Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes

Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation

“…However, in the present study, treatment with honokiol (5 mg/kg) in CLP-induced septic mice did not decrease the CFUs in peritoneal fluid, indicating that honokiol may not exert the anti-bacterial effect under this experimental condition. On the other hand, honokiol appeared to block the production of cytotoxic cytokines such as interleukin (IL)-1b and TNF-a, NO, and reactive oxygen species (ROS) in LPS or phorbol-12-myristate-13-acetate-treated macrophages and monocytes [38]. Lee et al [39] have shown that magnolol and honokiol could inhibit the NF-jB element, which exists in cyclooxygenase-2, IL-8, and TNF-a promoters in monocytic cells to exert their anti-inflammatory effects.…”

Honokiol Decreases Intra-Abdominal Adhesion Formation in a Rat Model

“…In molecular studies, Honokiol was reported to block lipopolysaccharide-induced cytotoxicity and production of cytotoxic cytokines such as interleukin-1β and tumor necrosis factor-α, nitric oxide, and reactive oxygen species [40]. Honokiol was also shown to be an effective scavenger of both superoxide and peroxyl radicals, which confirms its antioxidant effects [41].…”

Modified Da Chengqi granules improvement in immune function in early severe acute pancreatitis patients

“…Pinellia tuber and Magnoliaeofficinalis have anxiolytic and antiemetic effects. Furthermore, they help remove qi stagnation, regulate gastrointestinal function and cellular immunity (Lee and Cho, 2009;Park et al, 2010;Weng et al, 2012), protect gastric mucosa (Wu et al, 2010), and reduce the expression of inflammatory mediators. Taken together, the theory of "the lung and the large intestine being interiorexteriorly related" appears to work.…”