Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress

Abstract

Aim: To investigate the protective effect of octreotide and lanreotide on ovarian damage in experimental ovarian ischemia-reperfusion injury. Methods: Fifty-six rats were separated into seven groups; group 1: sham group, group 2: surgical control group with 3-h torsion and detorsion, group 3: 0.02 mg/kg s.c. octreotide 30 min before 3-h torsion, group 4; octreotide just after detorsion for 7 days, group 5: octreotide 30 min before torsion and just after detorsion for 7 days, group 6: single time 20 mg/kg s.c. lanreotide before torsion, group 7: single time lanreotide just after detorsion. Results: All histopathological scores except congestion were significantly lower in group 1 than other groups. In addition, hemorrhage (group 2 vs 4: P < 0.05), degeneration (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.01 and group 2 vs 6: P < 0.05) and total damage score (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.05, group 2 vs 6: P < 0.05 and group 2 vs 7: P < 0.05) were significantly lower than other groups. Moreover, ovarian tissue total oxidant status and oxidative stress index levels were significantly decreased in groups 5 (both P < 0.05) and 7 (both P < 0.05) when compared to group 2. Furthermore, tissue levels of peroxynitrite were significantly higher in group 2 than groups 1, 3 and 5 (all P < 0.05). Conclusions: Octreotide and lanreotide have a protective role against ischemia-reperfusion damage in rat torsion detorsion model by improving histopathological and biochemical findings including tissue levels of total oxidant status, oxidative stress index and peroxynitrite.

Sildenafil as a Salvage Treatment for Ovarian Torsion: A Rat Model

“…From a histopathological perspective, the use of these agents also led to a decrease in follicular degeneration, vascular congestion, hemorrhage, and inflammation. Similar studies with different medical agents, such as metformin, which show the same effects, have also been presented in the literature (23)(24)(25).…”

Effect of octreotide on oxidative stress in the erythrocyte and kidney tissue in adriamycin-induced experimental nephrotic syndrome model

“…Because of the involvement of oxidative stress in kidney fibrosis, therapies targeting oxidative stress are promising 27 . As far as we can tell from the literature, OCT, which has been tried in various diseases and shown to influence ROS 22 , 37 , has never been tried in NS.…”

Efeito do octreotide no estresse oxidativo em eritrócitos e no tecido renal no modelo de síndrome nefrótica experimental induzida por adriamicina

“…Devido ao envolvimento do estresse oxidativo na fibrose renal, as terapias que visam o estresse oxidativo são promissoras 27 . Até onde sabemos pela literatura, o OCT, que foi testado em diversas doenças e demonstrou influenciar as EROs 22,37 , nunca foi testado na SN.…”