2009
DOI: 10.1111/j.1749-6632.2008.03660.x
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Understanding the Multifactorial Control of Growth Hormone Release by Somatotropes

Abstract: Control of postnatal growth is the main, but not the only, role for growth hormone (GH) as this hormone also contributes to regulating metabolism, reproduction, immunity, development, and osmoregulation in different species. Likely owing to this variety of group-specific functions, GH production is differentially regulated across vertebrates, with an apparent evolutionary trend to simplification, especially in the number of stimulatory factors governing substantially GH release. Thus, teleosts exhibit a multif… Show more

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Cited by 93 publications
(77 citation statements)
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References 220 publications
(243 reference statements)
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“…Growth hormone (GH) secretion is regulated by two major hypothalamic neuropeptides, GH-releasing hormone (GHRH) and somatostatin 14 (SS14) (Tannenbaum et al 2003, Gahete et al 2009). In teleosts, however, a unique component of the multifactorial control of somatotropes is gonadotropin-releasing hormone (GnRH), which directly stimulates GH secretion and mRNA expression chicken (c) GnRHII (or GnRH2) and salmon (s) GnRH (or GnRH3) (Yu et al 1988).…”
Section: Introductionmentioning
confidence: 99%
“…Growth hormone (GH) secretion is regulated by two major hypothalamic neuropeptides, GH-releasing hormone (GHRH) and somatostatin 14 (SS14) (Tannenbaum et al 2003, Gahete et al 2009). In teleosts, however, a unique component of the multifactorial control of somatotropes is gonadotropin-releasing hormone (GnRH), which directly stimulates GH secretion and mRNA expression chicken (c) GnRHII (or GnRH2) and salmon (s) GnRH (or GnRH3) (Yu et al 1988).…”
Section: Introductionmentioning
confidence: 99%
“…O hormônio do crescimento é secretado em pulsos e o padrão de secreção pode variar dependendo do sexo, espécie e fotoperíodo (GAHETE et al, 2009). Apesar de a pulsatilidade ser controlada pelo hipotálamo, foi observado também cultura de somatotrófos apresentando secreção de GH púlsatil (HASSAN;MERKEL, 1994).…”
Section: Discussionunclassified
“…Hypothalamic control of GH secretion in mammals has long been considered as a classic paradigm of the "dual control" system with growth hormone-releasing hormone (GHRH) and somatotropin release-inhibiting factor (SRIF, or somatostatin) (Goldenberg and Barkan, 2007). However, teleosts exhibit a more complex multifactorial hypothalamic regulation of GH secretion than in mammalian vertebrates because of the unique organization of the hypothalamo-pituitary axis (Gahete et al, 2009). Consequently, a number of neuroendocrine regulation factors are involved in GH release of the pituitary gland, not only from GHRH to pituitary adenylate cyclase activating peptide (PACAP), but also SRIF, gonadotropin-releasing hormone (GnRH) etc.…”
Section: Introductionmentioning
confidence: 99%