Effects of Gastric Bypass Surgery on Female Reproductive Function

Legro, Richard S.; Dodson, William C.; Gnatuk, Carol L.; Estes, Stephanie J.; Kunselman, Allen R.; Meadows, Juliana W.; Kesner, James S.; Krieg, Edward F.; Rogers, Ann M.; Haluck, Randy S.; Cooney, Robert N.

doi:10.1210/jc.2012-2205

Cited by 99 publications

(72 citation statements)

References 42 publications

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“…It has been reported that DHEA-S levels decreased significantly at the end of the 2 nd year when compared to initial levels and no significant differences were observerd at the end of the 1st year and between the first and second years (8). Legro et al (2012) in their study, reported that SHBG levels increased during the first month (p <0.001), testosterone levels decreased in the 3rd month (p = 0.002), estrogen levels decreased in 6th month (p = 0.03), and progesterone levels did not change significantly (17).…”

Section: Results Regarding Hormone Levelsmentioning

confidence: 95%

Bariatrik Cerrahi Cinselliği Etkiler Mi? Sistematik Derleme

Aygin

Acar

2017

Journal of Contemporary Medicine

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Obesity affects sexual health negatively due to several reasons such as impaired body image, psychological disorders and hormonal changes. Bariatric surgery is frequently used in the treatment of obesity. Besides positive effects such as an increase in physical activity due to weight loss and hormonal changes after surgery, there are some adverse effects of bariatric surgery such as sagging and wrinkling of skin due to rapid weight loss. The purpose of this study is to determine the effects of bariatric surgery on sexual function. The literature between 2004 and 2015 was reviewed by searching Scopus, Science Direct, PubMed, Ebsco, Coochrane, Medline Complete, Ovid, Springer Link, Google Scholar, Taylor & Francis, PsychInfo databases, national thesis center and Ulakbim databases; ten studies appropriate to the criteria were included in the study. A total of 524 patients (152 males) underwent bariatric surgery were included in study. Sexual function has been found to improve in all the studies. Also weight loss has been shown to have positive effects on reproductive hormones in both sexes. Bariatric surgery has positive effects on weight-loss and consequently on sexual function and reproductive hormones.

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Section: Results Regarding Hormone Levelsmentioning

confidence: 95%

Bariatrik Cerrahi Cinselliği Etkiler Mi? Sistematik Derleme

Aygin

Acar

2017

Journal of Contemporary Medicine

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“…From a metabolic point of view, the improved insulin sensitivity was proved by the decrease in fasting insulin levels. With regard to the reproductive system, the restoration of regular menstrual cycles and ovulation were noticed [60].…”

Section: Surgical Treatment Of Obesity-bariatric Surgerymentioning

confidence: 99%

Lifestyle Changes and Weight Loss: Effects in PCOS

Ionescu¹,

Popescu²,

Banacu³

et al. 2018

Debatable Topics in PCOS Patients

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Even though controversies surrounding the polycystic ovary syndrome are not yet close to be solved, its clinical manifestations are well known-insulin resistance and obesity, hirsutism, irregular and anovulatory menstrual cycles. The treatment of polycystic ovarian syndrome (PCOS) is mainly symptomatic as its etiology is not yet clear. Lifestyle changes are the primary therapy in overweight and obese women with PCOS. According to majority of the studies, lifestyle changes are the most efective form of treatment not only for weight loss but also for the improvement of insulin sensitivity, decreasing incidence of metabolic syndrome and type 2 diabetes. Studies also show that weight loss has fertility beneits by restoring ovulatory cycles. Although initial studies researching pharmacologic treatment were showing excellent results concerning the weight loss, maintenance of weight loss and reduction of cardiovascular risks, some of these drugs were in the end, has proven to actually increase the risk for cardiovascular events and were removed from the market. Bariatric surgery has been demonstrated to improve or even cure type 2 diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea. More so, there are studies that reported complete resolution of all features of PCOS, even hirsutism, hyperandrogenism, anovulation, and menstrual irregularity.

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“…S. Palomba, оценивавший эффек-тивность прегестационного использования Мет-формина у женщин с синдромом поликистозных яичников и высоким риском осложненного тече-ния беременности, не выявил терапевтического эффекта препарата на основании результатов анализа 17 рандомизированных исследований, проведенных у такой категории пациенток [21]. Принимая во внимание подобные результаты, неудивительно, что медицинская общественность и комитеты, ответственные за разработку нацио-нальных рекомендаций в таких странах, как США [22] и Великобритания [23], занимают осторожную позицию в отношении использования Метформи-на при данной патологии.…”

Section: консервативные способы восстановления репродуктивного здоровьяunclassified

“…В 2012 г. R. S. Lergo предпринял попытку доказать, что снижение массы тела вследствие гастрошун-тирования по Ру приводит к улучшению репро-дуктивной функции [22]. Было установлено, что снижение массы тела не сопровождалось каки-ми-либо изменениями в эндокринных менстру-альных параметрах.…”

Section: хирургические методы леченияunclassified