Effects of garlic extract treatment in normal and streptozotocin diabetic rats infected with Candida albicans

Bokaeian, Mohammad; Nakhaee, Alireza; Moodi, Bita; Farhangi, Ali Akbar; Akbarzadeh, Azim

doi:10.1007/s12291-010-0033-y

Cited by 22 publications

(17 citation statements)

References 39 publications

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“…It has been proven over and over that garlic is an effective anti-fungal agent. Its compounds are very active against C. albicans and NACs isolates (Jafari et al, 2007;Bokaeian et al, 2010). In this study, A. vera and Calendula extracts were also found effective.…”

Section: Herbal Sensitivitysupporting

confidence: 62%

Antifungal resistance and herbal sensitivity of oral Candida isolates from HIV-infected patients in a rural community in Western Uttar Pradesh, India

Gautam¹,

Garg²

2014

Afr. J. Microbiol. Res.

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Drug-resistant Candida species in HIV-infected patients are the result of the selective pressure of currently used azoles. In the course of screening for active plant products against drug-resistant Candida species, we paid special attention on the effects of commonly available herbal plants. A total of 123 oral Candida isolates which were previously isolated from 172 HIV-infected patients were included in this study. In vitro antifungal susceptibility to fluconazole (FCZ), itraconazole (ITZ) and amphotericin B (AMB) was evaluated using Clinical and Laboratory Standard Institute (CLSI) guidelines. Antifungal potency of garlic, neem, Aloe, Calendula, Citrus, mint, tea and ginger extracts were tested against drugresistant isolates. Out of 123 isolates, 26.8% were resistant to FCZ, 21.9% to ITZ and 8.1% to AMB. All drug-resistant isolates tested, were completely inhibited by garlic and neem leaves extracts with minimum fungicidal concentration (MFC) of 0.781 and 1.562 mg/ml, respectively. Aloe and Calendula extracts were also found to be effective with MFC of 3.125 mg/ml each. The observed growth inhibition zones and minimum inhibitory concentrations (MICs) showed that the isolates exhibited susceptibility. Our results provided scientific justification for the use of garlic, neem, Aloe and Calendula extracts in health products and herbal remedies against multidrug-resistant candidiasis.

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Section: Herbal Sensitivitysupporting

confidence: 62%

Antifungal resistance and herbal sensitivity of oral Candida isolates from HIV-infected patients in a rural community in Western Uttar Pradesh, India

Gautam¹,

Garg²

2014

Afr. J. Microbiol. Res.

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“…This effect was clarified by a previous study, which showed that an alcoholic extract of garlic ameliorates symptoms of diabetes such as hyperglycemia, polydipsia, polyphagia, and weight loss [17]. Garlic administration of diabetic rats could partially maintain the significant increase in the body weight of the diabetic group by 21.7% after 8 weeks.…”

Section: Discussionmentioning

confidence: 90%

A histological study on the possible protective role of garlic in diabetes-induced structural changes in the renal cortex of adult male albino rats

Khalaf¹

2012

The Egyptian Journal of Histology

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“…This result indicates that allicin affects body weight, blood glucose and insulin level. However, most of the studies showed that garlic can reduce blood glucose levels in diabetic mice, rats and rabbits [31][32][33][34]. It is not clear how garlic and allicin actually work in alleviating hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

Osman

Adnan

Bakar

et al. 2012

pjp

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The research purpose was to experimentally investigate the effect of allicin administration on the levels of main type 1 diabetes (IDDM) autoantibodies which are antiislet cell antibodies (ICA) with an attempt to find a relation between this immunological effect and histological and/or biochemical findings. We have evaluated, with the help of ELISA kits, the levels of ICA and serum insulin in male Sprague-Dawley rats with Streptozotocin-induced IDDM in addition to pancreatic histological findings. The four groups (6 rats each) under study received or not different intraperitoneal doses of allicin for a period of 30 days. Daily intraperitoneal administration of allicin (either at as low dose of 8 mg/kg or high dose of 16 mg/kg) for up to 30 days to type 1 diabetic rats effectively reduces levels of anti-islet cell antibodies and in addition, reduced the level of insulin due to damaged Langerhans islet cell was significantly increased in the serum due to a repairing tissue process in pancreatic tissues. These experimental results suggest that allicin treatment has a therapeutic protective effect against autoimmune reactions occurring in IDDM. The data may provide new strategies for using allicin to be recommended as an excellent candidate in the clinical management, control, and prevention of IDDM.

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Effects of garlic extract treatment in normal and streptozotocin diabetic rats infected with Candida albicans

Cited by 22 publications

References 39 publications

Antifungal resistance and herbal sensitivity of oral Candida isolates from HIV-infected patients in a rural community in Western Uttar Pradesh, India

Antifungal resistance and herbal sensitivity of oral Candida isolates from HIV-infected patients in a rural community in Western Uttar Pradesh, India

A histological study on the possible protective role of garlic in diabetes-induced structural changes in the renal cortex of adult male albino rats

Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

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