Activity of mushrooms against diabetic and inflammation: A review

Al-Faqeeh, Lena Ahmed Saleh; Naser, Rafiuddin; Kagne,; Khan, Subur W.

doi:10.30574/gscbps.2021.14.2.0035

Cited by 5 publications

(1 citation statement)

References 64 publications

(55 reference statements)

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“…Several reviews on mushroom polysaccharides have been previously published ( Lo and Wasser, 2011 ; De Silva et al, 2012 ; Ganesan and Xu, 2019 ; Jiang et al, 2020 ; Khursheed et al, 2020 ; Lindequist and Haertel, 2020 ; Al-Faqeeh et al, 2021 ). However, these studies do not sufficiently discuss oxidative stress, which results mainly through the action of RONS triggered by hyperglycemia, and which is known to contribute to the development and progression of diabetes and other complications.…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

Arunachalam

Sasidharan²,

Yang

2022

Front. Pharmacol.

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Diabetes mellitus is a prevalent metabolic and endocrine illness affecting people all over the world and is of serious health and financial concern. Antidiabetic medicine delivered through pharmacotherapy, including synthetic antidiabetic drugs, are known to have several negative effects. Fortunately, several natural polysaccharides have antidiabetic properties, and the use of these polysaccharides as adjuncts to conventional therapy is becoming more common, particularly in underdeveloped nations. Oxidative stress has a critical role in the development of diabetes mellitus (DM). The review of current literature presented here focusses, therefore, on the antioxidant properties of mushroom polysaccharides used in the management of diabetic complications, and discusses whether these antioxidant properties contribute to the deactivation of the oxidative stress-related signalling pathways, and to the amelioration of β-cell dysfunction and insulin resistance. In this study, we conducted a systematic review of the relevant information concerning the antioxidant and antidiabetic effects of mushrooms from electronic databases, such as PubMed, Scopus or Google Scholar, for the period 1994 to 2021. In total, 104 different polysaccharides from mushrooms have been found to have antidiabetic effects. Most of the literature on mushroom polysaccharides has demonstrated the beneficial effects of these polysaccharides on reactive oxygen and nitrogen species (RONS) levels. This review discuss the effects of these polysaccharides on hyperglycemia and other alternative antioxidant therapies for diabetic complications through their applications and limits, in order to gain a better understanding of how they can be used to treat DM. Preclinical and phytochemical investigations have found that most of the active polysaccharides extracted from mushrooms have antioxidant activity, reducing oxidative stress and preventing the development of DM. Further research is necessary to confirm whether mushroom polysaccharides can effectively alleviate hyperglycemia, and the mechanisms by which they do this, and to investigate whether these polysaccharides might be utilized as a complementary therapy for the prevention and management of DM in the future.

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Section: Introductionmentioning

confidence: 99%

The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

Arunachalam

Sasidharan²,

Yang

2022

Front. Pharmacol.

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Characterization of Secondary Metabolites Identified in Lentinula edodes and Determination of Their Biological Activities by in‐silico Antioxidant Screening

Amin,

Afzal,

Riaz

2023

ChemistrySelect

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Mushrooms, like other fungi, are unique in the living world They have been assigned to the kingdom of Myceteae. Lentinula edodes(shiitake), is second‐largest and most often consumed edible mushroom in the world. Shiitake mushroom possess large capability to be used as food as it contains carbohydrates, proteins, vitamins, minerals, fibers, fatty acids, amino acids, etc. In current study powdered form mushroom used to form semisolid extract in selected fractions (Butanol, ethyl acetate, hexane, chloroform and aqueous). The aim of the current study was to explore phytoconstituents which have biological activities in selected fractions (n. hexane chloroform, and ethyl acetate) of methanolic extract of Lentinula edodes.GC‐MS, and HPLC analysis presented the secondary metabolites in all the selected fractions under taken. Chloroform fraction had the highest total phenolic, and total flavonoid which exhibited the maximum in vitro antioxidant ABTS potential (74.78±0.83) potential at 350 μg/mL while ethyl acetate has moderate and n‐hexane shows least concentration. Hemolysis essay showed less than 10 % lysis of RBC, s which indicates that fractions under study are active, and safe to use as herbal medicine. Biomolecules detected through HPLC and GC‐MS in fractions under study showed significant inhibition in paw inflammation (1.18±0.06) and yeast induced pyrexia (36.8±0.68) in dose dependent manner. Furthermore, In‐silico study showed that 4H‐Furo[3,2‐b] pyrrole‐5‐carboxylic acid have a strong interaction to NADPH oxidase, Myeloperoxidase as compared to standard Melatonin which shows best antioxidant compound which was confirmed in chloroform fraction.The outcomes of this research indicated that L. edodes significantly reduced inflammation and have ability to scavenge free radicals, prevent protein denaturation, also indicate the possible use in food and nutraceutical applications as an antioxidant, antipyretic, anti‐inflammatory, and antidiabetic agent.

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A review on Blewit mushrooms ( Lepista sp.) transition from farm to pharm

Nandi

Acharya

2022

Food Processing Preservation

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Mushrooms are an emerging natural resource to meet the current demands of functional food and therapeutics. Modern pharmacological as well as clinical trials of new‐age drugs have presented the nutritional and medicinal attributes of mushrooms in light. One such resource is the genus Lepista of the family Tricholomataceae, which is yet to be explored wholly. In recent years, the abandoned taxon Lepista has been in focus for the reason of its palatability, farming procedure, and curative importance. The key message of the review is to update the present status of the genus Lepista with reference to its significance as functional food, a new source of bioactive components, and therapeutic value, which will put forward beneficial guidance and new approaches for its advancement as a potent mycomedicine. Practical applications Application of mushrooms as food and medicine was conducted from the nutritional contents point of view and as medicinal value. In this field, the species of Lepista is globally admired but they are still largely unexplored. The present findings illustrate the promising nutritional and medicinal benefits of Lepista nuda and Lepista sordida. Additionally, the cultivation process of this species provides the people with additional vegetables of high quality and enriches the diet, which can be of direct benefit to human health and fitness.

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Activity of mushrooms against diabetic and inflammation: A review

Cited by 5 publications

References 64 publications

The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

Characterization of Secondary Metabolites Identified in Lentinula edodes and Determination of Their Biological Activities by in‐silico Antioxidant Screening

A review on Blewit mushrooms ( Lepista sp.) transition from farm to pharm

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