Cardiovascular Effects of Continuous Propofol Infusion in Horses

Abstract

ABSTRACT. We examined the influence of propofol infusion on cardiovascular system at the rate of 0.14, 0.20 and 0.30 mg/kg/min in six adult Thoroughbred horses. The cardiovascular parameters were heart rate (HR), mean arterial pressure (MAP), mean right atrial pressure (MRAP), stroke volume (SV), cardiac output (CO), systemic vascular resistance (SVR), pre-ejection period (PEP) and ejection time (ET). In order to keep the ventilation conditions constantly, intermittent positive pressure ventilation was performed, and the partial arterial CO 2 pressure was maintained at 45 to 55 mmHg during maintenance anesthesia. SV showed a significant dose-dependent decrease however, CO did not show significant change. SVR decreased significantly at higher dose. PEP was prolonged and PEP/ET increased significantly at the highest dose. From these results, it became clear that SV decreases dose-dependently due to decrease of cardiac contractility during anesthesia with continuous propofol infusion in horses. On the other hand, since MAP and CO did not show significant changes, total intravenous anesthesia with propofol was suggested to be suitable for long-term anesthesia in horses.

The effects of different inspired oxygen fractions on gas exchange and Tei‐index of myocardial performance in propofol‐anesthetized dogs

“…In this study, during maintenance of anesthesia, stability of PEP, LVET and PEP/LVET was recorded in agreement with Oku et al. (). In awake dogs breathing room air, Sousa et al.…”

“…In propofol‐anesthetized horses, PEP prolongation and PEP/LVET increases were observed when the CRI was increased (0.14; 0.20 and 0.30 mg kg −1 minute −1 ) (Oku et al. ). In this study, no differences were observed among treatments for PEP because in all treatments, the same CRI was used.…”

Cardiopulmonary effects of dexmedetomidine and ketamine infusions with either propofol infusion or isoflurane for anesthesia in horses

“…Similar hemodynamic stability was also observed in horses using the same propofol infusion rate where no changes in or SVR, and minimal effect on MAP, were reported (Oku et al. ).…”

“…Propofol is a suitable drug for PIVA and TIVA techniques because of its ideal pharmacokinetic profile (Oku et al. , ; de Vries et al. ).…”

Clinical Evaluation of Total Intravenous Anesthesia Using a Combination of Propofol and Medetomidine following Anesthesia Induction with Medetomidine, Guaifenesin and Propofol for Castration in Thoroughbred Horses

“…Arterial blood pressure was lower compared with that of conscious horses [26], but it did not change significantly during anesthesia. The possible causes of the decrease in HR and arterial blood pressure include a cardiovascular depressant effect of medetomidine [26] and propofol [14,23]. Guaifenesin may also have contributed to the decrease in arterial blood pressure, since it is known to cause a significant decrease in arterial blood pressure without significantly changing HR and cardiac output in horses [13].…”