Effects of graded infusion rates of propofol on cardiovascular haemodynamics, coronary circulation and myocardial metabolism in dogs

Abstract

We have studied the effects of a 30-min infusion of propofol 6, 9, 12, 15, 18 and 21 mg kg-1 h-1 on cardiovascular haemodynamics, coronary circulation and myocardial metabolism in 12 mongrel dogs. Mean plasma concentrations of propofol after infusion of 6 and 21 mg kg-1 h-1 increased from 2.9 (SEM 0.3) to 11.5 (0.1) micrograms ml-1. Propofol produced a progressive decrease in arterial pressure. Heart rate tended to decrease at 15, 18 and 21 mg kg-1 h-1 and cardiac index decreased significantly at infusion rates > or = 9 mg kg-1 h-1. Systemic vascular resistance tended to increase except at 21 mg kg-1 h-1 and left ventricular systolic and diastolic function were depressed. Both coronary sinus blood flow and myocardial oxygen consumption decreased in parallel with a decrease in left ventricular minute work index without producing lactate. Propofol produced progressive decreases in coronary blood flow and myocardial oxygen consumption but did not exert adverse effects on the coronary circulation.

Evaluation of the clinical and cardiorespiratory effects of propofol microemulsion in dogs

“…According to NAKAIGAWA et al (1995), the CI decrease is related to the change in SVI during propofol anesthesia and it is believed that the same situation happened on our study (Figure 1). Changes in SVI depend on several factors, such as changes in preload and in myocardial contractility.…”

Cardiovascular Effects of Continuous Propofol Infusion in Horses

“…It is reported that SV and CO decreased during propofol anesthesia in human [13], pig [9] and dog [18] similar to other anesthetics. However, there is another report in human where propofol did not influence SV or CO probably because some depressive effects of propofol on cardiovascular system was masked by the effects of increased PaCO 2 caused by moderate respiratory impairment [8].…”

Amplification by Hyperoxia of Coronary Vasodilation Induced by Propofol

“…In vivo, propofol produces a decrease in myocardial blood flow and Mvo 2 (1,2). Although numerous in vitro studies reported a coronary vasodilation, previous results remain a subject of controversy.…”

“…T he attractive pharmacokinetic properties of propofol and the use of new anesthetic techniques, such as the target-controlled infusion technique, explain the increased use of propofol. In vivo, propofol induces a decrease in myocardial blood flow and myocardial oxygen consumption (1,2). Although in vitro studies reported significant coronary effects of propofol, these results are variable (3)(4)(5)(6)(7)(8)(9)(10).…”