Effects of iloprost on experimental ischemia and reperfusion injury in rat ovary

Karaçor, Talip; Doğan, Zümrüt; Elibol, Ebru; Bülbül, Mehmet; Nacar, Mehmet Can

doi:10.1080/10520295.2019.1703219

Cited by 12 publications

(14 citation statements)

References 35 publications

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“…reported significantly increased MDA levels. 11 Similarly and parallel to the results reported by previous studies, we observed higher MDA levels after the I/R injury in the ovarian tissue in the I/R group compared to the control group in this study. In addition, MDA levels were found lower in the NEB-treated groups parallel to the findings of previous studies providing evidence for the antioxidant effects of NEB.…”

Section: Discussionsupporting

confidence: 92%

“…10 Previous studies identified many agents with antioxidant effects, preventing oxidative stress caused by ischemia and reperfusion (I/R) injury in the ovary. 11,12 In addition, the levels of tumor necrosis factor-alpha (TNF-α) and other proinflammatory cytokines increase in reperfusion injury; suggesting that anti-inflammatory agents can be involved more effectively in the prevention of ischemic damage compared to antioxidants. From this point of view, nebivolol (NEB) can be a promising therapeutic agent as it has been displayed to have antiinflammatory and anti-apoptotic effects besides its antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, glutathione (GSH) protects the tissue against reactive oxygen species (ROS), preventing tissue damage and helping the maintenance of the balance between oxidants and antioxidants 10 . Previous studies identified many agents with antioxidant effects, preventing oxidative stress caused by ischemia and reperfusion (I/R) injury in the ovary 11,12 . In addition, the levels of tumor necrosis factor‐alpha (TNF‐α) and other proinflammatory cytokines increase in reperfusion injury; suggesting that anti‐inflammatory agents can be involved more effectively in the prevention of ischemic damage compared to antioxidants.…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

Çolak

Gürlek

Topçu

et al. 2020

J of Obstet and Gynaecol

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Aim: Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in experimental ischemic (I) and ischemic-reperfusion (I/R) injury in rat ovaries. Methods: Forty-eight adult female rats were randomly separated into six groups as group 1 (control) receiving an oral saline solution for 3 days; group 2 (I) that underwent ischemia for 3 h with the application of atraumatic vascular clips; group 3 (I/R); group 4 (I + NEB) receiving 10 mg/kg NEB by oral gavage 30 min prior to the ischemia induction; group 5 (I/R + NEB) receiving 10 mg/kg NEB, and group 6 (control + NEB) receiving oral 10 mg/kg NEB for 3 days before ischemia induction followed by consequent reperfusion. Ovarian tissue damage was scored by histopathological analysis. Ovarian tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured biochemically. Results: The levels of MDA and tumor necrosis factor-alpha (TNF-α), and TUNEL assay positivity scores increased in the I and I/R groups. GSH levels decreased in all case groups (P < 0.05). The oral administration of NEB (10 mg/kg) to the I-and I/R-groups reduced the levels of MDA and TNF-α and TUNEL assay immunopositivity scores (P < 0.05). GSH levels increased in the treatment groups. Conclusion: The current experimental ovarian torsion study suggests a protective role for NEB against I and I/R injury in rat ovaries. NEB may be a novel agent for decreasing ovarian I/R injury.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

Çolak

Gürlek

Topçu

et al. 2020

J of Obstet and Gynaecol

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“…Numerous therapeutic agents showing antioxidant actions have been studied for protective effects against ovarian ischemia reperfusion injury rat models [29][30][31][32]. Melatonin, an endogenous indolamine related to circadian rhythms, has proven itself as an essential agent against toxic free radicals and provides a strong defense against ischemia reperfusion injury [33,34].…”

Section: Discussionmentioning

confidence: 99%

Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite

Kalyoncu¹,

Yılmaz²,

Demır³

et al. 2020

Turk J Med Sci

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Background/aim: To evaluate the protective effect of melatonin on ovarian ischemia reperfusion injury in a rat model. Materials and methods: Forty-eight rats were separated equally into 6 groups. Group 1: sham; Group 2: surgical control with 3-h bilateral ovarian torsion and detorsion; Group 3: intraperitoneal 5% ethanol (1 mL) just after detorsion (as melatonin was dissolved in ethanol); Group 4: 10 mg/kg intraperitoneal melatonin 30 min before 3-h torsion; Group 5:10 mg/kg intraperitoneal melatonin just after detorsion; Group 6:10 mg/kg intraperitoneal melatonin 30 min before torsion and just after detorsion. Both ovaries and blood samples were obtained 7 days after detorsion for histopathological and biochemical analysis.Results: In Group 1, serum levels of total oxidant status (TOS) (μmol H2O2 equivalent/g wet tissue)were significantly lower than in Group2 (P = 0.0023), while tissue TOS levels were lower than in Group 3 (P = 0.0030). Similarly, serum and tissue levels of peroxynitrite in Group 6were significantly lower than those ofGroup 2 (P = 0.0023 and P = 0.040, respectively). Moreover, serum oxidative stress index (OSI) (arbitrary unit) levels were significantly increased in Group 2 when compared to groups 1 and 6 (P = 0.0023 and P= 0.0016, respectively) and in Group 3 with respect to groups 1, 4, 5, and 6 (P = 0.0023, P = 0.0026, P = 0.0008, and P = 0.0011, respectively). Furthermore, there was a significant decrease in histopathological scores including follicular degeneration, vascular congestion, hemorrhage, and inflammation in the melatonin and sham groups in comparison with control groups. Additionally, primordial follicle count was significantly higher in Group 6 than in Group 2 (P = 0.0002).Conclusion: Melatonin attenuates ischemia reperfusion damage in a rat torsion/detorsion model by improving histopathological and biochemical findings including OSI and peroxynitrite.

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“…However, reperfusion after detorsion of the ovary can be also hazardous because of neutrophil infiltration and excessive production of reactive oxygen species (ROS), called ischemia–reperfusion injury 3 . Pharmacologic conditioning with different drugs, having antioxidant and anti‐inflammatory properties, has been investigated to test their preventive effect on ischemia–reperfusion injury 4–8 …”

Section: Introductionmentioning

confidence: 99%

Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress

Kalyoncu

Yılmaz

Demır

et al. 2020

J of Obstet and Gynaecol

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Aim: To investigate the protective effect of octreotide and lanreotide on ovarian damage in experimental ovarian ischemia-reperfusion injury. Methods: Fifty-six rats were separated into seven groups; group 1: sham group, group 2: surgical control group with 3-h torsion and detorsion, group 3: 0.02 mg/kg s.c. octreotide 30 min before 3-h torsion, group 4; octreotide just after detorsion for 7 days, group 5: octreotide 30 min before torsion and just after detorsion for 7 days, group 6: single time 20 mg/kg s.c. lanreotide before torsion, group 7: single time lanreotide just after detorsion. Results: All histopathological scores except congestion were significantly lower in group 1 than other groups. In addition, hemorrhage (group 2 vs 4: P < 0.05), degeneration (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.01 and group 2 vs 6: P < 0.05) and total damage score (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.05, group 2 vs 6: P < 0.05 and group 2 vs 7: P < 0.05) were significantly lower than other groups. Moreover, ovarian tissue total oxidant status and oxidative stress index levels were significantly decreased in groups 5 (both P < 0.05) and 7 (both P < 0.05) when compared to group 2. Furthermore, tissue levels of peroxynitrite were significantly higher in group 2 than groups 1, 3 and 5 (all P < 0.05). Conclusions: Octreotide and lanreotide have a protective role against ischemia-reperfusion damage in rat torsion detorsion model by improving histopathological and biochemical findings including tissue levels of total oxidant status, oxidative stress index and peroxynitrite.

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Effects of iloprost on experimental ischemia and reperfusion injury in rat ovary

Cited by 12 publications

References 35 publications

Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite

Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress

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