Hyperthermia and incorporation of halogenated pyrimidines: Radiosensitization in cultured rodent and human tumor cells

Abstract

Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 09 May 2018Int. J. Radiation Oncology Biol. Phys.. Vol. 39. No. 7. pp. 489-496. 1997 ? HT further increased radiation-induced I quadratic analyses showed that I-IT further increased the linear parameter of the LQ form&a while the quadratic parameter was not s@ifkantIy changed. Con&&on: The combination of I-IT and HPs act additively in increasing the radktse~&'ivity of rod& tumor cell lhes with varying radiosensitivities as well as of a human tamor cell Iine. In pa&cuhtr, the rat&o of the &ear parameter to the quadratic parameter, relevant for fractionation effects in radiotherapy, was increased. Q 1997 Elsevier Science Inc.

Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation

“…The effects of combining hyperthermia with radiation sensitization by halogenated pyrimidines on PLD were studied by Van Bree et al (1997). It has been suggested that radiation sensitization by HP might be attributed to the conversion of low LET lesions into high LET lesions through an increase in the clustering or severity of radiation-induced DNA damage.…”

Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model

“…In a number of former studies conducted by our laboratory, radiation sensitisation by a variety of agents in different types of mammalian cells has been investigated and cell survival curves have been analysed using the LQ model (5)(6)(7)(8)(9)(10)(11). Radiation enhancement could thus be assessed in separate α-and β-values and in the α/β ratio.…”

“…Incorporation of halogenated pyrimidines (HPs), chloro-, bromo-and iodo-deoxyuridine (CldUrd, BrdUrd, IdUrd) into DNA is known to sensitise cells to ionizing radiation (6,8,11,(86)(87)(88)(89)(90)(91)(92)(93). The induced radiosensitisation increases with the degree of thymidine replacement.…”

Radiosensitization with Hyperthermia and Chemotherapeutic Agents: Effects on Linear-Quadratic Parameters of Radiation Cell Survival Curves

“…Incorporation of halogenated pyrimidines (HPs), chloro-, bromo-and iodo-deoxyuridine (CldUrd, BrdUrd, IdUrd) into DNA is known to sensitise cells to ionizing radiation (Franken et al 1997ab, 1999ab;van Bree et al 1997;Iliakis et al 1999;Miller et al 1992ab). The induced radiosensitisation increases with the degree of thymidine-replacement.…”

“…An additional advantage of the LQ model is that its parameters can be discussed in terms of specific mechanisms of cell inactivation by radiation (Barendsen, 1990(Barendsen, , 1994. Linear-quadratic analyses of hyperthermia-or chemotherapy-induced radiation sensitisation have been reported for exponentially growing and plateau phase human tumour cells in culture and for different experimental rodent cell lines (Franken et al, 1997a(Franken et al, , 1997bvan Bree et al, 1997van Bree et al, , 2000Castro Kreder et al, 2004;Bergs et al, 2006. When the additional treatment results in increases of the value of the -parameter, this indicates that this treatment radiosensitizes at clinically relevant doses.…”