Effects of Ganoderma lucidum Extract on Diabetic Rats

Abstract

Diabetes mellitus (DM) is a metabolic syndrome which occurs when insulin is insufficiently produced or insulin cannot well serve its function. Diabetes is marked with increase in blood glucose level followed by increase in glycosylated hemoglobin level and decrease in insulin level. This research aims to examining the effect of Ganoderma lucidum extract on the blood glucose, insulin and glycosylated hemoglobin (HbA1c) level of diabetic white rat and determining the most effective dose of extract to be a diabetic agent. This research was experimentally conducted by employing Completely Randomized Design (CRD) with 6 treatments and 4 repetitions. The treatment groups consisted of healthy rats group (K1), rats with diabetes as negative control (K2), diabetic rats with the administration of metformin 45 mg/kg BW as the comparison (K3) and diabetic rats with the administration of G. lucidum extract with dose of 250, 500 and 1000 mg /kg BW (K4, K5 and K6 respectively). Blood glucose level examination was conducted after the alloxan induction with single dose of 125 mg/kg BW by intraperitoneal injection. The results show that mushroom G. lucidum extract administration with dose of 1000 mg/kg BW (K6) is the best dose to be an anti-diabetic agent. The benefit of the research is developing anti-diabetic agent from herbal resources.

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

“…Earlier studies show that mushrooms are rich in ß-D-glucans, ß-glucan, a type of dietary fiber that shows promising health benefits against T2DM [80]. Mushroom extracts from Pleurotus species [56], Boletu [58], Grifola frondosa [81], Agaricus bisporus [38], Hericium erinaceus [63], and Ganoderma lucidum [82] regulate the synthesis of glycogen and lowers blood glucose levels by regulating gene expression of glycogen synthase kinase (GSK-3 ß), glycogen synthase (GS) and glucose transporter 4 (GLUT4) in liver and muscle. Therefore GSK-3 ß could be identified as an insulin-mediated GSregulated negative regulator [83].…”

The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk

“…A hypoglycaemic effect was also observed following administration of an alcoholic extract of G. lucidum (250, 500, and 1000 mg/kg) given for 14 days in alloxan-induced diabetic rats (Ratnaningtyas et al. 2018 ). Another recent study in streptozotocin-induced diabetic rats showed that a hydroethanolic extract of G. lucidum containing β-glucan, proteins, and phenols, reduced plasma glucose and lipid levels through preservation of pancreatic islets (Bach et al.…”

Activity of mushrooms against diabetic and inflammation: A review

“…Mycelial extract of Pleurotus ostreatus was noticed to reduce the serum glucose level in streptozotocin-induced diabetes mellitus in rats [34]. Ganoderma lucidum ethanol extract of powdered fruiting bodies reduce serum glucose in white rats [35]. Also, water and 80% ethanol extracts of fruiting bodies of Ganoderma lucidum decreased glucose level in serum of streptozotocin-induced diabetic rats [36].…”