Effects of in ovo injection of sulfur-containing amino acids on heat shock protein 70, corticosterone hormone, antioxidant indices, and lipid profile of newly hatched broiler chicks exposed to heat stress during incubation

Elnesr, Shaaban S.; Elwan, Hamada A. M.; Xu, Qianqian; Xie, Chang; Dong, Xin; Zou, Xiaoting

doi:10.3382/ps/pey609

Cited by 64 publications

(60 citation statements)

References 45 publications

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“…Methionine is considered to play main roles in the body (Elnesr et al, 2019), such as a glutathione precursor, protein synthesis, reactive oxygen species elimination and methylation reaction of DNA (Kidd, 2004). Thus, the presence of methionine with the AF-contaminated diets reduces the harmful effects of AF on animals fed these diets.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of potassium sorbate, hydrated sodium calcium almuniosilicate and methionine enhances growth, antioxidant status and immunity in growing rabbits exposed to aflatoxin B1 in the diet

Reda

Ismail

El-Mekkawy

et al. 2019

Animal Physiology Nutrition

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| INTRODUC TI ONMycotoxins are secondary toxic metabolites of the fungi that grow on feedstuffs in the field or during their storage, and they are known to cause health problems or death if ingested by human or animals (Qazi & Fayyaz, 2006). Aflatoxins (AFs) produced by the fungi, Aspergillus flavus and Aspergillus parasiticus, are considered one of the most toxic metabolites which contaminate feed and feed ingredients all over the world. In farm animals including rabbit which represents one of the most sensitive species to AF toxicity, the consumption of diets contaminated with AFs resulted in anorexia, decreased feed intake, altered feed utilization, reduced weight gain, inhibited growth, immune suppression, increased susceptibility to different stressors and diseases and increased mortality rate, altered reproductive AbstractThe present experiment was conducted to evaluate the effect of dietary supplementation with some feed additives (potassium sorbate; Sor, hydrated sodium calcium almuniosilicate; Hsc and L-methionine; L-M) against aflatoxin B1 (AF) toxicity in rabbits. A total of 72 growing rabbits (5-week-old) were distributed into six equal groups (4 replicates with 3 rabbits each). The experimental groups are as follows:control group, AF group (supplemented with AF 0.3 mg/kg diet), AF + Sor group (AF 0.3 mg/kg diet + Sor 2 g/kg diet), AF + Hsc group (AF 0.3 mg/kg diet + Hsc 5 g/kg diet), AF + L-M group (AF 0.3 mg/kg diet + L-M 8 g/kg diet) and AF + Mix group (AF 0.3 mg/kg diet + 2 Sor + 5 Hsc + 8 L-M g/kg diet). Live body weight and weight gain at 13 weeks of age were significantly reduced by AF. Feed intake at 13 weeks of age was decreased in AF, AF + Hsc and AF + Mix compared to the control. AF, AF + Hsc and AF + Mix showed the lowest total antioxidant capacity compared to the control.The highest level of reactive oxygen species and 8-Hydroxy-2-desoxyguanosine was observed in AF group. Using of other supplements with AF increased immunoglobu-linM than AF alone. In conclusion, dietary supplementation of Sor, L-M, Hsc or their mixture was effective in reducing the adverse effects of AF on performance, antioxidant and immune status of rabbits with more better improvement obtained by Sor or L-M separately. K E Y W O R D SAFB1, antioxidant, growth, Hsc, immunity, methionine, potassium sorbate, rabbits | 197 REDA Et Al.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation of potassium sorbate, hydrated sodium calcium almuniosilicate and methionine enhances growth, antioxidant status and immunity in growing rabbits exposed to aflatoxin B1 in the diet

Reda

Ismail

El-Mekkawy

et al. 2019

Animal Physiology Nutrition

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“…Methionine is considered as the first limiting amino acid in broilers and its deficiency may cause reduced growth performance, metabolic disorder and impaired immune system [1,2]. It plays a vital role in the production of energy through the synthesis of protein; it also enhances the broilers' livability, efficiency of feed and growth performance [3][4][5]. Also, a methyl group that is provided by sulfur-adenosyl methionine is required for many metabolic reactions such as epinephrine, carnitine, choline and creatine synthesis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Growth Performance of Broilers as Influenced by Different Levels and Sources of Methionine Plus Cysteine

Rehman

Arif

Husnain

et al. 2019

Animals

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Simple Summary: The current work evaluated the utilization of different sources of methionine either from DL-methionine (DL-Met) or L-methionine (L-Met) using different concentrations of dietary methionine plus cystine (Met + Cyst) in broiler chickens. Results showed that a better edible meat yield could be obtained by supplementing Met + Cyst at the rate of 80% of the digestible lysine.Abstract: The objective of this work was to evaluate the utilization of methionine from DL-methionine (DL-Met) and L-methionine (L-Met) with different levels of dietary methionine plus cystine (Met + Cyst) in broilers. The experimental diets were formulated by using three levels of Met + Cyst, i.e., 74%, 77% and 80% of digestible lysine. Met + Cyst was provided either from DL-Met or L-Met. A total of 450 day-old broilers were divided into six groups (five replicates of 15 birds each) in a 3 × 2 factorial arrangement under completely randomized design. Weight gain (WG), feed intake (FI) and feed conversion ratio (FCR) was determined. At the end of the experiment (35 days), two birds from each replicate were slaughtered to determine carcass characteristics and serum homocysteine. Results indicate that the combined effect of L-Met and DL-Met significantly affected (p < 0.05) the WG in the starter period and FI in the finisher period. Neither source nor level of methionine influenced (p > 0.05) the FI, WG and FCR of broilers during the starter, finisher or overall phase of growth. The interaction between sources and levels of methionine did not influence (p > 0.05) the feed intake, weight gain and FCR during the overall phase of growth. Source of methionine had no (p > 0.05) effect on carcass characteristics. Methionine levels had a significant effect (p < 0.05) on carcass weight, chest weight and thigh weight. The interaction between sources and levels of methionine had a significant (p < 0.05) effect on the liver weight. The sources of methionine had significant (p < 0.05) effects on the liver and heart weight, while methionine levels significantly influenced (p < 0.05) the liver and gizzard weight. Finally, it was concluded that if DL-Met and L-Met are included in feed at a standard level, they are equally effective as a source of methionine for broilers.

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“…The technique of delivering various substances via the in ovo route is gaining wide attention among researchers worldwide (Saeed et al, ) to benefit from useful materials (Elnesr et al, ; Elwan et al, ) or to find out the negative effects of some substances, such as glyphosate, in an early stage. Glyphosate, N‐(phosphonomethyl) glycine, use is now widespread in the agricultural production, both in industrialized and in developing countries (Benbrook, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of in ovo glyphosate injection on embryonic development, serum biochemistry, antioxidant status and histopathological changes in newly hatched chicks

Fathi

Abdelghani

Shen

et al. 2019

Animal Physiology Nutrition

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This study aimed to investigate the potential toxic effects of pure glyphosate or Roundup® on hatchability, serum biochemistry and histopathological observation of the liver and kidney of newly hatched chicks. On day six, a total of 225 fertile eggs were obtained from Huafeng breeder hens. The eggs were randomly divided into three treatments: (a) the control group injected with deionized water, (b) the glyphosate group injected 10 mg pure glyphosate/Kg egg mass and (c) the Roundup group injected 10 mg the active ingredient glyphosate in Roundup®/Kg egg. The results showed a decrease of hatchability rate in chicks treated with Roundup® (66%). In addition, no significant change was observed in body weights, yolk sac weight and relative weight organs except the liver and kidney were significantly increased with groups treated with glyphosate and Roundup® compared to the control group. The results showed that serum protein profiles were linearly significantly increased of serum phosphor, uric acid, aspirate aminotransferase, alanine transaminase and alkaline phosphatase in groups treated with Roundup®, as well as the serum concentrations of triglyceride altered after treatment with glyphosate. Furthermore, oxidative stress was observed in the treated chicks, the glyphosate and Roundup® induced changes of the content of malondialdehyde in both the liver and kidney, moreover decrease of glutathione peroxidase, total superoxide dismutase and catalase activity in the kidney tissue and serum. Additionally, changes also happened in the histomorphology of the liver and kidney tissue of the treated chicks. It can be concluded that Roundup® as a probable decrease of hatchability. Exposure to glyphosate alone or Roundup® caused liver and kidney histopathological alterations, serum parameters imbalances and oxidative stress, also induced a variety of liver and kidney biochemical alterations that might impair normal organ functioning in newly hatched chicks.

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Effects of in ovo injection of sulfur-containing amino acids on heat shock protein 70, corticosterone hormone, antioxidant indices, and lipid profile of newly hatched broiler chicks exposed to heat stress during incubation

Cited by 64 publications

References 45 publications

Dietary supplementation of potassium sorbate, hydrated sodium calcium almuniosilicate and methionine enhances growth, antioxidant status and immunity in growing rabbits exposed to aflatoxin B1 in the diet

Dietary supplementation of potassium sorbate, hydrated sodium calcium almuniosilicate and methionine enhances growth, antioxidant status and immunity in growing rabbits exposed to aflatoxin B1 in the diet

Growth Performance of Broilers as Influenced by Different Levels and Sources of Methionine Plus Cysteine

Effect of in ovo glyphosate injection on embryonic development, serum biochemistry, antioxidant status and histopathological changes in newly hatched chicks

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