Effects of hydroxy citric acid on body weight and serum hepcidin level in women with non-alcoholic fatty liver disease a randomized clinical trial

The effect of hydroxy citric acid supplementation with calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in women with non-alcoholic fatty liver disease: a randomized controlled clinical trial

“…However, there is evidence occasionally demonstrating few cases of acute liver failure in women due to its hepatic toxicity. 30,56…”

“…3 As patients with NAFLD are mostly overweight or obese, one of the efficient strategies is weight loss by 10% of the initial weight over a 6–12 month period by decreasing energy intake by 500–1000 kcal day −1 as well as using effective dietary supplements such as vitamin E, microalgae, 22,23 conjugated linoleic acid, 24,25 α-lipoeic acid, 26–29 nutraceuticals in the form of plant extracts. 30…”

“…3 As patients with NAFLD are mostly overweight or obese, one of the efficient strategies is weight loss by 10% of the initial weight over a 6-12 month period by decreasing energy intake by 500-1000 kcal day −1 as well as using effective dietary supplements such as vitamin E, microalgae, 22,23 conjugated linoleic acid, 24,25 α-lipoeic acid, [26][27][28][29] nutraceuticals in the form of plant extracts. 30 Garcinia cambogia (G. cambogia), known as "Malabar tamarind" or "Garcinia", is a plant native to South East Asia. 31 Indeed, hydroxycitric acid (HCA; 30) as the main phytochemical of its fruit is used for weight loss.…”

“…No favorable effects were also found on serum liver enzymes. 30 We hypothesized that HCA supplementation can further improve the efficacy of lifestyle modifications in the management of NAFLD. Therefore, the present clinical trial was designed to examine the effects of HCA derived from G. combogia accompanied by calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in obese women with NAFLD.…”

Suplementos dietéticos comerciales para el control de sobrepeso: fuentes naturales de fácil acceso, mecanismos de acción y efectos adversos

“…No obstante, Golzar y cols. 81 y Landim y cols. 82 exploraron el efecto del HCA (8 semanas) y de G. cambogia enriquecido con glucomanano (GNN) (6 semanas) en personas que vivían con obesidad e hígado graso no alcohólico, encontrando reducción del peso corporal.…”