Effects of Hyperthermia on the Linear and Quadratic Parameters of the Radiation Survival Curve of Mammalian Cells: Influence of Thermotolerance

Havemann, J.; Luinenburg, Mark J.; Wondergem, J.; Hart, A. A. M.

doi:10.1080/09553008714551031

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…This model predicts exponential increase of α * and β * with temperature, which is much more pronounced for β * . These predictions are consistent with experimental results in cell cultures 58,59 , and data from human clinical trials 30,52 .…”

Section: Results and Discussion: Mathematical Model For The Outcome Osupporting

confidence: 87%

“…Based on the thermodynamics of protein denaturation, we found the transition rate of this process to increase exponentially with increasing temperature k(T) = c e b(T−T g ) (see methods section for details of the model). Such exponential behaviour with (T − T g ) has been observed in previous works, but could not be explained 43,59,60 .…”

Section: Results and Discussion: Mathematical Model For The Outcome Omentioning

confidence: 49%

“…To this end, we chose three rather dated seminal studies because, to our knowledge, they are the only ones which compile complete sets of thermal enhancement ratios, systematically obtained for several temperatures or treatment times in the HT regime. Two of these data sets were collected in course of in vitro 2D culture experiments using Chinese hamster ovary (CHO) 58 and murine mammary carcinoma (M8013) cells 59 , respectively. Another set of data comes from an animal study with C3H murine mammary carcinoma experimental tumours 60 .…”

Section: Results and Discussion: Mathematical Model For The Outcome Omentioning

confidence: 99%

“…. When HT is applied in combination with RT the parameters α and β are modulated by both the temperature T, and the application time t of heat 52,59,61,62 . As a result, the sensitivity of cells to RT is increased and the radiation dose D R+H required to produce the same surviving fraction is lower.…”

Section: Results and Discussion: Mathematical Model For The Outcome Omentioning

confidence: 99%

“…Thermal modulation of α and β : The third data set was documented in cultured M8013 murine mammary carcinoma cells 59 . In this study, the normal (non-thermotolerant) cell-line was compared with a thermotolerant modification.…”

Section: Results and Discussion: Mathematical Model For The Outcome Omentioning

confidence: 99%

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Mathematical model for the thermal enhancement of radiation response: thermodynamic approach

Mendoza

Michlíková

Berger

et al. 2021

Sci Rep

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Radiotherapy can effectively kill malignant cells, but the doses required to cure cancer patients may inflict severe collateral damage to adjacent healthy tissues. Recent technological advances in the clinical application has revitalized hyperthermia treatment (HT) as an option to improve radiotherapy (RT) outcomes. Understanding the synergistic effect of simultaneous thermoradiotherapy via mathematical modelling is essential for treatment planning. We here propose a theoretical model in which the thermal enhancement ratio (TER) relates to the cell fraction being radiosensitised by the infliction of sublethal damage through HT. Further damage finally kills the cell or abrogates its proliferative capacity in a non-reversible process. We suggest the TER to be proportional to the energy invested in the sensitisation, which is modelled as a simple rate process. Assuming protein denaturation as the main driver of HT-induced sublethal damage and considering the temperature dependence of the heat capacity of cellular proteins, the sensitisation rates were found to depend exponentially on temperature; in agreement with previous empirical observations. Our findings point towards an improved definition of thermal dose in concordance with the thermodynamics of protein denaturation. Our predictions well reproduce experimental in vitro and in vivo data, explaining the thermal modulation of cellular radioresponse for simultaneous thermoradiotherapy.

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Section: Results and Discussion: Mathematical Model For The Outcome Osupporting

confidence: 87%

Section: Results and Discussion: Mathematical Model For The Outcome Omentioning

confidence: 49%

Section: Results and Discussion: Mathematical Model For The Outcome Omentioning

confidence: 99%

Section: Results and Discussion: Mathematical Model For The Outcome Omentioning

confidence: 99%

Section: Results and Discussion: Mathematical Model For The Outcome Omentioning

confidence: 99%

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Mathematical model for the thermal enhancement of radiation response: thermodynamic approach

Mendoza

Michlíková

Berger

et al. 2021

Sci Rep

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Hyperthermia and incorporation of halogenated pyrimidines: Radiosensitization in cultured rodent and human tumor cells

Bree

Franken²,

Bakker³

et al. 1997

International Journal of Radiation Oncology*Biology*Physics

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Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 09 May 2018Int. J. Radiation Oncology Biol. Phys.. Vol. 39. No. 7. pp. 489-496. 1997 ? HT further increased radiation-induced I quadratic analyses showed that I-IT further increased the linear parameter of the LQ form&a while the quadratic parameter was not s@ifkantIy changed. Con&&on: The combination of I-IT and HPs act additively in increasing the radktse~&'ivity of rod& tumor cell lhes with varying radiosensitivities as well as of a human tamor cell Iine. In pa&cuhtr, the rat&o of the &ear parameter to the quadratic parameter, relevant for fractionation effects in radiotherapy, was increased. Q 1997 Elsevier Science Inc.

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Radio-thermo-sensitivity Induced by Gold Magnetic Nanoparticles in the Monolayer Culture of Human Prostate Carcinoma Cell Line DU145

Rajaee

Khoei

Mahdavian

et al. 2020

ACAMC

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Background and Objective: Prostate cancer is the second cause of death in men worldwide. In this study, the cytotoxic effects of PLGA polymer-coated gold Magnetic Nanoparticles (MGNPs), as a novel treatment to enhance radiation and thermal sensitivity in the presence of hyperthermia (43°C) and electron beam, on DU145 prostate cancer cells were investigated. Methods: Nanoparticles were characterized using TEM, DLS, XRD and SAED methods. MGNPs entrance into the cells was determined using Prussian blue staining and TEM. Furthermore, the cytotoxic effects of combinatorial treatment modalities were assessed by applying colony and sphere formation assay. Results: Our results revealed that the decrease of colony and sphere numbers after combinatorial treatment of hyperthermia and radiation in the presence of nanoparticles was significantly higher than the other treatment groups (P<0.05). This treatment method proved that it has the capability of eliminating most of the DU145 cells (80-100%), and increased the value of the linear parameter (α) to 4.86 times. Conclusion: According to the study, magnetic gold nanoparticles, in addition to having a high atomic number, can effectively transmit heat produced inside them to the adjacent regions under hyperthermia, which increases the effects of radio-thermosensitivity, respectively.

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Effects of Hyperthermia on the Linear and Quadratic Parameters of the Radiation Survival Curve of Mammalian Cells: Influence of Thermotolerance

Cited by 5 publications

References 8 publications

Mathematical model for the thermal enhancement of radiation response: thermodynamic approach

Mathematical model for the thermal enhancement of radiation response: thermodynamic approach

Hyperthermia and incorporation of halogenated pyrimidines: Radiosensitization in cultured rodent and human tumor cells

Radio-thermo-sensitivity Induced by Gold Magnetic Nanoparticles in the Monolayer Culture of Human Prostate Carcinoma Cell Line DU145

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