Effects of honokiol and magnolol on acute and inflammatory pain models in mice

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

“…(Maruyama and Kuribara, 2000). Magnolol and honokiol are two hydroxylated biphenolic isomers (neolignans, C 18 H 18 O 2 ) (Lin et al, 2007), the orthoortho-C-C and ortho-para-C-C dimers of 4-allylphenol, respectively (Kong et al, 2005) (Table 3).…”

“…An impressive series of studies has shown that all of these major indicators are positively impacted by Magnolia lignans, even if the full anti-inflammatory mechanisms have not yet been elucidated (Choi et al, 2007;Lin et al, 2007;Munroe et al, 2007;Kang et al, 2008;Lee et al, 2011). Upregulating signaling cascades composed of Ras, Raf, and MAPK, downregulating the activation of NF-κB, and blocking NF-κB activation mediated by CD40 and latent membrane protein 1 are speculated to be the action mechanism of Magnolia lignans (Lin et al, 2007;Kim and Cho, 2008;Lee et al, 2011).…”

“…Among the lignans (Table 7), honokiol and magnolol were notably shown to inhibit the formation of eicosanoids (prostaglandin D2 (PGD2), PGE2, leukotriene C4 (LTC4), LTB4, and thromboxane B2 (TXB2)), probably through inhibition of phospholipase A2, COX, 5-lipoxygenase, LTC4 synthase, and LTA4 hydrolase activities (Lin et al, 2007).…”

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i>

“…The potent activity of honokiol and magnolol appears to be due to the presence of hydroxyl and allylic groups on a biphenolic moiety (10 Magnolol, a hydroxylated biphenyl compound isolated from the stem bark of Magnolia officinalis, is commonly used to treat acute pain, cough, anxiety, and gastrointestinal disorders in East Asia (11). Various pharmacological actions have been reported for magnolol, including anti-inflammatory activity, antimicrobial activity (12), antiperoxidative activity (13), anti-coagulatory activity, anti-oxidant activity (14), neuroprotective activity (15), antitumor action (16)(17)(18), alleviation of inflammatory pain (19), and protection of cortical neuronal cells from chemical hypoxia (20).…”

Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes

“…1) is the major component isolated from the bark of the roots and stems of various Magnolia species (5). To date, various pharmacological effects of honokiol, such as neuroprotective, anticancer, cardiotonic, and anti-inflammatory activities have been reported (6)(7)(8). It is believed that the molecular mechanisms involved in honokiol pharmacology are managed by modulation of a signaling cascade composed of Ras, Raf, the extracellular signal-regulated kinase (ERK), and NF-κB/IκB kinase (IKK) in response to TNF-α or LPS stimulation and via control of the cellular redox system (9,10).…”