Effects of Functionally Graded Hydroxyapatite for Large Mandibular Defects in Adult Rabbits

Yoshimoto, Ryota; Murata, Masaru; Akazawa, Toshiyuki; Arisue, Makoto

doi:10.2485/jhtb.19.33

Cited by 4 publications

(4 citation statements)

References 20 publications

(13 reference statements)

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“…In this way, HAP coatings improved the biological fixation, biocompatibility, and bioactivity of implants [85]. In addition, deposition methods such as spraying, sputtering, pulsed laser deposition, and sol-gel techniques have been attempted, and several reports have been published whereby bone formation was promoted by increasing cellular response [86–88]. Furthermore, studies on bone regenerative applications have been carried out by mixing HAP with soft materials such as polymers to complement the drawbacks.…”

Section: Types Of Calcium Phosphatesmentioning

confidence: 99%

Bioactive calcium phosphate materials and applications in bone regeneration

et al. 2019

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BackgroundBone regeneration involves various complex biological processes. Many experiments have been performed using biomaterials in vivo and in vitro to promote and understand bone regeneration. Among the many biomaterials, calcium phosphates which exist in the natural bone have been conducted a number of studies because of its bone regenerative property. It can be directly contributed to bone regeneration process or assist in the use of other biomaterials. Therefore, it is widely used in many applications and has been continuously studied.MainbodyCalcium phosphate has been widely used in bone regeneration applications because it shows osteoconductive and in some cases osteoinductive features. The release of calcium and phosphorus ions regulates the activation of osteoblasts and osteoclasts to facilitate bone regeneration. The control of surface properties and porosity of calcium phosphate affects cell/protein adhesion and growth and regulates bone mineral formation. Properties affecting bioactivity vary depending on the types of calcium phosphates such as HAP, TCP and can be utilized in various applications because of differences in ion release, solubility, stability, and mechanical strength. In order to make use of these properties, different calcium phosphates have been used together or mixed with other materials to complement their disadvantages and to highlight their advantages. Calcium phosphate has been utilized to improve bone regeneration in ways such as increasing osteoconductivity for bone ingrowth, enhancing osteoinductivity for bone mineralization with ion release control, and encapsulating drugs or growth factors.ConclusionCalcium phosphate has been used for bone regeneration in various forms such as coating, cement and scaffold based on its unique bioactive properties and bone regeneration effectiveness. Additionally, several studies have been actively carried out to improve the efficacy of calcium phosphate in combination with various healing agents. By summarizing the properties of calcium phosphate and its research direction, we hope that calcium phosphate can contribute to the clinical treatment approach for bone defect and disease.

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Section: Types Of Calcium Phosphatesmentioning

confidence: 99%

Bioactive calcium phosphate materials and applications in bone regeneration

et al. 2019

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“…55 Studies have suggested that both amorphous and crystalline phases in the coatings are desirable to promote a more stable interface with the biological environment. 56,57 Thinner HA layers, in the nanometer range, revealed increased cellular response than thicker HA layers. [58][59][60] Biomimetic nano-apatite coatings of porous titanium scaffolds resulted in an enhanced human osteoblast culture as well as greater bone formation in a canine bone in a growth chamber.…”

Section: Chemical and Physical Properties Of Hamentioning

confidence: 99%

Hydroxyapatite–-Past, Present, and Future in Bone Regeneration

Kattimani

Kondaka

Lingamaneni

2016

Bone�Tissue�Regen�Insights

251

196

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Hydroxyapatite (HA) is an essential element required for bone regeneration. Different forms of HA have been used for a long time. The essence of bone regeneration always revolves around the healthy underlying bone or it may be the surroundings that give enough strength. HA is well known for bone regeneration through conduction or by acting as a scaffold for filling of defects from ancient times, but emerging trends of osteoinductive property of HA are much promising for new bone regeneration. Emerging technology has made the dreams of clinicians to realize the use of HA in different forms for various regenerative purposes both in vivo and in vitro. The nanostructured calcium apatite plays an important role in the construction of calcified tissues. The nanostructured material has the ability to attach biological molecules such as proteins, which can be used as functional materials in many aspects, and the capability of synthesizing controlled structures of apatite to simulate the basic structure of bone and other calcified tissues. The process of regeneration requires a biomimetic and biocompatible nanostructured novel material. The nanostructured bioceramic particles are of interest in synthetic bone grafts and bone cements both injectable and controlled setting, so that such composites will reinforce the strength of bioceramics. Extensive research is being carried out for bone regeneration using nanotechnology. Artificial bone formation is not far from now. Nanotechnology has made many dreams come true. This paper gives comprehensive insights into the history and evolution with changing trends in the use of HA for various regenerative purposes.

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“…In the case of notch type defect models in the rabbit model, multiple studies have evaluated defects of various sizes at different locations in the mandible with little consistency, leading to great difficulty in comparing results across these studies24252627282930313235394041. In Table 3, these studies are compared in terms of the size and location of the defect, age of the animal, type of fixation if any and methods of evaluation used.…”

Section: Discussionmentioning

confidence: 99%

Are critical size bone notch defects possible in the rabbit mandible?

Carlisle¹,

Guda

Silliman³

et al. 2019

J Korean Assoc Oral Maxillofac Surg

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Objectives Small animal maxillofacial models, such as non-segmental critical size defects (CSDs) in the rabbit mandible, need to be standardized for use as preclinical models of bone regeneration to mimic clinical conditions such as maxillofacial trauma. The objective of this study is the establishment of a mechanically competent CSD model in the rabbit mandible to allow standardized evaluation of bone regeneration therapies. Materials and Methods Three sizes of bony defect were generated in the mandibular body of rabbit hemi-mandibles: 12 mm×5 mm, 12 mm×8 mm, and 15 mm×10 mm. The hemi-mandibles were tested to failure in 3-point flexure. The 12 mm×5 mm defect was then chosen for the defect size created in the mandibles of 26 rabbits with or without cautery of the defect margins and bone regeneration was assessed after 6 and 12 weeks. Regenerated bone density and volume were evaluated using radiography, micro-computed tomography, and histology. Results Flexural strength of the 12 mm×5 mm defect was similar to its contralateral; whereas the 12 mm×8 mm and 15 mm×10 mm groups carried significantly less load than their respective contralaterals ( P <0.05). This demonstrated that the 12 mm×5 mm defect did not significantly compromise mandibular mechanical integrity. Significantly less ( P <0.05) bone was regenerated at 6 weeks in cauterized defect margins compared to controls without cautery. After 12 weeks, the bone volume of the group with cautery increased to that of the control without cautery after 6 weeks. Conclusion An empty defect size of 12 mm×5 mm in the rabbit mandibular model maintains sufficient mechanical stability to not require additional stabilization. However, this defect size allows for bone regeneration across the defect. Cautery of the defect only delays regeneration by 6 weeks suggesting that the performance of bone graft materials in mandibular defects of this size should be considered with caution.

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Effects of Functionally Graded Hydroxyapatite for Large Mandibular Defects in Adult Rabbits

Cited by 4 publications

References 20 publications

Bioactive calcium phosphate materials and applications in bone regeneration

Bioactive calcium phosphate materials and applications in bone regeneration

Hydroxyapatite–-Past, Present, and Future in Bone Regeneration

Are critical size bone notch defects possible in the rabbit mandible?

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