The effect of hydroxy citric acid supplementation with calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in women with non-alcoholic fatty liver disease: a randomized controlled clinical trial

Arefhosseini, Sara; Tutunchi, Helda; Golzar, Solmaz Nomi; Mahboob, Soltanali; Pouretedal, Zohreh; Ebrahimi-Mameghani, Mehrangiz

doi:10.1039/d1fo03685h

Cited by 13 publications

(22 citation statements)

References 65 publications

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“…The ratio of TG/HDL-C ratio was decreased as compared to the control. The inflammation factors were not reduced as such in the hydroxy citric group but it improved metabolic factors [65].…”

Section: Role Of Citrate In Fatty Liver Diseasementioning

confidence: 78%

Role of Sodium dependent SLC13 transporter and its inhibitors in various metabolic disorders

Akhtar

Khan

Kumar

et al. 2022

Preprint

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The sodium dependent SLC13 family transporters comprise of the five genes SLC13A1, SLC13A2 (NaDC1), SLC13A3 (NaDC3), SLC13A4 and SLC13A5 (NaCT). Among them the three NaDC1, NaDC3 and NaCT are sodium dependent transporters such as di-carboxylates (succinate, malate, α-ketoglutarate) and tricarboxylates (citrate). The mouse and the human NaCT structures have still not been crystallized, the information to the structures is taken from the related bacterial transporter of VcINDY. Citrate in the cytosol works as precursor for the fatty acid synthesis, cholesterol, and low-density lipoproteins. The excess citrate from the matrix is translocated to the cytosol for fatty acid synthesis through these receptors and thus controls the energy balance by downregulating the glycolysis, tricarboxylic acid (TCA), and fatty acid breakdown. These transporters play an important role in regulating various metabolic diseases including cancer, diabetes, obesity, fatty liver diseases and CNS disorders. These di and tricarboxylate transporters are emerging as new targets for metabolic disorders such as obesity and diabetes. The mutation in the function of the NaCT causes several neurological diseases including neonatal epilepsy and impaired brain development whereas mutation of the citrate present in the liver may provide positive effect. Therefore, continued efforts from the earlier work on citrate transporter are required for the development of citrate inhibitors. In this review the structure, function, and regulation of the NaCT receptors are discussed. The review also highlights citrate role in diagnosing diseases such as cancer, diabetes, fatty liver, and diabetes. The therapeutic perspective of synthetic inhibitors against NaCT receptors are succinctly summarized.

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“…The ratio of TG/HDL-C ratio was decreased as compared to the control. The inflammation factors were not reduced as such in the hydroxy citric group but it improved metabolic factors [65].…”

Section: Role Of Citrate In Fatty Liver Diseasementioning

confidence: 78%

Role of Sodium dependent SLC13 transporter and its inhibitors in various metabolic disorders

Akhtar

Khan

Kumar

et al. 2022

Preprint

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“…cambogia on metabolic, atherogenic, and inflammatory biomarkers were examined in obese women with nonalcoholic fatty liver disease. Results revealed that weight, body mass index, waist circumference, fasting blood sugar, hip circumference, triglyceride, and low-density lipoprotein cholesterol showed a decrease, concurrent with an increase in high-density lipoprotein cholesterol . Interestingly, fruit rinds of G .…”

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

“…Results revealed that weight, body mass index, waist circumference, fasting blood sugar, hip circumference, triglyceride, and low-density lipoprotein cholesterol showed a decrease, concurrent with an increase in high-density lipoprotein cholesterol. 28 Interestingly, fruit rinds of G. cambogia, G. indica, and G. atroviridis contain (2S,3S)-HCA with a potential to inhibit ATP-citrate lyase, 10 while the calyx of Hibiscus subdarif fa and H. rosa-sinensis produce (2S,3R)-HCA which suppresses intestinal α-glucosidase and pancreatic α-amylase, reducing carbohydrate metabolism. Likewise, (2S,3R)-HCA is produced by Streptomyces sp.…”

Section: ■ Introductionmentioning

confidence: 99%

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Recent Advances in Garcinia cambogia Nutraceuticals in Relation to Its Hydroxy Citric Acid Level. A Comprehensive Review of Its Bioactive Production, Formulation, and Analysis with Future Perspectives

2022

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Garcinia cambogia (Gaertn.) Desr. (known as Malabar tamarind) is a popular traditional herbal medicine and is one of the well-known folk medicines reported for the treatment of obesity and incorporated in several nutraceuticals worldwide. These effects are mediated by a myriad of bioactive compounds with most effects attributed to its hydroxy citric acid (HCA) content. This review aims to present a holistic overview on novel trends in the production of G . cambogia bioactive components and how extraction optimization is important to ensure best product quality with its reported nanoformulations with particular emphasis on HCA content. Further, an overview of the different analytical approaches used for quality control assessment of G . cambogia plant and its nutraceuticals is presented highlighting both advantages and limitations. Moreover, analytical approaches for detecting G . cambogia metabolites in biological fluids with emphasis on HCA level to determine its pharmacokinetics and proof of efficacy are presented for the first time.

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“…However, clinical trials reveal that NAFLD is responsive to medication (6). According to previous studies, patients with NAFLD are mainly obese or overweight; thus, reducing weight by about 10% of the initial weight during 6-12 months along with taking specific dietary supplements (including anti-oxidant and anti-inflammatory drugs, vitamins, nutraceuticals, and probiotics) appears to be efficient (22).…”

Section: Introductionmentioning

confidence: 99%

Mechanistic insights into the pleiotropic effects of butyrate as a potential therapeutic agent on NAFLD management: A systematic review

et al. 2022

Self Cite

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases worldwide. As a multifaceted disease, NAFLD’s pathogenesis is not entirely understood, but recent evidence reveals that gut microbiota plays a significant role in its progression. Butyrate, a gut microbiota metabolite, has been reported to have hepato-protective effects in NAFLD animal models. The purpose of this systematic review is to determine how butyrate affects the risk factors for NAFLD. Searches were conducted using relevant keywords in electronic databases up to March 2022. According to the evidence presented in this study, butyrate contributes to a wide variety of biological processes in the gut–liver axis. Its beneficial properties include improving intestinal homeostasis and liver health as well as anti-inflammatory, metabolism regulatory and anti-oxidative effects. These effects may be attributed to butyrate’s ability to regulate gene expression as an epigenetic modulator and trigger cellular responses as a signalling molecule. However, the exact underlying mechanisms remain unclear. Human trials have not been performed on the effect of butyrate on NAFLD, so there are concerns about whether the results of animal studies can be translated to humans. This review summarises the current knowledge about the properties of butyrate, particularly its potential effects and mechanisms on liver health and NAFLD management.

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The effect of hydroxy citric acid supplementation with calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in women with non-alcoholic fatty liver disease: a randomized controlled clinical trial

Abstract: Objective To examine effects of hydroxy citric acid (HCA) extracts from Garcinia cambogia (G.cambogia) on metabolic, atherogenic and inflammatory biomarkers in obese women with non-alcoholic fatty liver disease (NAFLD) Methods...

Cited by 13 publications

References 65 publications

Role of Sodium dependent SLC13 transporter and its inhibitors in various metabolic disorders

Role of Sodium dependent SLC13 transporter and its inhibitors in various metabolic disorders

Recent Advances in Garcinia cambogia Nutraceuticals in Relation to Its Hydroxy Citric Acid Level. A Comprehensive Review of Its Bioactive Production, Formulation, and Analysis with Future Perspectives

Mechanistic insights into the pleiotropic effects of butyrate as a potential therapeutic agent on NAFLD management: A systematic review

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