Effects of hyperthermia with dextran magnetic fluid on the growth of grafted H22 tumor in mice

Yu, Zhenhai; Xie, Hong; Gu, Hongchen

doi:10.1080/02656730802363643

Cited by 14 publications

(7 citation statements)

References 17 publications

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“…The direct injection method consists of injecting directly the magnetic uid into the tumour. The intratumoural injection is the simplest way to administer the NPs, and is therefore the most used in in vivo studies 70,71 and has even already been used in clinical trials of MFH. 39,72 The main advantage of this technique is the ease of achieving a high and localised concentration of MNPs in the tumour.…”

Section: Nanoparticle Delivery To the Tumour Sitementioning

confidence: 99%

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

2014

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Magnetic nanoparticles have been widely investigated for their great potential as mediators of heat for localised hyperthermia therapy. Nanocarriers have also attracted increasing attention due to the possibility of delivering drugs at specific locations, therefore limiting systematic effects. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia was noticed more than thirty years ago. However, combining magnetic nanoparticles with molecules of drugs in the same nanoformulation has only recently emerged as a promising tool for the application of hyperthermia with combined chemotherapy in the treatment of cancer. The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies. The principle of magnetic fluid hyperthermia is also presented.

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Section: Nanoparticle Delivery To the Tumour Sitementioning

confidence: 99%

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

2014

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“…13 On direct injection of SPIONs, hyperthermic temperatures were achieved in mouse models of breast cancer, leading to improved tumor control. 14,15 SPIONs were well tolerated in human glioblastoma multiforme patients [16][17][18] and thermotherapeutic temperatures were achieved, leading to local tumor control and a doubled survival rate in patients. 17,19 MFH also induced a 4.5-fold increase in survival time in a rat model of malignant glioma.…”

Section: Introductionmentioning

confidence: 99%

Application of magnetic field hyperthermia and superparamagnetic iron oxide nanoparticles to HIV-1-specific T-cell cytotoxicity

Williams¹,

Southern²,

Lissina

et al. 2013

IJN

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Abstract:The latent HIV-1 reservoir remains the major barrier to HIV-1 eradication. Although successful at limiting HIV replication, highly active antiretroviral therapy is unable to cure HIV infection, thus novel therapeutic strategies are needed to eliminate the virus. Magnetic field hyperthermia (MFH) generates thermoablative cytotoxic temperatures in target-cell populations, and has delivered promising outcomes in animal models, as well as in several cancer clinical trials. MFH has been proposed as a strategy to improve the killing of HIV-infected cells and for targeting the HIV latent reservoirs. We wished to determine whether MFH could be used to enhance cytotoxic T-lymphocyte (CTL) targeting of HIV-infected cells in a proof-of-concept study. Here, for the first time, we apply MFH to an infectious disease (HIV-1) using the superparamagnetic iron oxide nanoparticle FeraSpin R. We attempt to improve the cytotoxic potential of T-cell receptor-transfected HIV-specific CTLs using thermotherapy, and assess superparamagnetic iron oxide nanoparticle toxicity, uptake, and effect on cell function using more sensitive methods than previously described. FeraSpin R exhibited only limited toxicity, demonstrated efficient uptake and cell-surface attachment, and only modestly impacted T-cell function. In contrast to the cancer models, insufficient MFH was generated to enhance CTL killing of HIV-infected cells. MFH remains an exciting new technology in the field of cancer therapeutics, which, as technology improves, may have significant potential to enhance CTL function and act as an adjunctive therapy in the eradication of latently infected HIV-positive cells.

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“…[14][15][16][17] In addition, the use of magnetic field stimulation to induce tumour cell hyperthermia following intravenous administration of MNPs has been shown to be beneficial in controlling tumour growth. [18][19][20][21] Recently, we tested the in vitro functionality of fludeoxyglucose-conjugated magnetic nanoparticles (FDG-MNPs) with the aim of targeting MCF-7 cancer cells in vitro by magnetic field stimulation. As cancer cells are characterised by increased glycolysis and elevated lactate production, 22 23 a phenomenon known as the Warburg effect, 24 their higher metabolic status results in preferential uptake of FDG-MNPs over non-cancerous cells.…”

Section: Introductionmentioning

confidence: 99%

Tissue Morphology and Gene Expression Characterisation of Transplantable Adenocarcinoma Bearing Mice Exposed to Fluorodeoxyglucose-Conjugated Magnetic Nanoparticles

Watkins¹,

Pearce²,

Ünak³

et al. 2018

j biomed nanotechnol

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Fluorodeoxyglucose-conjugated magnetic nanoparticles, designed to target cancer cells with high specificity when heated by an alternating magnetic field, could provide a low-cost, non-toxic treatment for cancer. However, it is essential that the in vivo impacts of such technologies on both tumour and healthy tissues are characterised fully. Profiling tissue gene expression by semi-quantitative reverse transcriptase real-time PCR can provide a sensitive measurement of tissue response to treatment. However, the accuracy of such analyses is dependent on the selection of stable reference genes. In this study, we determined the impact of fluorodeoxyglucose-conjugated magnetic nanoparticles on tumour and nontumour tissue gene expression and morphology in MAC16 adenocarcinoma established male NMRI mice. Mice received an injection of 8 mg/kg body weight fluorodeoxyglucose-conjugated magnetic nanoparticles either intravenously in to the tail vein, directly into the tumour or subcutaneously directly overlying the tumour. Tissues from mice were sampled between 70 minutes and 12 hours post injection. Using the bioinformatic geNorm tool, we established the stability of six candidate reference genes (Hprt, Pgk1, Ppib, Sdha, Tbp and Tuba); we observed Pgk1 and Ppib to be the most stable. We then characterised the expression profiles of several apoptosis genes of interest in our adenocarcinoma samples, observing differential expression in response to mode of administration and exposure duration. Using histological assessment and fluorescent TUNNEL staining, we observed no detrimental impact on either tumour or non-tumour tissue morphology or levels of apoptosis. These observations define the underlying efficacy of fluorodeoxyglucose-conjugated magnetic nanoparticles on tumour and non-tumour tissue morphology and gene expression, setting the basis for future studies.

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Effects of hyperthermia with dextran magnetic fluid on the growth of grafted H22 tumor in mice

Abstract: Single time magnetic fluid hyperthermia significantly inhibited growth of grafted H22 tumor in mice, which mainly resulted from inducing necrosis while not inhibiting VEGF expression or inducing apoptosis.

Cited by 14 publications

References 17 publications

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Application of magnetic field hyperthermia and superparamagnetic iron oxide nanoparticles to HIV-1-specific T-cell cytotoxicity

Tissue Morphology and Gene Expression Characterisation of Transplantable Adenocarcinoma Bearing Mice Exposed to Fluorodeoxyglucose-Conjugated Magnetic Nanoparticles

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