Effects of gold core size on regulating the performance of doxorubicin-conjugated gold nanoparticles

Wu, Dongling; Wang, Huaisong; Hou, Xia; Chen, Huan; Ma, Yu; Hou, Yanglong; Hong, Jin; Ding, Ya

doi:10.1007/s12274-017-1963-y

Cited by 25 publications

(12 citation statements)

References 38 publications

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“…In general, optimal NP size for cellular uptake is ∼50−60 nm. 31 If cytotoxicity originates solely from the amount of NPs uptake, then 65 nm Cu 2−x Se NPs would be expected to be more toxic to cells, which differs from the experimental observations. Thus, we tentatively ascribe the observed size-dependent cytotoxicity to a surface effect, as the surface copper atoms per unit weight NPs will be inversely proportional to the particle diameter.…”

Section: ■ Results and Discussionmentioning

confidence: 73%

Seeded Growth of Cu_2–xSe Nanocrystals and Their Size-Dependent Phototherapeutic Effect

Ding

Kuang

et al. 2018

ACS Appl. Nano Mater.

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Doped semiconductors supporting localized surface plasmon resonances, such as nonstoichiometric copper chalcogenides Cu 2−x Se, have been intensively researched for their potential applications in photoacoustic imaging and photothermal therapy. For these self-doped nanoparticles, their physicochemical attributes such as size and surface chemistry will not only affect their cellular uptake and biodistribution but also influence their own optical properties. Thus, optimization of the physicochemical properties is crucial for their nanobio-applications. Through a seeded growth approach, aqueous phase synthesis of monodisperse Cu 2−x Se with various sizes has been developed for the first time. Taking three different sized Cu 2−x Se NPs (35, 65, and 105 nm in diameter) as examples, their size-dependent optical cross-section, photothermal property, and cellular cytotoxicity have been investigated, and the 65 nm one displays the largest optical cross-section at 21.57 L g −1 cm −1 and best photothermal property per unit mass. In addition, Cu 2−x Se exhibits a size-dependent reactive oxygen species generation effect that is inversely proportional to their diameters. Finally, on the basis of optical property and cytotoxicity optimizations, the photothermal cancer cell ablation ability and potential use of Cu 2−x Se NPs as photoacoustic contrast enhancing agent has been demonstrated in vivo.

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Section: ■ Results and Discussionmentioning

confidence: 73%

Seeded Growth of Cu_2–xSe Nanocrystals and Their Size-Dependent Phototherapeutic Effect

Ding

Kuang

et al. 2018

ACS Appl. Nano Mater.

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“…Nanocarrier systems have many advantages, such as a large surface area, multiple functionalization, and small sizes [2]. Because of these superior features, AuNPs have been widely preferred in biomedical research recently, with applications that include detection [3], biosensors [4], bio-imaging [5], photothermal therapy [6], drug delivery [7], and DNA or RNA delivery [8,9]. Also, to the beneficial effects of nanomaterials, there is a critical need to investigate the potentially toxic effects of AuNPs in biological environments.…”

Section: Introductionmentioning

confidence: 99%

Histological changes in mice tissues induced by gold nanoparticles with different surface coatings and sizes

Özçiçek¹,

Aytürk²,

Ayşit³

2022

j-ebr

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Gold nanoparticles (AuNPs) have many biomedical applications due to their unique properties (e.g., chemical stability, optical properties, biocompatibility, easy synthesizability, and multiple functionalizations). This study aimed to synthesize two highly monodispersed and stable AuNPs of different sizes (AuNP20 and AuNP50), modified with polyethyleneimine (PEI) and polyethylene glycol (PEG), and systematically investigate their toxicological effects on histological changes in the organs of BALB/c mice. Methods: AuNPs (AuNP20 and AuNP50) were synthesized, and their surfaces were coated with PEI and PEG. All necessary characterizations were performed. After the application of two different doses of intravenous injections (IV) of the AuNPs (0.5 and 5 mg Au/kg), their toxicological effects and histological changes in the various mice organs (e.g., liver, spleen, kidney, brain) were evaluated with multiple parameters 48 h post injection. Fourteen days after a single high dose (5 mg Au/kg) IV injection of AuNPs, transmission electron microscopy (TEM) analysis was performed to reveal their ultrastructural effects in the liver of the mice. Results: Stable and highly monodispersed AuNPs were synthesized successfully. Since the liver is the most critical organ in nanotoxicological evaluations, changes in the parameters of AuNPs were shown to have remarkable effects. Although there were no differences in the impact caused between the two AuNPs sizes, the microstructure of the liver tissue treated with AuNP nanoparticles with PEI or PEG coatings was similar to that observed in the control group. Microstructural histological changes in the other organs (e.g., brain, kidney, and spleen) were relatively less than those found in the liver. The PEI and PEG surface coatings generally increased the biocompatibility of the AuNPs. According to the TEM analysis data, apparent cellular changes were observed after a long exposure period in the AuNP groups without an additional surface coating. Although slight cellular alterations were observed in the AuNP groups coated with PEG and PEI, the morphology of the hepatocyte cells was generally healthy. Conclusion:The surface coating of the AuNPs was a more decisive parameter than the size of the nanoparticles in terms of in vivo histological toxicity. The stability, biocompatibility, and surface coating of the AuNPs were critical parameters for potential nanoteranostic applications.

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“…Size effect, i. e. dependency of the physicochemical properties on the atomic sizes/morphology, is one of the most intriguing characteristics of nanomaterials [1–4] . In the past decades, a variety of external stimuli (such as heating and redox conditions) have been utilized to regulate size evolution of metal nanomaterials [5–7] .…”

Section: Introductionmentioning

confidence: 99%

Aggregative Growth of Oligopeptide‐Protected Gold Nanoclusters into Plasmonic Particles

Zheng

et al. 2022

ChemNanoMat

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The stimuli response of nanomaterials represents a highly appealing characteristic, whereas the practical applications (in catalysis, biosensing etc.) are largely restricted by the limited understanding on the recognition mechanism. Herein, we report a pH‐regulated size evolution from atomically precise Au nanoclusters (NCs) to plasmonic nanoparticles (NPs). The spectral monitoring demonstrates a three‐stage aggregative growth pathway. First, the non‐covalent interactions among the exterior oligopeptide ligands are gradually enhanced with the increased alkalinity, and then the Au−S bonding is partially disrupted, with the exposed Au atoms aggregating to form relatively larger, polydisperse clusters under weak alkaline conditions. Finally, size‐redistribution occurs slowly under strong alkaline conditions to form the plasmonic particles. The controllable transition sheds light on the transition characteristics from molecular state to metallic state of Au nanomaterials.

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Effects of gold core size on regulating the performance of doxorubicin-conjugated gold nanoparticles

Cited by 25 publications

References 38 publications

Seeded Growth of Cu_2–xSe Nanocrystals and Their Size-Dependent Phototherapeutic Effect

Seeded Growth of Cu_2–xSe Nanocrystals and Their Size-Dependent Phototherapeutic Effect

Histological changes in mice tissues induced by gold nanoparticles with different surface coatings and sizes

Aggregative Growth of Oligopeptide‐Protected Gold Nanoclusters into Plasmonic Particles

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Effects of gold core size on regulating the performance of doxorubicin-conjugated gold nanoparticles

Cited by 25 publications

References 38 publications

Seeded Growth of Cu2–xSe Nanocrystals and Their Size-Dependent Phototherapeutic Effect

Seeded Growth of Cu2–xSe Nanocrystals and Their Size-Dependent Phototherapeutic Effect

Histological changes in mice tissues induced by gold nanoparticles with different surface coatings and sizes

Aggregative Growth of Oligopeptide‐Protected Gold Nanoclusters into Plasmonic Particles

Contact Info

Product

Resources

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Seeded Growth of Cu_2–xSe Nanocrystals and Their Size-Dependent Phototherapeutic Effect

Seeded Growth of Cu_2–xSe Nanocrystals and Their Size-Dependent Phototherapeutic Effect