Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Abstract

Magnetic nanoparticles have been widely investigated for their great potential as mediators of heat for localised hyperthermia therapy. Nanocarriers have also attracted increasing attention due to the possibility of delivering drugs at specific locations, therefore limiting systematic effects. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia was noticed more than thirty years ago. However, combining magnetic nanoparticles with molecules of drugs in the same nanoformulation has only recently emerged as a promising tool for the application of hyperthermia with combined chemotherapy in the treatment of cancer. The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies. The principle of magnetic fluid hyperthermia is also presented.

Combined Effects of Fe3O4 Nanoparticles and Chemotherapeutic Agents on Prostate Cancer Cells In Vitro

“…In addition, the combination of hyperthermia and chemotherapy in the same MNPs-based nanotherapeutic system is relatively new. Enhancement of the effects of chemotherapy with application of concurrent hyperthermia is called thermo-chemosensitization, which is dependent on the synergistic effects of hyperthermia and chemotherapy [40]. The thermal enhancement of drug cytotoxicity is maximized at mild hyperthermia temperatures and does not require temperature as high as those used for hyperthermia therapy alone.…”

Positron Annihilation in Magnetite Nanopowders Prepared by Co-Precipitation Method

“…In case of single-domain nanoparticles, heat is generated mainly by two processes: the Neel relaxation and the Brown relaxation. The first is based on changes in orientation of the magnetic spins, and consequently magnetization within each nanoparticle, while in the Brown relaxation the MNPs can be rotated as a whole, which depends on both the hydrodynamic parameters of the particle and the surrounding medium [9]. This paper focuses on the characteristics of prepared magnetite nanoparticles by co-precipitation method.…”

“…Nanocrystallites of magnetite that reach sizes of about 10 nm exhibit superparamagnetism, then they are con- * corresponding author; e-mail: marek.wiertel@umcs.pl sidered as single domains having their magnetic moments which, under the influence of an external variable magnetic field, start to fluctuate. This particular property was used in the aforementioned hyperthermia [9]. The etymological meaning of "hyperthermia" is based on the heat generated at the site of the cancer.…”

Assessing the hyperthermic properties of magnetic heterostructures: the case of gold–iron oxide composites

“…A relevant advantage of magnetic iron oxide nanostructures is that they offer the potential to act as multifunctional biomedical tools, as they may find application in diagnosis and therapeutics, both in vivo and in vitro [1][2][3][4]. In particular, magnetic fluid hyperthermia is based on cancer treatment through the heat transferred to the surrounding media by magnetic nanoparticles exposed to an alternating (AC) field with suitable amplitude and frequency [5,6].…”