Effects of glutamic acid and taurine on total parenteral nutrition

Terauchi, Takashi; Fujiwara, Toshio; Sunagawa, Masakatu

doi:10.1016/j.jpedsurg.2006.05.021

Cited by 13 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, Akkermansia was resistant to vancomycin and metronidazole, which were used in the experiments here [ 32 ]. In a total parenteral nutrition (TPN) study, intestinal mucosal thickness and villus height improved with taurine [ 35 ]. Taurine increases the number and function of goblet cells to improve the intestinal mucosal barrier during nematode infection [ 36 ], which also occurs when lipopolysaccharide (LPS) induces acute intestinal mucosal inflammation [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis

Qian

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Taurine, an abundant free amino acid, plays multiple roles in the body, including bile acid conjugation, osmoregulation, oxidative stress, and inflammation prevention. Although the relationship between taurine and the gut has been briefly described, the effects of taurine on the reconstitution of intestinal flora homeostasis under conditions of gut dysbiosis and underlying mechanisms remain unclear. This study examined the effects of taurine on the intestinal flora and homeostasis of healthy mice and mice with dysbiosis caused by antibiotic treatment and pathogenic bacterial infections. The results showed that taurine supplementation could significantly regulate intestinal microflora, alter fecal bile acid composition, reverse the decrease in Lactobacillus abundance, boost intestinal immunity in response to antibiotic exposure, resist colonization by Citrobacter rodentium, and enhance the diversity of flora during infection. Our results indicate that taurine has the potential to shape the gut microbiota of mice and positively affect the restoration of intestinal homeostasis. Thus, taurine can be utilized as a targeted regulator to re-establish a normal microenvironment and to treat or prevent gut dysbiosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis

Qian

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Furthermore, increased taurine levels were found in the Arg injection group. Taurine was reported to exert the protective effects on intestinal damage through its various physiological functions such as antioxidant properties [60][61][62], while bile acids conjugated by taurine are detrimental to the intestinal mucosal structure of chickens [63]. Besides resulting from abundant Ruminococcaceae promoting 7αdehydroxylation reaction for generation of secondary bile acids [42], the lower levels of taurine-conjugated bile acids might also be related to the enzyme system catalyzing conjugation in the liver [64].…”

Section: Discussionmentioning

confidence: 99%

Dynamic alterations in early intestinal development, microbiota and metabolome induced by in ovo feeding of L-arginine in a layer chick model

Dai¹,

Wu²,

Zhang³

et al. 2020

J Animal Sci Biotechnol

View full text Add to dashboard Cite

Background: Prenatal nutrition is crucial for embryonic development and neonatal growth, and has the potential to be a main determinant of lifelong health. In the present study, we used a layer chick model to investigate the effects of in ovo feeding (IOF) of L-arginine (Arg) on growth, intestinal development, intestinal microbiota and metabolism. The treatments included the non-injected control, saline-injected control, and saline containing 2, 6, or 10 mg Arg groups. Results: IOF Arg increased early intestinal index and villus height, and enhanced uptake of residual yolk lipid, contributing to subsequent improvement in the early growth performance of chicks. Prenatal Arg supplementation also increased the early microbial α-diversity, the relative abundance of Lactobacillales and Clostridiales, and decreased the relative abundance of Proteobacteria of cecum in chicks. Furthermore, the shift of cecal microbiota composition and the colonization of potential probiotics were accelerated by IOF of Arg. Simultaneously, metabolomics showed that metabolisms of galactose, taurine-conjugated bile acids and lipids were modulated to direct more energy and nutrients towards rapid growth of intestine at the beginning of post-hatch when embryos received IOF of Arg. Conclusions: Prenatal Arg supplementation showed beneficial effects on the early intestinal development, cecal microbiota and host metabolism of layer chicks, contributing to subsequent improvement in the early growth performance. These findings provide new insight into the role of IOF of Arg in the establishment of the gut microbiota of newly-hatched layer chicks, and can expand our fundamental knowledge about prenatal nutrition, early bacterial colonization and intestinal development in neonate.

show abstract

“…The atrophic mucosa would predictably be more susceptible to the translocation of bacteria and/or bacterial products from the intestinal lumen [5]. TPN-induced atrophy has been associated with a significant increase in epithelial cell apoptosis [5,6,30,31]. The mechanism for the increase in TPN-associated epithelial apoptosis is associated with IEL.…”

Section: Discussionmentioning

confidence: 99%

Kampo Medicine “Dai-Kenchu-To” Prevents Bacterial Translocation in Rats

et al. 2008

View full text Add to dashboard Cite

Kampo medicine "Dai-kenchu-to" (DKT) has been used for treatment of ileus. The aim of this study was to evaluate the role of DKT on the bacterial translocation (BT) model in rats. Rats were divided into the following four groups: group 1, receiving only water, and groups 2, 3, and 4, receiving 100, 300, and 1,000 mg/kg/day of DKT. Rats were sacrificed 6 days after the beginning of the fast, and then the mesenteric lymph node was cultured. Inflammatory cytokines, intestinal integrity, and apoptosis were assessed. Incidence of BT in groups 3 (33%) and 4 (16%) was lower than in group 1 (66%). Interferon-gamma expression in groups 2, 3, and 4 was significantly lower than in group 1. Villous height and number of villus in groups 2, 3, and 4 were significantly taller and greater than in group 1. Apoptotic index in groups 2, 3, and 4 was significantly lower than in group 1. This is the first evidence that DKT prevents BT by reducing inflammatory reaction and maintaining intestinal integrity.

show abstract

Effects of glutamic acid and taurine on total parenteral nutrition

Cited by 13 publications

References 33 publications

Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis

Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis

Dynamic alterations in early intestinal development, microbiota and metabolome induced by in ovo feeding of L-arginine in a layer chick model

Kampo Medicine “Dai-Kenchu-To” Prevents Bacterial Translocation in Rats

Contact Info

Product

Resources

About