Effects of High-Intensity Interval and Moderate-Intensity Continuous Exercise on Inflammatory, Leptin, IgA, and Lipid Peroxidation Responses in Obese Males

Souza, Daniel; Matos, Victor Araújo Ferreira; Santos, Victor Oliveira Albuquerque dos; Medeiros, Ítalo Freire; Marinho, Cristiane da Silva Ramos; Nascimento, Paulo Ricardo Porfírio do; Dorneles, Gilson Pires; Peres, Alessandra; Muller, Carlos Henrique de Lemos; Krause, Maurício; Costa, Eduardo Caldas; Fayh, Ana Paula Trussardi

doi:10.3389/fphys.2018.00567

Cited by 56 publications

(51 citation statements)

References 46 publications

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“…Increased IFNγ levels during obesity have been associated with the development of M1 polarization and impairment of AT homeostasis during high-fat-diet-induced immunometabolic dysfunction in the early stages [5]. Consistent with previous findings, the IFNγ level was decreased following our exercise training protocol [44,52]. Although this decrease was not statistically significant, it seems that IFNγ reduction effectively decreases the production of TNF-α as an inflammatory cytokine.…”

Section: Discussionsupporting

confidence: 90%

Combined All-Extremity High-Intensity Interval Training Regulates Immunometabolic Responses through Toll-Like Receptor 4 Adaptors and A20 Downregulation in Obese Young Females

Soltani¹,

Marandi²,

Kazemi³

et al. 2020

Obes Facts

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Metainflammation and malfunctions of toll-like receptor 4 (TLR4) are related to obesity-induced immunometabolic morbidities. There are almost no studies relating exercise training to the TLR4 pathway and its adaptors and negative regulators. Thirty young women with obesity (exercise group and control group) were included in a 10-week all-extremity combined high-intensity interval training program. The immunomodulatory impacts of exercise on TLR4, its related adaptors (TIR domain-containing adaptor-inducing IFN-β [TRIF], myeloid differentiation factor 88 [MyD88], and tumor receptor-associated factor 6 [TRAF6]), transcriptional factors (nuclear factor [NF]-κB and interferon regulatory factor 3 [IRF3]), and negative regulator (A20) mRNA levels were assessed by real-time PCR. Also, the serum concentration of TLR4 final products (tumor necrosis factor α [TNFα] and interferon γ [IFNγ]) was measured by ELISA. Cardiorespiratory and body composition parameters were tested, as well. There was a significant improvement in body composition and cardiorespiratory fitness. This intervention downregulated TLR4 (from 2.25 ± 1.07 to 0.84 ± 1.01), MyD88 (from 4.53 ± 5.15 to 1.27 ± 0.88), NF-κB (from 1.61 ± 2.03 to 0.23 ± 0.39), IRF3 (from 1.22 ± 0.77 to 0.25 ± 0.36), and A20 (from 0.88 ± 0.59 to 0.22 ± 0.33) levels and reduced the TNFα concentrations (from 22.39 ± 11.43 to

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Section: Discussionsupporting

confidence: 90%

Combined All-Extremity High-Intensity Interval Training Regulates Immunometabolic Responses through Toll-Like Receptor 4 Adaptors and A20 Downregulation in Obese Young Females

Soltani¹,

Marandi²,

Kazemi³

et al. 2020

Obes Facts

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“…Despite the classical role in acute proinflammatory response in pathological conditions, acute changes in IL‐6 levels after exercise are responsible to the induction of transient anti‐inflammatory state after the exercise . In this way, elevations of IL‐6 levels after HIIE were accompanied by increases of anti‐inflammatory cytokines, mainly IL‐4 and IL‐10, in a time‐dependent manner . In sedentary but otherwise healthy obese individuals, an acute bout of HIIE increased the levels of immunoregulatory IL‐6 and IL‐10 without changes in proinflammatory cytokines (ie, IL‐8, TNF‐α, and MCP‐1) …”

Section: Discussionmentioning

confidence: 99%

Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

et al. 2018

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This study investigated the acute and chronic effects of 4 weeks of High Intensity Interval Training (HIIT) on cytokines and oxidative stress markers in postmenopausal obese women. Ten post‐menopause sedentary obese women (age 58.25 ± 3.10 years; BMI 31.70 ± 1.34 kg/m²) performed 4 weeks of high intensity interval exercise (60 seconds of effort at 85%‐90% Maximal Heart Rate interspersed by 75 seconds of recovery at sessions of 40% Maximal Heart Rate) twice a week. Blood samples were collected before and immediately after the first and the last (8th) high intensity interval exercise (HIIE) session to analyze interleukin(IL)‐1β, IL‐1ra, IL‐6, IL‐10, monocyte chemoattractant protein‐1 (MCP‐1) levels and lipid peroxidation (TBARS), nitrites, and advanced oxidation protein products (AOPP). An elevation in MCP‐1, IL‐6, and IL‐10 levels and in TBARS and AOPP occurred immediately after the first HIIE. After 4 weeks of HIIT, the participants presented lower levels of IL‐6 and higher amounts of IL‐1ra and IL‐10 at rest. The last HIIE session induced an elevation only in IL‐6, IL‐10, and IL‐1ra levels, but not in MCP‐1, IL‐1β, and TBARS levels. In conclusion, HIIT induced anti‐inflammatory effects in postmenopausal obese women, with little changes in oxidative stress markers.

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“…Serum levels of C-reactive protein (CRP) in our investigated patient group were generally low ( Table 1) and probably re ecting ongoing immunosuppressive treatment and low disease activity and did not change during the intervention. Bene cial effects of physical activity on in ammation and possible mechanisms of antiin ammatory effects of exercise have been reported in other studies and one suggested explanation being by reduction in body fat [35][36] . The improved fatty acid metabolism and enhanced ATP production due to changes in the mitochondrial machinery demonstrated in our work might also contribute to the anti-in ammatory effect of physical activity.…”

Section: Discussionmentioning

confidence: 57%

Effects of a two-year health-enhancing physical activity program on skeletal muscle protein profiles in people with rheumatoid arthritis

Ossipova

Idborg

Fridén

et al. 2020

Preprint

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Background Rheumatoid arthritis (RA) induces loss of muscle mass and impairments, which discourage physical activity. Consequently, RA is associated with decreased levels of exercise. Positive effects of exercise on physical and mental health without increasing pain or disease activity have been demonstrated but the influence of moderate-intensity physical activity on the molecular effects in skeletal muscle in people with RA remains unclear. In this pilot study we investigated the impact of a two-year health-enhancing physical activity (HEPA) program on protein profiles in skeletal muscle biopsies from people with RA based on a unique set of interdisciplinary variables. Methods Six people with RA participated. Muscle biopsies were taken from m. vastus lateralis, and perceived disease impact, anthropometrics and physical capacity tests were assessed at baseline and year 1 and 2. Mass spectrometry-based quantitative proteomics and immunohistochemistry analysis were employed to examine molecular changes in the skeletal muscle in response to long-term HEPA. Results The study participants had moderate to low adherence to the HEPA program, the perceived disease impact and anthropometric parameters were not altered. Among the physical capacity tests, the Timed-stands test showed a significant improvement after one year. Mean pressure pain threshold was significantly reduced after 1- and 2-year HEPA participation. Proteome analysis of the muscle biopsies showed an up-regulation of proteins in the mitochondrial respiratory chain and predicted increased ATP production and improved muscle contractility in response to HEPA. Molecular pathways identified by proteome analysis revealed correlations to pain variables. Conclusions Our results indicate that long-term physical activity in people with RA may up-regulate proteins in the mitochondrial respiratory chain predicting increased ATP production and muscle contractility similar to what has been reported in healthy young men and might have a positive impact on muscle tissue by decreased muscle cell death.

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Effects of High-Intensity Interval and Moderate-Intensity Continuous Exercise on Inflammatory, Leptin, IgA, and Lipid Peroxidation Responses in Obese Males

Cited by 56 publications

References 46 publications

Combined All-Extremity High-Intensity Interval Training Regulates Immunometabolic Responses through Toll-Like Receptor 4 Adaptors and A20 Downregulation in Obese Young Females

Combined All-Extremity High-Intensity Interval Training Regulates Immunometabolic Responses through Toll-Like Receptor 4 Adaptors and A20 Downregulation in Obese Young Females

Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

Effects of a two-year health-enhancing physical activity program on skeletal muscle protein profiles in people with rheumatoid arthritis

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