Effects of<i>Teucrium polium</i>spp.<i>capitatum</i>flavonoids on the lipid and carbohydrate metabolism in rats

Stefkov, Gjoshe; Kulevanova, S.; Miova, Biljana; Dinevska-Ќovkarovska, Suzana; Mølgaard, Per; Jäger, Anna K.; Josefsen, Knud

doi:10.3109/13880209.2011.552187

Cited by 28 publications

(31 citation statements)

References 36 publications

(43 reference statements)

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“…Chemical composition of the essential oils of T. capitatum has been investigated (Antunes et al, 2004;Cozzani et al, 2005;Djabou et al, 2012;Menichini et al, 2009;Miti c et al, 2012), showing antiproliferative activity during in vitro cytotoxic assay on human cancer cell lines (Menichini et al, 2009) and antioxidant and anti-inflammatory activities in vitro (Kerbouche et al, 2015). Extracts from aerial parts of this plant were also found to contain flavonoids with insulinotropic and antihyperglycemic effects on the lipid and carbohydrate metabolism in rats (Stefkov et al, 2011). Teucrium polium has also been traditionally used for different pathological conditions such as gastrointestinal disorders, inflammations, diabetes, and rheumatism, while various compounds have been isolated from various parts of it, mainly terpenoids and flavonoids, which possess a broad spectrum of pharmacological properties including antioxidant, anticancer, anti-inflammatory, hypoglycemic, hepatoprotective, hypolipidemic, antibacterial, and antifungal (Bahramikia and Yazdanparast, 2012).…”

Section: )mentioning

confidence: 99%

In Vitro Seed and Clonal Propagation of the Mediterranean Aromatic and Medicinal Plant Teucrium capitatum

Papafotiou¹,

Martini²

2016

horts

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The effect of various pretreatments, culture conditions, and storage time on in vitro germination of seeds, as well as the effect of explant origin and plant growth regulators on in vitro propagation of Teucrium capitatum L. (Teucrium polium sp. capitatum Arcang., Lamiaceae) were examined. Seeds, collected from native plants and stored at room temperature for 3, 7, and 12 months, were cultured for germination in vitro in petri dishes with solid half-strength (½) Murashige and Skoog (1962) growth medium (MS) at 5, 10, 15, 20, 25, and 30 °C, and 16 hours light or continuous darkness. Pretreatments, such as cold stratification, scarification with sandpaper, dipping in concentrated sulfuric acid (H2SO4 > 95%), or dipping in boiling water were tested. Seeds without any pretreatment germinated at lower than 10%. Dipping in concentrated H2SO4 for 15 or 20 minutes was the most effective pretreatment, but still seed germination achieved was low (36%). Seeds preserved their germination capacity for at least 1 year, and germinated satisfactorily at a wide temperature range, from 15 to 25 °C (optimum), while photoperiod did not affect seed germination. Explants excised from in vitro-grown seedlings were established in vitro on MS medium with 1.0 mg·L−1 6-benzyladenine (BA) at much higher rates (≈90%) compared with those collected from plants grown from cuttings in a greenhouse (25%), while explants collected from adult wild plants failed to do so. Explants from seedlings showed strong variability in their response; those excised from branched seedlings formed shoots at significantly higher percentage (90%) at the establishment stage (cultured on MS medium with 0.5–2.0 mg·L−1 BA) than explants excised from unbranched seedlings (36% to 43%), while during subcultures on MS medium with 1.0 mg·L−1 BA, explants from branched seedlings also showed higher multiplication rates than those from unbranched ones. BA at 0.5–2.0 mg·L−1 induced shoot multiplication during both establishment and multiplication stages (7–8 and 14–15 shoots per explant, respectively), while kinetin and 6-γ-γ-(dimethylallylamino)-purine (2iP) were less effective than BA, and zeatin the least appropriate. Microshoot rooting was enhanced by 1-week culture on (½) MS medium with 1.0–4.0 mg·L−1 indole-3-butyric acid (IBA), followed by transfer to auxin-free, (½) MS medium (93% to 98%, 7–8 roots per microshoot), compared with culture on the same medium continuously for 5 weeks (69% to 80%, 5–6 roots per microshoot) or at lower IBA concentrations. Plantlets were acclimatized to ex vitro conditions at 98% on a peat–perlite (1:1, v/v) mixture.

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Section: )mentioning

confidence: 99%

In Vitro Seed and Clonal Propagation of the Mediterranean Aromatic and Medicinal Plant Teucrium capitatum

Papafotiou¹,

Martini²

2016

horts

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“…Infusion of the leaves and flowers is consumed as a appetite stimulating beverage. Some biological and therapeutic effects have been reported for the plant such as anti-oxidant (Kadifkova Panovska et al, 2005;Ardestani et al, 2008;Esmaeili et al, 2009), anti-inflammatory (Tariq et al, 1989;Capasso et al, 1983), anti-nociceptive (Baluchnejadmojarad et al, 2005;Abdollahi et al, 2003), anti-pyretic (Autore et al, 1984), antimicrobial (Autore et al, 1984;Zerroug et al, 2011), hypolipidemic (Rasekh et al, 2001, Esmaeili andYazdanparast, 2004;Stefkov et al, 2011), hepatoprotective (Panovska et al, 2007), cytotoxic and apoptotic effects (Rajabalian et al, 2008). It is also found that protects against ethanolinduced gastric mucosal damage (Mashreghi and Niknia, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…bull., 58 (1, 2) 39 -44 (2012) Gjoshe Stefkov, Marija Karapandzova, Marina Stefova, Vassya Bankova, Svetlana Kulevanova highly methylated aglycons are identified until now (Verykokidou-Vitsaropoulou and Vajias, 1986;Rizk et al, 1986;Kawashty et al, 1999;Harborne et al, 1986;Sharififar et al, 2009). Recently was published that freeze-dried extract of T. polium that contain flavonoids posses insulinotropic and antihyperglycemic effects (Stefkov et al, 2011). It is known that freeze-draying or lyophilisation or cryodesication is dehydratation process typically used to preserve a perishable material or make the material more convenient for transport.…”

Section: Introductionmentioning

confidence: 99%

HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L. (Lamiaceae)

Stefkov¹,

Karapandzova²,

Стефова³

et al. 2012

Maced. Pharm. Bull.

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Тhe aim of the study was identification and determination of the content of flavonoids in dry extracts of Teucrium polium, collected from Republic of Macedonia. Two different drying procedures were used, freeze and spray draying. In freeze-dried (FDE) and spray-dried (SDE) extracts of aerial parts of T. polium five flavone aglycones (luteolin, apigenin, cirsiliol, cirsimaritin and cirsilineol) were identified by HPLC method, on the base of retention times and UV spectral data of the components of the extracts in comparison to the authentic samples of flavonoids. Additionally, seven glycosides of apigenin and luteolin were tentatively identified. No significant differences in the composition nor in the content of identified flavonoids were found between both extracts. The content of total flavonoids determined by UV-spectrophotometry with AlCl3 was 72.8 ± 0.62 mg Lut/g and 73.34 ± 0.53 mg Lut/g in FDE and SDE extract of T. polium, respectively.

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“…Infusion of the leaves and flowers is consumed as a appetite stimulating beverage. Some biological and therapeutic effects have been reported for the plant such as anti-oxidant (Kadifkova Panovska et al, 2005;Ardestani et al, 2008;Esmaeili et al, 2009), anti-inflammatory (Tariq et al, 1989;Capasso et al, 1983), anti-nociceptive (Baluchnejadmojarad et al, 2005;Abdollahi et al, 2003), anti-pyretic (Autore et al, 1984), antimicrobial (Autore et al, 1984;Zerroug et al, 2011), hypolipidemic (Rasekh et al, 2001, Esmaeili andYazdanparast, 2004;Stefkov et al, 2011), hepatoprotective (Panovska et al, 2007, cytotoxic and apoptotic effects (Rajabalian et al, 2008). It is also found that protects against ethanolinduced gastric mucosal damage (Mashreghi and Niknia, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Mainly, flavone glycosides with highly methylated aglycons are identified until now (Verykokidou-Vitsaropoulou and Vajias, 1986;Rizk et al, 1986;Kawashty et al, 1999;Harborne et al, 1986;Sharififar et al, 2009). Recently was published that freeze-dried extract of T. polium that contain flavonoids posses insulinotropic and antihyperglycemic effects (Stefkov et al, 2011). It is known that freeze-draying or lyophilisation or cryodesication is dehydratation process typically used to preserve a perishable material or make the material more convenient for transport.…”

Section: Introductionmentioning

confidence: 99%

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Maced. Pharm. Bull.

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Periodontitis is a chronic inflammatory process which affects the tooth-supporting structures of the teeth. The disease is initiated by subgingival periopathogenic bacteria in susceptible periodontal sites. The host immune response towards periodontal pathogens helps to sustain periodontal disease and eventual alveolar bone loss. Although scaling and root planing is the standard treatment modality for periodontitis, it suffers from several drawbacks such as the inability to reach the base of deep pockets and doesn't arrest migration of periodontal pathogens from other sites in the oral cavity. In order to overcome the limitations of scaling and root planning, adjunctive chemotherapeutics and host modulatory agents to the treatment are used. These therapeutic agents show substantial beneficial effects when compared to scaling and root planning alone. This review will cover an update on chemotherapeutic and past and future host immune modulatory agents used adjunctively to treat and manage periodontal diseases.

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Effects ofTeucrium poliumspp.capitatumflavonoids on the lipid and carbohydrate metabolism in rats

Abstract: The results demonstrate that examined plant extracts contain flavonoids with insulinotropic and antihyperglycemic effects.

Cited by 28 publications

References 36 publications

In Vitro Seed and Clonal Propagation of the Mediterranean Aromatic and Medicinal Plant Teucrium capitatum

In Vitro Seed and Clonal Propagation of the Mediterranean Aromatic and Medicinal Plant Teucrium capitatum

HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L. (Lamiaceae)

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