Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

Osman, Muhamed T.; Adnan, Azlan; Bakar, Nor Salmah; Alashkham, Fatma Ali

doi:10.5114/pjp.2012.32772

Cited by 27 publications

(16 citation statements)

References 28 publications

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“…Additionally, the diabetic group showed an increase in diuresis, creatinine clearance, proteinuria, glycosuria and urinary excretion of NAG, which are considered as hallmarks of renal dysfunction in diabetes. These results are in good agreement with other studies, which reported proteinuria or albuminuria in this experimental model of diabetes [ 3 , 11 , 12 , 15 ]. It has been demonstrated that one month of allicin treatment prevented the loss of body weight in diabetic animals.…”

Section: Discussionsupporting

confidence: 93%

“…Diallyl thiosulfinate (allicin) is a major component formed when garlic ( Allium sativum ) is crushed or ground [ 8 ]. Allicin is considered as a panacea as it has a broad spectrum of physiological activities such as antihypertensives [ 9 , 10 ], antioxidants [ 9 ], antidiabetics [ 11 ], cardioprotectives [ 10 ], nephroprotectives [ 11 ], and immunomodulators [ 12 , 13 ]. As far as nephroprotective mechanisms of allicin in experimental DN are concerned, recent studies have shown that this garlic derivative partially reverses the increased expression of transforming growth factor β (TGF-β) and the activation (i.e., phosphorylation) of its downstream target extracellular signal-regulated kinase ½ (ERK1/2) that drive renal epithelial-mesenchymal transition and fibrosis [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory Effects of the Nutraceutical Garlic Derivative Allicin in the Progression of Diabetic Nephropathy

Buendía

González

Reyes

et al. 2018

IJMS

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Diabetic nephropathy (DN) is presently the primary cause of chronic kidney disease and end-stage renal disease (ESRD). It has been suggested that inflammation and oxidative stress, in addition to or in concert with the metabolic changes, plays an important role in the maintenance and progression of the disease. Therefore, attenuating or blocking these mechanisms may be a therapeutic target to delay the progression of the disease. Diallyl thiosulfinate (allicin), a compound derived from garlic, inhibits free radical formation, increases glutathione synthesis and decreases the levels of proinflammatory molecules in vitro. This research aimed to assess the effect of allicin on oxidative stress and inflammation-induced diabetes. Animals were divided into control and diabetes (streptozotocin 50 mg/kg i.p.), and maintained for 30 days. After 30 days, the group of diabetic animals was subdivided into diabetes and allicin-treated diabetes (16 mg/kg/day oral gavage). The three experimental groups were maintained for another month. We analyzed the status of renal function, oxidative stress and proinflammatory cytokines. The untreated diabetic group showed hyperglycemia and increased diuresis, creatinine clearance, proteinuria, glycosuria and urinary excretion of N-acetyl-β-d-glucosaminidase (NAG), as well as increased oxidative stress and the expression of interleukin 1β (IL-1β), IL-6, nuclear factor kappa beta (NFκβ) and transforming growth factor-β1 (TGF-β1) in plasma and kidney. In contrast, the inhibitor of NFκβ (Iκβ) is decreased in the cortex. It has been demonstrated that the allicin treatment decreases hyperglycemia, polyuria, and NAG excretion. The oxidative stress and proinflammatory cytokines were also reduced by the allicin treatment. In conclusion, allicin delays the progression of diabetic nephropathy through antioxidant and anti-inflammatory mechanisms.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of the Nutraceutical Garlic Derivative Allicin in the Progression of Diabetic Nephropathy

Buendía

González

Reyes

et al. 2018

IJMS

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“…Albajali et al (2011) reported that the aqueous extract of A. sativum increased the diameter of pancreatic islets in STZ-induced diabetic rats. In another study, intraperitoneal injection of A. sativum oil decreased beta cell degeneration and level of anti-islet antibodies in the animals with T1D (Osman et al, 2012). Alashkham et al (2013) also showed regenerative action of this oil in the pancreatic islets of diabetic rats.…”

Section: Allium Sativummentioning

confidence: 94%

“…Allicin is the major active component of A. sativum and a precursor of many secondary compounds formed in crushed garlic preparations or aged garlic. This compound has been proposed to be responsible for the health promotion benefits of A. sativum and protective actions in pancreatic islets (Osman et al, 2012).…”

Section: Allium Sativummentioning

confidence: 99%

Pancreatic beta cell protection/regeneration with phytotherapy

Hosseini

Shafiee-Nick

Ghorbani

2015

Braz. J. Pharm. Sci.

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Although currently available drugs are useful in controlling early onset complications of diabetes, serious late onset complications appear in a large number of patients. Considering the physiopathology of diabetes, preventing beta cell degeneration and stimulating the endogenous regeneration of islets will be essential approaches for the treatment of insulin-dependent diabetes mellitus. The current review focused on phytochemicals, the antidiabetic effect of which has been proved by pancreatic beta cell protection/regeneration. Among the hundreds of plants that have been investigated for diabetes, a small fraction has shown the regenerative property and was described in this paper. Processes of pancreatic beta cell degeneration and regeneration were described. Also, the proposed mechanisms for the protective/ regenerative effects of such phytochemicals and their potential side effects were discussed. Embora medicamentos disponíveis atualmente sejam úteis no controle de complicações da Diabetes, complicações aparecem em grande número de pacientes. Considerando-se a fisiopatologia do Diabetes, a prevenção da degeneração de células beta e o estímulo da regeneração endógena de ilhotas será abordagem essencial para o tratamento de diabetes mellitus insulino-dependente. A presente revisão aborda compostos fitoquímicos, cujo efeito é provado na proteção/regeneração de células beta de pâncreas. Entre centenas de plantas que têm sido investigadas para o diabetes, pequena fração tem mostrado propriedade regenerativa, que será descrita neste trabalho. Os processos de degeneração e de regeneração das células beta do pâncrease são descritos. Além disso, mecanismos propostos para efeitos de proteção e regeneração desses compostos fitoquímicos e seus possíveis efeitos colaterais também serão discutidos neste trabalho.Unitermos: Diabetes mellitus/tratamento. Diabetes mellitus/fitoterapia. Fitoterapia/Diabetes mellitus. Ilhotas/regeneração endógena. Células beta/proteção. Células beta/regeneração. Pâncreas. Plantas medicinais/propriedades regenerativas.

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“…In addition, allicin may stimulate the immune system to release more active factors, which could inhibit the growth of tumor cells through enhancement of its anticancer effects (3,7). As compared with traditional chemotherapy drugs, in the clinical treatment of tumors allicin not only has no toxic effects on the body, but may also stimulate the body to release various cytokines and enhance immune resistance (5,9).…”

Section: Introductionmentioning

confidence: 99%

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

Zhang¹,

Zhu

Duan³

et al. 2014

Molecular Medicine Reports

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Gastric cancer is one of the most common forms of malignant tumor, and the development of anti‑gastric cancer drugs with minimal toxicity is of clinical importance. Allicin is extracted from Allium sativum (garlic). Recent research, including clinical experiments, has shown that garlic has anticancer and tumor suppressive effects. The present study aimed to investigate the effects of allicin on the MGC‑803 human gastric carcinoma cell line, and to further explore the possible mechanisms of its tumor suppressor effects. The effects of allicin on the MGC‑803 cells were initially examined using an 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay. Hoechst staining was also used, in order to demonstrate the impact of allicin on MGC‑803 cell apoptosis. In addition, western blot analysis was performed to determine the abnormal expression levels of apoptosis‑associated proteins, following the treatment of MGC‑803 cells with allicin. Western blotting was also used to investigate the specific mechanisms underlying allicin‑induced apoptosis of MGC‑803 cells. The rate of MGC‑803 apoptosis was significantly increased, when the concentration and treatment time of allicin were increased. Hoechst staining detected an enhanced rate of apoptosis, and enhanced expression levels of cleaved caspase 3 were determined by western blotting. Notably, the protein expression levels of p38 were increased when the MGC‑803 cells were treated with allicin. The results of the present study suggest that allicin may inhibit the proliferation and induce the apoptosis of MGC‑803 human gastric carcinoma cells, and this may partially be achieved through the enhanced expression of p38 and cleaved caspase 3.

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Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

Cited by 27 publications

References 28 publications

Immunomodulatory Effects of the Nutraceutical Garlic Derivative Allicin in the Progression of Diabetic Nephropathy

Immunomodulatory Effects of the Nutraceutical Garlic Derivative Allicin in the Progression of Diabetic Nephropathy

Pancreatic beta cell protection/regeneration with phytotherapy

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

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