Effects of High-Intensity Interval Exercise Training on Skeletal Myopathy of Chronic Heart Failure

Tzanis, Georgios; Philippou, Αnastassios; Karatzanos, Eleftherios; Dimopoulos, Stavros; Kaldara, Elisavet; Nana, Emmeleia; Pitsolis, Theodoros; Rontogianni, Dimitra; Koutsilieris, Michael; Nanas, Serafim

doi:10.1016/j.cardfail.2016.06.007

Cited by 31 publications

(52 citation statements)

References 38 publications

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“…Therefore, it is not unexpected that rehabilitation programmes that involve strength and/or cardiovascular exercise training can improve exercise tolerance. Exercise training increases peripheral muscle capillarisation, which improves peripheral muscle O 2 utilisation and delays the onset of metabolic acidosis, resulting in a lower ventilatory demand at any given workload [115][116][117][118][119][120]. Furthermore, it has been demonstrated that exercise training reduces exercise oscillatory ventilation and V′E/V′CO 2 in CHF patients [121], suggesting beneficial effects of exercise on central and peripheral autonomic chemo/ ergoreflexes in cardiopulmonary diseases [80,122].…”

Section: The Role Of Ventilation-perfusion Heterogeneity and Vt In Vementioning

confidence: 99%

Ventilatory response to exercise in cardiopulmonary disease: the role of chemosensitivity and dead space

et al. 2018

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The lungs and heart are irrevocably linked in their oxygen (O) and carbon dioxide (CO) transport functions. Functional impairment of the lungs often affects heart function and The steepness with which ventilation (') rises with respect to CO production (' ) ( the '/' slope) is a measure of ventilatory efficiency and can be used to identify an abnormal ventilatory response to exercise. The '/' slope is a prognostic marker in several chronic cardiopulmonary diseases independent of other exercise-related variables such as peak O uptake (' ). The '/' slope is determined by two factors: 1) the arterial CO partial pressure ( ) during exercise and 2) the fraction of the tidal volume () that goes to dead space () ( the physiological dead space ratio (/)). An altered set-point and chemosensitivity are present in many cardiopulmonary diseases, which influence'/' by affecting Increased ventilation-perfusion heterogeneity, causing inefficient gas exchange, also contributes to the abnormal'/' observed in cardiopulmonary diseases by increasing / During cardiopulmonary exercise testing, the during exercise is often not measured and/ is only estimated by taking into account the end-tidal CO partial pressure ( ); however, is not accurately estimated from in patients with cardiopulmonary disease. Measuring arterial gases ( and ) before and during exercise provides information on the real (and not "estimated")/ coupled with a true measure of gas exchange efficiency such as the difference between alveolar and arterial O partial pressure and the difference between arterial and end-tidal CO partial pressure during exercise.

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Section: The Role Of Ventilation-perfusion Heterogeneity and Vt In Vementioning

confidence: 99%

Ventilatory response to exercise in cardiopulmonary disease: the role of chemosensitivity and dead space

et al. 2018

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“…cantó et al (8), revealed that aMP-activated protein kinase (aMPK) is first activated during the adaptive responses in skeletal muscle after exercise, while sirtuin 1 (SirT1) is activated with deficient aMPK activity, suggesting an acetylation regulation mechanism of the aMPK/SirT1 axis. High-intensity intermittent exercise training (HiiT) improves the skeletal myopathy in patients with heart failure associated with the increased expression of the insulin-like growth factor 1 bioregulation system (9). exercise training can induce the increased expression level of cytokines secreted by skeletal muscle cells, including il-6, il-1 and IL-10, which have anti-inflammatory effects (10).…”

Section: Introductionmentioning

confidence: 99%

miR‑29 mediates exercise‑induced skeletal muscle angiogenesis by targeting VEGFA, COL4A1 and COL4A2 via the PI3K/Akt signaling pathway

Chen

Bai

2020

Mol Med Rep

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The present study investigated the molecular changes and related regulatory mechanisms in the response of skeletal muscle to exercise. The microarray dataset 'GSe109657' of the skeletal muscle response to high-intensity intermittent exercise training (HiiT) was downloaded from the Gene expression omnibus database. differentially expressed genes (deGs) were screened and analyzed using weighted gene co-expression network analysis (WGcna) to identify the significant functional co-expressed gene modules. Moreover, functional enrichment analysis was performed for the deGs in the significant modules. In addition, protein-protein interaction (PPi) network and microrna (mir)-transcription factor (TF)-target regulatory network were constructed. a total of 530 deGs in the skeletal muscle were screened after HiiT, suggesting an effect of HiiT on the skeletal muscle. Moreover, three significant modules (brown, blue and red modules) were identified after WGCNA, and the genes Collagen Type IV α1 chain (col4a1) and col4a2 in the brown module showed the strongest correlation with HiiT. The deGs in the three modules were significantly enriched in focal adhesion, extracellular matrix organization and the Pi3K/akt signaling pathway. Furthermore, the PPi network contained 104 nodes and 211 interactions. Vascular endothelial growth factor A (VEGFA), COL4A1 and COL4A2 were the hub genes in the PPi network, and were all regulated by mir-29a/b/c. in addition, VEGFA, COL4A1 and COL4A2 were significantly upregulated in the skeletal muscle response to HiiT. Therefore, the present results suggested that the growth and migration of vascular endothelial cells, and skeletal muscle angiogenesis may be regulated by miR-29a/b/c targeting VEGFA, COL4A1 and col4a2 via the Pi3K/akt signaling pathway. The present results may provide a theoretical basis to investigate the effect of exercise on skeletal muscle.

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“…The patients had a mean and standard deviation age of 51 ± 13 years 36 and 63 ± 9 years. 37 In six studies, patients had NYHA functional class ≤ III, 31---36,38---40 in three NYHA functional class between II and III, 33,38,40 and a NYHA functional class between II and IV.…”

Section: Characteristics Of Patientsmentioning

confidence: 99%

“…40 All IT protocols were performed on a stationary bicycle, and the 30 s/60 s (effort/rest) ratio was predominant, with total duration of sessions last between 15 and 45 min, 31,32,34,35,37,38,40 except for two studies that used 120 s/120 s 33,39 and a study that used 240 s/180 s. 36 The intensities of the interval exercise ranged from 50%W peak , 31,32,34,35,38,40 80---100% W peak 37 and 40---80%VO 2peak . 33,36,39 Regarding TR, the majority of the studies used four exercises 31,32,34,37,35 with the exception of those who used ten, 39 six, 33 five, 38 three 40 or two 36 exercises per session. The load intensity ranged from 60 to 80% of one maximum repetition (MR) 33,36---40 and 55---65% of two MR. 31,32,34,35 Details of training groups and protocols are highlighted in Table 3.…”

Section: Characteristics Of Protocolsmentioning

confidence: 99%

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Effect of combined interval training on the cardiorespiratory fitness in heart failure patients: a systematic review and meta-analysis

Jesus

Menezes-Junior

Bento

et al. 2020

Brazilian Journal of Physical Therapy

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Background: The combination of interval training and resistance training has showed interesting results in chronic heart failure patients, corroborating the benefits of physiological adaptations of both protocols. Objective: To evaluate the effect of the combination of interval training and resistance training program when compared to interval training alone and/or without intervention group on cardiorespiratory fitness in patients with chronic heart failure. Methods: We search MEDLINE via PubMed, ScienceDirect, Sportdiscus, BIREME and Scielo, from their inception to December 2018. Were included both randomized and non-randomized controlled trials comparing the effect of combined training, interval training alone and/or WI group on VO 2peak (expressed in ml/kg/min), in people with chronic heart failure patients. The meta-analysis was conducted via Review Manager v 5.3 software, using random effect model. Results: Ten articles were selected (nine randomized controlled trial), involving 401 participants. Six studies compared combined training with interval training and six studies compared combined training with the without intervention group. Eighty percent of the trials presented moderate risk of bias and twenty percent low risk of bias. Data showed significant difference and major increase in VO 2peak in favor to combined training group compared to interval training group (SMD = 0.25; CI = 0.04-0.46) and without intervention group (SMD = 0.46; CI = 0.29-0.64), respectively.

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Effects of High-Intensity Interval Exercise Training on Skeletal Myopathy of Chronic Heart Failure

Cited by 31 publications

References 38 publications

Ventilatory response to exercise in cardiopulmonary disease: the role of chemosensitivity and dead space

Ventilatory response to exercise in cardiopulmonary disease: the role of chemosensitivity and dead space

miR‑29 mediates exercise‑induced skeletal muscle angiogenesis by targeting VEGFA, COL4A1 and COL4A2 via the PI3K/Akt signaling pathway

Effect of combined interval training on the cardiorespiratory fitness in heart failure patients: a systematic review and meta-analysis

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