mucosal epithelial cell sheet transplantation for postoperative regeneration of the middle ear mucosa. In clinical research, we endoscopically removed an approximately 10 × 10 mm2 piece of nasal mucosal tissue. Tissue-engineered autologous nasal mucosal epithelial cell sheets were fabricated by culturing the harvested cells in an aseptic environment in a good manufacturing practice-compliant cell processing facility. The cultivated cell sheets were transplanted, during tympanoplasty, onto the exposed bony surface of the attic of the tympanic and mastoid cavities where the mucosa had been lost. We performed this procedure on four patients with middle ear cholesteatoma and one patient with adhesive otitis media. All patients showed favorable postoperative course with no adverse events or complications and the patients’ hearing ability post-transplantation remained good.

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Influence of middle ear mucosal condition on post-tympanoplasty audiologic outcome

Cited by 10 publications

References 14 publications

Expression and Clinical Significance of Various Cytokines in Otitis Media

Expression and Clinical Significance of Various Cytokines in Otitis Media

Effect of Bioabsorbable Poly (dl-Lactide ε-Caprolactone) on Healing of Experimentally Injured Acute Traumatic Middle Ear Mucosa Damage

Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation

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