Effects of High-Frequency Bio-Oxidative Ozone Therapy in Temporomandibular Disorder-Related Pain

Abstract

Objective: It was the aim of this study to compare the efficacy of ozone therapy and drug treatment in patients with painful temporomandibular joint (TMJ) disorder (TMD). Subjects and Methods: A total of 63 patients with TMD were enrolled; 33 were treated with bio-oxidative therapy and 30 with a ketoprofen tablet thiocolchicoside capsule 2 × 1 for 7 days. Maximum voluntary interincisal mouth opening (MMO) was measured in millimeters using a scale and recorded during the pre- and posttreatment periods. The patients evaluated their subjective pain using a visual analogue scale (VAS). Data were analyzed using the Mann-Whitney U test, the Kolmogorov-Smirnov test, and the independent t test. Results: The mean MMO of the group that received ozone therapy during the pretreatment period was 46.51 ± 8.2 mm, and it immediately increased to 48.78 ± 7.5 mm after 1 week of ozone therapy, which was statistically significant (p = 0.04). For those who received medication, the mean MMO during the pretreatment period was 46.30 mm, and at the end of 1 week it was 46.9 mm. In the ozone group, 29% of patients showed a gradual decrease in their VAS pain scores compared to pretreatment values (6.3 ± 2.1 to 3.0 ± 2.2). In the medication group, 24% of patients showed a significant decrease in VAS pain scores during the follow-up period (6.9 ± 1.4 to 5.0 ± 1.5). Conclusion: This study showed that bio-oxidative therapy was a more effective treatment than medication therapy for relieving TMJ pain.

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

“…This resource uses ozone as a therapeutic agent, whose potent oxidizing effect stimulates biochemical events during cellular metabolism, besides having antimicrobial, bactericidal and fungicidal effects 9,[16][17][18] .…”

Analysis of electric field and emission spectrum in the glow discharge of therapeutic plasma electrode

“…In view of the above clinical reports [17][18][19]25], we propose a hypothesis that not only bio-oxidative effects of ozone but also the effects of emission spectrum and electric field, which are generated by the glow discharge of the plasma electrode ( Figure 1), and therefore are present in the treatment field, have to be taken into consideration as bioactive components in course of such treatment. By our knowledge, there are no reports in the appropriate literature regarding the presence or quantification of the named factors in the treatment field during the procedure.…”

“…A clinical evaluation of such method indicates positive results in disinfection [13][14][15] post-surgical soft tissue and bone healing and pain relief [16][17][18][19][20], treatment of various oral and dental diseases [21][22][23][24], reduction of temporomandibular disorder-related pain [25], and bisphosphonate-related osteonecrosis of the jaw [26]. In recent available literature found on the clinical application of plasma electrode coupled with high-frequency generator, all of the reported therapeutic effects are generally ascribed to bio-oxidative effects of ozone [14][15][16][17][18][19][20][21][22][23][24][25][26].…”

“…However, in the treatment modes when plasma electrode is applied in direct contact with the treated surface (especially in treatment of tissues underlying intact skin) or is immersed in liquids (e.g. saliva or blood), in which DBD and ozone generation are limited or even missing (Figure 1(d)), therapeutic effects, like improved bone healing and pain reduction, are still observed [17][18][19]25].…”

“…They also reported improvement in wound healing accompanied by an increase in the quality of life and decrease in postoperative pain. Do gan et al [25] reported application of the plasma electrode (Omega probe, for 10 min, three times in one week) applied to the skin in the projection of underlying temporomandibular joint (TMJ) to be more effective treatment than medication therapy for relieving TMJ-related pain.…”