Application of magnetic field hyperthermia and superparamagnetic iron oxide nanoparticles to HIV-1-specific T-cell cytotoxicity

Williams, James P.; Southern, Paul; Lissina, Anna; Christian, Helen; Sewell, A.K.; Phillips, Rodney E.; Pankhurst, Quentin A.; Frater, John

doi:10.2147/ijn.s44013

Cited by 38 publications

(20 citation statements)

References 61 publications

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“…First, the CD4 count alone is unable to fully gauge immunologic health after ART (20)(21)(22). Second, CD8 cells are essential to the eradication of residual HIV-1 reservoirs after ART initiation (23)(24)(25)(26). Third, CD8 cells can be induced to enhance the efficacy of vaccination (27), as reported recently in nonhuman primate models (28,29).…”

Section: D8mentioning

confidence: 99%

Dynamics and Correlates of CD8 T-Cell Counts in Africans with Primary Human Immunodeficiency Virus Type 1 Infection

Prentice

Price

et al. 2016

J Virol

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In individuals with HIV-1 infection, depletion of CD4؉ T cells is often accompanied by a malfunction of CD8 ؉ T cells that are persistently activated and/or exhausted. While the dynamics and correlates of CD4 counts have been well documented, the same does not apply to CD8 counts. Here, we examined the CD8 counts in a cohort of 497 Africans with primary HIV-1 infection evaluated in monthly to quarterly follow-up visits for up to 3 years in the absence of antiretroviral therapy. Statistical models revealed that (i) CD8 counts were relatively steady in the 3-to 36-month period of infection and similar between men and women; (ii) neither geography nor heterogeneity in the HIV-1 set-point viral load could account for the roughly 10-fold range of CD8 counts in the cohort (P > 0.25 in all tests); and (iii) factors independently associated with relatively high CD8 counts included demographics (age < 40 years, adjusted P ‫؍‬ 0.010) and several human leukocyte antigen class I (HLA-I) alleles, including HLA-A*03:01 (P ‫؍‬ 0.013), B*15:10 (P ‫؍‬ 0.007), and B*58:02 (P < 0.001). Multiple sensitivity analyses provided supporting evidence for these novel relationships. Overall, these findings suggest that factors associated with the CD8 count have little overlap with those previously reported for other HIV-1-related outcome measures, including viral load, CD4 count, and CD4/CD8 ratio. IMPORTANCELongitudinal data from 497 HIV-1 seroconverters allowed us to systematically evaluate the dynamics and correlates of CD8 ؉ T-cell counts during untreated primary HIV-1 infection in eastern and southern Africans. Our findings suggest that individuals with certain HLA-I alleles, including A*03 (exclusively A*03:01), persistently maintain relatively high CD8 counts following HIV-1 infection, a finding which may offer an intriguing explanation for the recently reported, negative association of A*03 with HIV-1-specific, broadly neutralizing antibody responses. In future studies, attention to HLA-I genotyping data may benefit indepth understanding of both cellular and humoral immunity, as well as the intrinsic balances of these types of immunity, especially in settings where there is emerging evidence of antagonism between the two arms of adaptive immunity.

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Section: D8mentioning

confidence: 99%

Dynamics and Correlates of CD8 T-Cell Counts in Africans with Primary Human Immunodeficiency Virus Type 1 Infection

Prentice

Price

et al. 2016

J Virol

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“…In a first of kind proof-of-concept study conducted by Williams et al [45], latent reservoirs of HIV were targeted by SPIONs and thermo-ablated to enhance cytotoxic T-lymphocyte targeting of HIV-infected cells. In another novel approach [46], an anti-HIV drug (tenofovir) and a latency-breaking agent (vorinostat) were co-encapsulated using magnetically guided layer-by-layer (LbL) assembled nanocarriers for the treatment of neuroAIDS.…”

Section: 1 Studies On Hivmentioning

confidence: 99%

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Yadavalli

Shukla

2017

Nanomedicine: Nanotechnology, Biology and Medicine

151

111

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Nanotechnology is increasingly playing important roles in various fields including virology. The emerging use of metal or metal oxide nanoparticles in virus targeting formulations shows the promise of improved diagnostic or therapeutic ability of the agents while uniquely enhancing the prospects of targeted drug delivery. Although a number of nanoparticles varying in composition, size, shape, and surface properties have been approved for human use, the candidates being tested or approved for clinical diagnosis and treatment of viral infections are relatively less in number. Challenges remain in this domain due to a lack of essential knowledge regarding the in vivo comportment of nanoparticles during viral infections. This review provides a broad overview of recent advances in diagnostic, prophylactic and therapeutic applications of metal and metal oxide nanoparticles in Human Immunodeficiency Virus, Hepatitis virus, influenza virus and Herpes virus infections. Types of nanoparticles commonly used and their broad applications have been explained in this review.

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“…The metallic nature of the cores offers versatile combinations of minimal invasive therapy approaches, like photothermal ablation by exploiting the absorbance of light by the gold and magnetic hyperthermia by utilizing the superparamagnetic behavior of iron oxide [12,[25][26][27][28].…”

Section: A N U S C R I P Tmentioning

confidence: 99%

A plasma protein corona enhances the biocompatibility of Au@Fe3O4 Janus particles

et al. 2015

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Au@Fe3O4 Janus particles (JPs) are heteroparticles with discrete domains defined by different materials. Their tunable composition and morphology confer multimodal and versatile capabilities for use as contrast agents and drug carriers in future medicine. Au@Fe3O4 JPs have colloidal properties and surface characteristics leading to interactions with proteins in biological fluids. The resulting protein adsorption layer ("protein corona") critically affects their interaction with living matter. Although Au@Fe3O4 JPs displayed good biocompatibility in a standardized in vitro situation, an in-depth characterization of the protein corona is of prime importance to unravel underlying mechanisms affecting their pathophysiology and biodistribution in vitro and in vivo. Here, we comparatively analyzed the human plasma corona of Au-thiol@Fe3O4-SiO2-PEG JPs (NH2-functionalized and non-functionalized) and spherical magnetite (Fe3O4-SiO2-PEG) particles and investigated its effects on colloidal stability, biocompatibility and cellular uptake. Label-free quantitative proteomic analyses revealed that complex coronas including almost 180 different proteins were formed within only one minute. Remarkably, in contrast to spherical magnetite particles with surface NH2 groups, the Janus structure prevented aggregation and the adhesion of opsonins. This resulted in an enhanced biocompatibility of corona sheathed JPs compared to spherical magnetite particles and corona-free JPs.

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Application of magnetic field hyperthermia and superparamagnetic iron oxide nanoparticles to HIV-1-specific T-cell cytotoxicity

Cited by 38 publications

References 61 publications

Dynamics and Correlates of CD8 T-Cell Counts in Africans with Primary Human Immunodeficiency Virus Type 1 Infection

Dynamics and Correlates of CD8 T-Cell Counts in Africans with Primary Human Immunodeficiency Virus Type 1 Infection

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

A plasma protein corona enhances the biocompatibility of Au@Fe3O4 Janus particles

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