Effect of Dietary Intervention, with or without Cointerventions, on Inflammatory Markers in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Hall, Renate L.; George, Elena S.; Tierney, Audrey C.; Reddy, Anjana

doi:10.1016/j.advnut.2023.01.001

Cited by 5 publications

(2 citation statements)

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“…Among many inflammatory markers, TNFα has emerged as one of the key cytokines influencing intermediary metabolism and subsequently the development of metabolic diseases including MASLD (for overview see [ 36 ]). Indeed, results of animal and human intervention studies suggest that an attenuation of the development of MASLD and/or improvement of the disease is often afflicted with a lowering of Tnfa mRNA expression in liver tissue or circulating TNFα protein levels in blood [ 37 , 38 ]. However, molecular mechanisms underlying the devastating effects of TNFα in the development of MASLD have not yet been clarified.…”

Section: Discussionmentioning

confidence: 99%

TNFα is a key trigger of inflammation in diet-induced non-obese MASLD in mice

Burger,

Jung,

Baumann

et al. 2023

Redox Biology

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Section: Discussionmentioning

confidence: 99%

TNFα is a key trigger of inflammation in diet-induced non-obese MASLD in mice

Burger,

Jung,

Baumann

et al. 2023

Redox Biology

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“…A lifestyle intervention, the combination of diet, exercise, and behavior modification, is an effective and practical approach for managing NAFLD, also improving liver histology in NASH ( 21 ). Dietary interventions accompanied by supplementation have been suggested as the most effective approach for improving the inflammatory profile of patients with NAFLD ( 22 ). We previously showed that ginger essential oil (GEO) protects the liver from NAFLD by reducing hepatic lipid accumulation, oxidative stress, and inflammation ( 23 , 24 ).…”

Section: Introductionmentioning

confidence: 99%

Healthy diet intervention reverses the progression of NASH through gut microbiota modulation

Panyod,

Wu,

et al. 2024

Microbiol Spectr

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Diet and gut microbiota impact the progression of non-alcoholic steatohepatitis (NASH). An unhealthy diet, rich in fat and sugar, promotes gut microbiota dysbiosis, leading to the translocation of lipopolysaccharides (LPS) and other harmful pathogen-associated molecular patterns to the liver, triggering hepatic inflammation and aggravating NASH. Currently, there are no approved pharmacological treatments for NASH, although novel drugs, such as obeticholic acid (OCA), have demonstrated beneficial effects. Healthy dietary modifications have been proposed to prevent and treat NASH. However, the therapeutic effect of the combined implementation of a healthy dietary intervention with pharmaceutical agents or dietary supplements for NASH treatment and how it interplays with the gut microbiota and associated pathways remains poorly understood. This study aims to investigate the therapeutic efficacy of a healthy dietary modification, either alone or in combination with a dietary supplement [ginger essential oil (GEO)] or drug (OCA), in a Gubra-Amylin diet-induced NASH mouse model. NASH was induced for 12 weeks, after which the interventions were administered for a subsequent 3-week period. Our findings revealed that healthy dietary intervention primarily restores obesity, lipidemia, and NASH. In contrast, GEO and OCA have additional benefits by suppressing pro-inflammatory cytokines by partially modulating the NLRP3/ASC/caspase-1 pathways. Moreover, healthy dietary intervention restores gut microbiota composition and function from dysbiosis, while GEO and OCA partially mediate the gut-derived LPS/toll-like receptor 4/nuclear factor kappa B pathway. Therefore, adherence to healthy dietary patterns plays a primary role in NASH reversion, and additional supplementation of GEO or OCA could offer extra benefits in suppressing hepatic inflammation and preventing disease progression. IMPORTANCE The link between gut microbiota and diet is crucial in the development of non-alcoholic steatohepatitis (NASH). This study underscores the essential role of a healthy diet in preventing and treating NASH by reversing obesity, lipidemia, and gut microbiota dysbiosis. Moreover, the supplementation of functional food or drug to the diet can provide additional advantages by inhibiting hepatic inflammation through the modulation of the hepatic inflammasome signaling pathway and partially mediating the gut microbiota and lipopolysaccharide signaling pathway. This study highlights the importance of adopting healthy dietary habits in treating NASH and proposes that supplementing with ginger essential oil or obeticholic acid may offer additional benefits. Nonetheless, further clinical studies are necessary to validate these findings.

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