Effects of Helium Cold Plasma on Erythrocyte Metabolism

Мартусевич, А. К.; Соловьева, А. Г.; Galka, A. G.; Kozlova, L A; Yanin, D. V.

doi:10.1007/s10517-019-04490-4

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…The experiments carried out to evaluate the systemic effects of inert gases (using the example of helium and argon) allowed us to establish that the gases in question contribute to the formation of a special reaction of oxidative metabolism [13,[16][17][18][20][21][22][23][24][25]. In particular, the use of helium flux is a «milder» agent, only moderately but significantly enhancing free radical oxidation, but to a predominant extent increasing the antioxidant potential [12,13,19,21,24]. This is due to adaptive stimulation of the catalytic activity of the main antioxidant enzymes-catalase and superoxide dismutase; however, their induction does not go beyond physiological limits [13].…”

Section: Discussionmentioning

confidence: 99%

“…Some publications present hypotheses about the molecular mechanisms of favorable such effects [2,4,5,7,11]; however, a comprehensive analysis of the problem is necessary to form a full-fledged concept. In particular, considering the data on free radical processes as a universal "biosensor" of various physical and chemical influences [2,7,[12][13][14], it is of interest to assess the state of redox processes in biological systems under the action of inert gases, but these data are not available in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

Мартусевич

Surovegina

Поповичева

et al. 2022

BioMed Research International

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The aim of the study was to assess the effect of external use of inert gases (helium and argon) on the state of free radical processes in vivo. The experiment was performed on 30 male Wistar stock rats (age-3 months, weight–200-220 g.), randomly distributed into 3 equal groups. The first group of animals was intact ( n = 10 ). The animals of the second and third groups were treated with argon and helium streams, respectively. Our research has allowed us to establish that the studied inert gases have a modulating effect on the state of oxidative metabolism of rat blood, and the nature of this effect is directly determined by the type of gas. The results of this study allowed us to establish the potential antioxidant effect of the helium stream, mainly realized due to the activation of the catalytic properties of the enzymatic link of the antioxidant system of rat blood plasma. At the same time, the revealed features of shifts in oxidative metabolism during treatment with argon flow include not only stimulation of the antioxidant system but also the pronounced induction of free radical oxidation. Thus, the conducted studies made it possible to verify the specificity of the response of the oxidative metabolism of blood plasma to the use of inert gases, depending on their type.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

Мартусевич

Surovegina

Поповичева

et al. 2022

BioMed Research International

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“…Human whole blood samples served as the main test biosystem, convenient and indicative in terms of evaluating the effects of cold plasma in experiments in vitro. It was found that cold helium plasma modifies various components of blood plasma metabolism [ 52 , 53 ] and erythrocytes [ 54 ]. In particular, in blood plasma, the studied factor induced moderate stimulation of free radical processes with a short exposure (1–2 min) against the background of more pronounced activation of the antioxidant system [ 52 ].…”

Section: The Authors’ Own Research In the Field Of Studying Local And...mentioning

confidence: 99%

Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities

et al. 2022

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Currently, plasma medicine is a synthetic direction that unites the efforts of specialists of various profiles. For the successful formation of plasma medicine, it is necessary to solve a large complex of problems, including creating equipment for generating cold plasma, revealing the biological effects of this effect, as well as identifying and justifying the most promising areas of its application. It is known that these biological effects include antibacterial and antiviral activity, the ability to stimulate hemocoagulation, pro-regenerative properties, etc. The possibility of using the factor in tissue engineering and implantology is also shown. Based on this, the purpose of this review was to form a unified understanding of the biological effects and biomedical applications of argon cold plasma. The review shows that cold plasma, like any other physical and chemical factors, has dose dependence, and the variable parameter in this case is the exposure of its application. One of the significant characteristics determining the specificity of the cold plasma effect is the carrier gas selection. This gas carrier is not just an ionized medium but modulates the response of biosystems to it. Finally, the perception of cold plasma by cellular structures can be carried out by activating a special molecular biosensor, the functioning of which significantly depends on the parameters of the medium (in the field of plasma generation and the cell itself). Further research in this area can open up new prospects for the effective use of cold plasma.

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“…This antibacterial mechanism may be involved in the antibacterial study to kill the S. aureus microorganisms. It is proven that plasma jet therapy inhibits germs from growing on hard surfaces and in liquid settings [41][42][43][44][45][46][47][48][49][50][51][52][53]. As a result, researchers are looking into the effects of plasma jet therapy on both gram negative and gram positive bacteria.…”

Section: -5-antibacterial Activitymentioning

confidence: 99%

Effect of Applying Cold Plasma on Structural, Antibacterial and Self Cleaning Properties of α-Fe2O3 (HEMATITE) Thin Film

2022

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Objective: In this study, α-Fe2O3 thin film was formed on a glass substrate to study the impact of adding cold plasma on the self-cleaning and antibacterial properties of the samples. Method: The samples were synthesized using the chemical spray pyrolysis (CSP) method at 450°C. X-ray powder diffraction (XRD), scanning electron microscope (FESEM), energy-dispersive X-ray spectroscopy (EDS), and atomic force microscope were used to investigate the morphological and structural characteristics of α-Fe2O3 thin layers prior to and following plasma injection. Finding: The degree of wettability and antibacterial characteristics of iron oxide (hematite) thin film were evaluated in the presence of gram-negative and gram-positive bacteria prior to and following plasma injection, given the great potential of plasma injection in the surface modification of thin films. Novelty: The findings indicate that exposing plasma to α-Fe2O3thin film produces substantial changes in morphology, self-cleaning, and antibacterial characteristics. Doi: 10.28991/ESJ-2022-06-01-06 Full Text: PDF

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Effects of Helium Cold Plasma on Erythrocyte Metabolism

Cited by 8 publications

References 9 publications

Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities

Effect of Applying Cold Plasma on Structural, Antibacterial and Self Cleaning Properties of α-Fe2O3 (HEMATITE) Thin Film

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