Effects of hypothalamic hormones (GRF, TRH, Somatostatin) and insulin-like growth factor I on growth hormone secretion from prepubertal male lamb pituitary cultures

Goodyer, Cynthia G.; Charrier, J.; Dulor, J.-P.; Barenton, Bruno; Garandel, Véronique; Fraysse, A.

doi:10.1051/rnd:19870403

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…In all of the species cited above, including lambs, the maximal effective dose of GRF is 0.5-1 gg/kg. Similarities among species concerning GRF dose-response effect have been confirmed in pituitary cell cultures (Law et al, 1984 ;Blanchard et al, 1987 ;Brazeau et al, 1982).…”

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confidence: 60%

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Characteristics of growth hormone response to the administration of growth hormone-releasing hormone (GRF) in the lamb

Barenton¹,

Duclos²,

Diaz³

et al. 1987

Reprod. Nutr. Dévelop.

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confidence: 60%

“…In sheep, hGRF has been shown to stimulate GH secretion in the fetus (Ohmura et al, 1984), as well as in cultured pituitary cells (Law et al, 1984 ;Blanchard et al, 1987). Therefore hGRF appears to be an appropriate form of the peptide to use to investigate dynamic changes of GH release in sheep.…”

mentioning

confidence: 99%

Characteristics of growth hormone response to the administration of growth hormone-releasing hormone (GRF) in the lamb

Barenton¹,

Duclos²,

Diaz³

et al. 1987

Reprod. Nutr. Dévelop.

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“…The GRF-induced GH secretion was also decreased by IGF-I, but this reduction was less than that seen for basal secretion. In rodents (Berelowitz et al l98l) and sheep (Blanchard et al 1987;Silverman et al 1989), IGF-I caused a significant reduction in GRF-induced GH secretion, indicating that IGF-I may control GH secretion by modulating GRF effects at the pituitary level. In contrast with our results, Blanchard et al (1988) Glenn (1996), who showed that IGF-I did not suppress basal or GRFstimulated GH release in bovine pituitarv cells.…”

Section: Resultsmentioning

confidence: 99%

“…Pituitary Gi{ secre-and hypothalamic (Berelowitz 1981;Brazeau et al' 1982) iion is under the control of nvo hypothalamic faciors, n'amely, levels in rats. Such results at the pituitary lgvel yele^l-1o found GRF (Guillemin et al 1982f 'and somatostarin (SRIF; with in vitro studies in lambs (Blanchard et al 1987) and in Brazeau et al 1973). The GRF-induced GH response in fetal vivo studies in rats (Thnnenbaum et al' 1983).…”

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confidence: 89%

Negative feedback of insulin-like growth factor-I on growth hormone secretion by porcine pituitary cells

Farmer¹,

Lapierre²

1995

Can. J. Anim. Sci.

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300 or 400 ng mL-r of IGF-I. Half of the wells from each concentration of IGF-I were then incubated for an additional 3 h with concentrationi of IGF-I similar to those in the previous incubation, while the other half also had GRF added to the testing media to reach a final concentration of l0-E M. Culture media were then collected from all the wells, were frozen, and later assayed for GH. Irrespective of whether GRF was present, IGF-I decreased pituitary secretion of GH (P < 0.001). A significant negative response to IGF-I was already present at the dose ot 5U ng mL ip < O.OOOfl. However, the extent of the GH ..tponJ. to IGF-I seen in pigs of various ages differed depending on whether dRF *u. present. The present results therefore establish that IGF-I does exert a negative f99dba9t on pituitary GH secretion in swine and that the agi-related changes in this feedback are dependent on the presence of C!f. In swine, it appears that high circulating concentratiJns of GH in latJ-gestation fetuses are not a result of a lesser sensitivity of the somatotroph to the inhibitory actions of IGF-I.

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“…TRH seems to be equipotent to GHRH 109 in the case of chickens 110 but not in fowl 110–113 . In mammals, TRH has been demonstrated to stimulate GH release in cattle 114 and in sheep 73,115,116 . In humans, the ability of TRH to induce GH release is maintained in tumor somatotropinoma cells, while this effect is less evident in normal subjects, thereby suggesting that, as for PACAP, TRH has lost, at least in part, its capacity to act as a primary stimulus for the somatotrope axis 117–120 …”

Section: Regulation Of Gh Secretionmentioning

confidence: 99%

Understanding the Multifactorial Control of Growth Hormone Release by Somatotropes

Gahete

Durán-Prado

Luque

et al. 2009

Annals of the New York Academy of Sciences

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Control of postnatal growth is the main, but not the only, role for growth hormone (GH) as this hormone also contributes to regulating metabolism, reproduction, immunity, development, and osmoregulation in different species. Likely owing to this variety of group-specific functions, GH production is differentially regulated across vertebrates, with an apparent evolutionary trend to simplification, especially in the number of stimulatory factors governing substantially GH release. Thus, teleosts exhibit a multifactorial regulation of GH secretion, with a number of factors, from the newly discovered fish GH-releasing hormone (GHRH) to pituitary adenylate cyclase-activating peptide (PACAP) but also gonadotropin-releasing hormone, dopamine, corticotropin-releasing hormone, and somatostatin(s) directly controlling somatotropes. In amphibians and reptiles, GH secretion is primarily stimulated by the major hypothalamic peptides GHRH and PACAP and inhibited by somatostatin(s), while other factors (ghrelin, thyrotropin-releasing hormone) also influence GH release. Finally, in birds and mammals, primary control of GH secretion is exerted by a dual interplay between GHRH and somatostatin. In addition, somatotrope function is modulated by additional hypothalamic and peripheral factors (e.g., ghrelin, leptin, insulin-like growth factor-I), which together enable a balanced integration of feedback signals related to processes in which GH plays a relevant regulatory role, such as metabolic and energy status, reproductive, and immune function. Interestingly, in contrast to the high number of stimulatory factors impinging upon somatotropes, somatostatin(s) stand(s) as the main primary inhibitory regulator(s) for this cell type.

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Effects of hypothalamic hormones (GRF, TRH, Somatostatin) and insulin-like growth factor I on growth hormone secretion from prepubertal male lamb pituitary cultures

Abstract: Introduction.

Cited by 10 publications

References 9 publications

Characteristics of growth hormone response to the administration of growth hormone-releasing hormone (GRF) in the lamb

Characteristics of growth hormone response to the administration of growth hormone-releasing hormone (GRF) in the lamb

Negative feedback of insulin-like growth factor-I on growth hormone secretion by porcine pituitary cells

Understanding the Multifactorial Control of Growth Hormone Release by Somatotropes

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