Effects of Four Preparations of 0.05% Chlorhexidine Diacetate on Wound Healing in Dogs

Abstract

Four chlorhexidine diacetate (CHD) antiseptic wound lavage preparations were evaluated in vivo to determine their effects on second intention wound healing in the dog in vitro to determine their relative antibacterial activity against Staphylococcus intermedius. Chlorhexidine was diluted to 0.05% in sterile water, 0.9% sodium chloride, lactated Ringers solution (LRS), and LRS that was allowed to form a precipitate with CHD. Control solutions included sterile water and LRS. There were no significant differences in wound contraction or epithelialization. All 0.05% CHD preparations provided 100% bacterial kill.

Comparison of polyhexanide, cold atmospheric plasma and saline in the treatment of canine bite wounds

“…The use of chlorhexidine in small animal surgery dates back to the works of Lozier et al . () and Sanchez et al . ().…”

“…While rising MDR rates have led to investigation of wound antiseptics in human medicine (Kramer et al 2004, Assadian 2007, Daeschlein 2013, research regarding wound antisepsis in veterinary patients is sparse. The use of chlorhexidine in small animal surgery dates back to the works of Lozier et al (1992) and Sanchez et al (1988). This recommendation contrasts with the current recommendations in human medicine (Kramer et al 2004, Assadian 2007, Daeschlein 2013.…”

Biology and Diseases of Dogs

“…Bleeding should be controlled with direct pressure; tourniquets are discouraged because of the complications that may arise with inappropriate placement (Swaim, 1980). Several irrigation solutions have been recommended (Lozier et al, 1992;Waldron and Trevor, 1993;Sanchez et al, 1988), but type may not be as important as the volume and pressure of delivery. Anesthesia or analgesia may be necessary and the choice of agent will depend on the size and location of the wound as well as the preference of the clinician.…”

Silver Nanoparticles as Real Topical Bullets for Wound Healing

“…33 A live yeast cell derivative is a water-soluble extract of yeast reported to stimulate angiogenesis, epithelialization, and collagen formation. 34 It has been connected with improved wound healing in dogs. However, in horses, it prolonged wound healing by delaying wound contraction and resulted in excessive granulation tissue formation.…”